Patents by Inventor Yoshikazu Morishita

Yoshikazu Morishita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Endothelin-antagonizing peptide
    Patent number: 6642355
    Abstract: The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y   (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or  and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: November 4, 2003
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
  • Endothelin-antagonizing peptide
    Publication number: 20030055213
    Abstract: Disclosed in a peptide represented by the following formula (I):
    Type: Application
    Filed: January 2, 2001
    Publication date: March 20, 2003
    Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
  • Strains of streptomyces producing endothelin antagonistic peptides
    Patent number: 6194195
    Abstract: The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: February 27, 2001
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
  • Endothelin-antagonizing peptide
    Patent number: 5639860
    Abstract: Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: June 17, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
  • Electric vacuum cleaner having an electric blower driven in accordance with the conditions of floor surfaces
    Patent number: 5255409
    Abstract: An electric vacuum cleaner comprises a main body having an electric blower and a dust collecting chamber, a triac controlling the electric blower, a floor nozzle coupled to the main body, a pressure sensor sensing the pressure in the vicinity of a suction port of the electric blower, a current sensor sensing the current in a rotary brush driving motor of the floor nozzle, and a microcomputer. The microcomputer performs a fuzzy inference on the outputs of the pressure sensor and the current sensor to determine the duty cycle of the blower control triac on the basis of the result of the inference. By doing this, supply of power to the electric blower in accordance with the condition of a floor surface is realized.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: October 26, 1993
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Masakatsu Fujiwara, Yasuyuki Tsuchida, Yuji Nakanishi, Yoshikazu Morishita
  • HS-142-1 compounds
    Patent number: 5132112
    Abstract: Compounds comprising a linear .beta.1.fwdarw.6 glucan esterified by caproic acid, the number of D-glucose residues being from 7 to 40 and the number of caproic acid residues being from 2 to 30, may be be obtained by fermentation of a microorganism of the genus Aureobasidium. These compounds are designated HS-142-1. Preferred microorganism is Aureobasidium pullulans var. melanigenum KAC-2383 (FERM-BP 2407).The compounds of the present invention exhibit excellent antagonistic activity to ANP and are capable of inhibiting the bonding of ANP to ANP receptors.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: July 21, 1992
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Yoshikazu Morishita, Mitsuru Takahashi, Koji Yamada, Tomoyuki Sano, Isao Kawamoto, Katsuhiko Ando, Hiroshi Sano, Yutaka Saito, Hiroshi Kase, Yuzuru Matsuda