Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).

Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).

Abstract: An effective therapeutic agent for subretinal hyperreflective material or retinal diseases accompanying subretinal hyperreflective material is provided by the present invention. Specifically, a therapeutic agent for subretinal hyperreflective material or a retinal disease accompanying subretinal hyperreflective material, containing an aptamer that binds to FGF2 or a salt thereof is provided.

Abstract: The present invention aims to provide an aptamer for TGF-?1. An aptamer having four sets of consecutive G bases, and a combination of the nucleotide sequences represented by the following formula (I) and the formula (II) which binds to TGF-?1 may be useful as a medicament for preventing and/or treating various diseases involving activation of TGF-?1, or a diagnostic agent, or a labeling agent: UAAX??formula (I): ARACUU??formula (II): wherein X is a bond or GU; and R is A or G.

Abstract: A sheet folding apparatus includes a sheet folding unit disposed to fold a sheet and a conveyance unit disposed to feed the sheet to the sheet folding unit in a feed direction orthogonal to a fold direction of the sheet folding unit while correcting a skew of the sheet. The conveyance unit includes an elongated reference guide, a conveyance mechanism disposed to convey the sheet in the feed direction while exerting a force on the sheet toward the reference guide, an adjustment mechanism disposed to adjust an inclination of the reference guide with respect to the feed direction. The apparatus further includes an input unit through which a user inputs a folding misalignment amount of the sheet folded by the sheet folding unit. The inclination of the reference guide is corrected by the adjustment mechanism based on at least the folding misalignment amount inputted through the input unit.

Abstract: A conveying unit 2including conveyor belts 7, a stopper 3positioning a sheet S at a folding position P on a conveying path 2, a knife-type folding unit 4, an anti-bounce roller unit 16having rollers 25a, 25b, and a motor 22 are provided. The rollers can be moved back and forth. A roller rotational speed monitoring unit 31 and a roller position setting unit 32 operatively connected to the motor are further provided. In setting mode, the rollers are moved from an upstream or a downstream of a tail end of the sheet positioned at the folding position P toward the tail end at a constant speed and stopped when the rotational speed of the rollers changes.

Abstract: The present invention provides a preparation formulation capable of stably maintaining the activity of an aptamer, particularly an aptamer for FGF2, for a long term, thereby providing a pharmaceutical preparation containing an aptamer, particularly an FGF2 aptamer, as an active ingredient.

Abstract: A sheet supplying unit 1 supplies sheets S one by one. A knife-type folding unit 5 folds the sheet. A first sensor 28 detects the sheet entering the folding position. A second sensor 30a, 30b detects the sheet passing through the opening. A timer 31 measures a time interval from end of sheet detection by the second sensor to start of sheet detection by the first sensor. A sheet feed interval change unit 33 calculates a reduction amount of the sheet feed interval using the measured values of the timer and changes the sheet feed interval based on the reduction amount each time a predetermined number of the sheets are folded.

Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).

Abstract: A paper folding machine comprising folding mechanisms (11, 15, 24) arranged at folding positions (A-C) on a transport path (1), respectively, guides (8, 19, 20, 28, 29) positioning a paper sheet (F) relative to the folding positions by engagement with at least one side edge of the paper sheet, stoppers (12, 15, 25) stopping and positioning the paper sheet at the folding positions by bringing a leading edge of the paper sheet into contact with the stoppers, a fold misalignment detection unit (50) detecting a fold misalignment amount of the paper sheet for each folding position, and a controller (42) controlling positions of the guides and stoppers. The controller calculates, for each folding position, an average fold misalignment amount, and adjusts the position of the guide and/or stopper associated with the corresponding folding position so as to correct fold misalignment corresponding to the average fold misalignment amount.

Abstract: A conveying unit 2including conveyor belts 7, a stopper 3positioning a sheet S at a folding position P on a conveying path 2, a knife-type folding unit 4, an anti-bounce roller unit 16having rollers 25a, 25b, and a motor 22 are provided. The rollers can be moved back and forth. A roller rotational speed monitoring unit 31 and a roller position setting unit 32 operatively connected to the motor are further provided. In setting mode, the rollers are moved from an upstream or a downstream of a tail end of the sheet positioned at the folding position P toward the tail end at a constant speed and stopped when the rotational speed of the rollers changes.

Abstract: A sheet supplying unit 1 supplies sheets S one by one. A knife-type folding unit 5 folds the sheet. A first sensor 28 detects the sheet entering the folding position. A second sensor 30a, 30b detects the sheet passing through the opening. A timer 31 measures a time interval from end of sheet detection by the second sensor to start of sheet detection by the first sensor. A sheet feed interval change unit 33 calculates a reduction amount of the sheet feed interval using the measured values of the timer and changes the sheet feed interval based on the reduction amount each time a predetermined number of the sheets are folded.

Abstract: A sheet folding apparatus includes a sheet folding unit disposed to fold a sheet and a conveyance unit disposed to feed the sheet to the sheet folding unit in a feed direction orthogonal to a fold direction of the sheet folding unit while correcting a skew of the sheet. The conveyance unit includes an elongated reference guide, a conveyance mechanism disposed to convey the sheet in the feed direction while exerting a force on the sheet toward the reference guide, an adjustment mechanism disposed to adjust an inclination of the reference guide with respect to the feed direction. The apparatus further includes an input unit through which a user inputs a folding misalignment amount of the sheet folded by the sheet folding unit. The inclination of the reference guide is corrected by the adjustment mechanism based on at least the folding misalignment amount inputted through the input unit.

Abstract: A first press unit 2 presses each of a plurality of signatures S along a fold f, the signatures being supplied one at a time with the fold facing forward. The unit is arranged a signature conveyance unit 3 that conveys each signature received from the first press unit while controlling the attitude to make the fold orthogonal to the conveyance direction. The unit is arranged a gluing unit 4 that applies glue to both lateral edges of a top surface of each signature received from the signature conveyance unit. The unit is arranged an accumulation unit 5 that sequentially stacks the signatures received from the gluing unit on one another while jogging the stacked signatures to form a book block B. The unit is arranged a second press unit 6 that discharges the book block received from the accumulation unit after pressing the same along the folds.

Abstract: Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.

Abstract: While conveying paper, the paper is folded in a first folding pattern at right angles to the conveyance direction. By bending and rupturing the folded paper, one or multiple perforation lines corresponding to a second folding pattern that is at right angles to the fold(s) are formed in the paper. While conveying the paper with perforations in a direction at right angles to the previous conveyance direction, the paper is folded in the second folding pattern along the perforations, thereby forming a quire.

Abstract: A first press unit 2 presses each of a plurality of signatures S along a fold f, the signatures being supplied one at a time with the fold facing forward. The unit is arranged a signature conveyance unit 3 that conveys each signature received from, the first press unit while controlling the attitude to make the fold orthogonal to the conveyance direction. The unit is arranged a gluing unit 4 that applies glue to both lateral edges of a top surface of each signature received from the signature conveyance unit. The unit is arranged an accumulation unit 5 that sequentially stacks the signatures received from the gluing unit on one another while jogging the stacked signatures to form a book block B. The unit is arranged a second press unit 6 that discharges the book block received from the accumulation unit after pressing the same along the folds.

Abstract: The present invention provides an aptamer that binds to IL-17 to inhibit binding of IL-17 and IL-17 receptor; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a medicament containing the aptamer, or a complex containing the aptamer and a functional substance, a diagnosing drug and labeling agent and the like.

Abstract: The present invention provides an aptamer binding to midkine and capable of forming a potential secondary structure represented by the formula (I): wherein X1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond, X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, and X3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T.

Abstract: A process for producing a caking additive for coke production, the process including a step of extracting a solvent deasphalted pitch that can be used as a caking additive for coke production from a residue containing at least one of an atmospheric residue obtained by atmospheric distillation of a crude oil and a vacuum residue obtained by atmospheric distillation and vacuum distillation of a crude oil, wherein the extraction is performed using, as a solvent, a light reformate obtained by catalytic reforming a naphtha fraction that is fractionated from a crude oil by atmospheric distillation of the crude oil.