Patents by Inventor Yoshikazu Honda

Yoshikazu Honda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing ectoprotein of hepatitis C virus
    Patent number: 6063904
    Abstract: A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: May 16, 2000
    Assignee: Japan as represented by the Director General of the Agency of National Institute of Health
    Inventors: Tatsuo Miyamura, Izumu Saito, Yoshiharu Matsuura, Yoshikazu Honda, Makoto Seki
  • Method of producing ectoprotein of hepatitis C virus
    Patent number: 5830691
    Abstract: A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: November 3, 1998
    Assignee: Japan as respresented by the Director General of the Agency of National Institute of Health
    Inventors: Tatsuo Miyamura, Izumu Saito, Yoshiharu Matsuura, Yoshikazu Honda, Makoto Seki
  • Method for producing ectoprotein of hepatitis C virus
    Patent number: 5789544
    Abstract: A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 4, 1998
    Assignee: National Institute of Health
    Inventors: Tatsuo Miyamura, Izumu Saito, Yoshiharu Matsuura, Yoshikazu Honda, Makoto Seki
  • Diagnostic reagent for hepatitis C
    Patent number: 5750331
    Abstract: A diagnostic reagent for hepatitis C, which detects an antibody induced by infection of hepatitis C virus, and comprises the second envelope protein or first non-structural protein which is encoded by the gene of hepatitis C virus and has a sugar chain. This invention also provide a method for detecting an anti-hepatitis C virus antibody. The use of the diagnostic reagent for hepatitis C according to the present invention makes highly sensitive diagnosis of hepatitis C possible.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: May 12, 1998
    Assignee: Japan as represented by Director General of Agency of National Institute of Health
    Inventors: Tatsuo Miyamura, Izumu Saito, Shizuko Harada, Yoshikazu Honda
  • Diagnostic reagent for hepatitis c
    Patent number: 5747241
    Abstract: A diagnostic reagent for hepatitis C, which detects an antibody induced by infection of hepatitis C virus, comprising the second envelope protein or first non-structural protein which is encoded by the gene of hepatitis C virus and has a sugar chain. This invention also provides a method for detecting an anti-hepatitis C virus antibody. The use of the diagnostic reagent for hepatitis C according to the present invention makes highly sensitive diagnosis of hepatitis C possible.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 5, 1998
    Assignee: Japan as represented by Director General of Agency of National Institute of Health
    Inventors: Tatsuo Miyamura, Izumu Saito, Shizuko Harada, Yoshikazu Honda