Abstract: A microneedle array unit including a microneedle array having a plurality of needle-like protrusions arranged on one surface thereof, a gripping portion provided on a side opposite to the plurality of needle-like protrusions of the microneedle array, and a container configured to accommodate the microneedle array. The container includes an accommodation portion having an opening, a deformable portion disposed on a side opposite to the opening, and a binding portion provided in the accommodation portion of the deformable portion and bound to the gripping portion of the microneedle array. The deformable portion is deformed by receiving an external force in a direction of the opening and presses the microneedle array through the gripping portion, and the microneedle array is pushed out of the accommodation portion by being pressed, and the deformable portion maintains a deformed state and presses the microneedle array.

Abstract: The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying. Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41.

Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

Abstract: Provided are a storage container, a microneedle unit, a storage container group, and a method of producing a microneedle unit that enable protection of a microneedle array before puncture and realization of a puncturing property of the microneedle array using a simple member. The storage container, which stores a microneedle array including a sheet having a first surface and a second surface that oppose each other and a plurality of needles arranged on the first surface of the sheet, includes a first member having an edge portion that defines a second opening and a second member having a depression, in which the microneedle array is stored by superimposing the second member on the first member, and the second member and the first member are deformed by applying a force to the second member in a state in which the second member is superimposed on the first member, and the needles of the microneedle array are allowed to protrude from the first member to puncture a skin.

Abstract: Provided are a mold case that prevents deformation of a microneedle array, and a manufacturing method of a microneedle array. The problems are solved by the manufacturing method of a microneedle array including: a filling step of filling needle-like recessed portions of a mold having flexibility and having a plurality of the needle-like recessed portions on a front surface, with a liquid material; and a drying step of drying the liquid material in a state where the mold filled with the liquid material is stored in the mold case which causes an edge portion of the mold to be sandwiched between the lid and the pedestal.

Abstract: A background image is acquired by imaging an opening plate as a background of an original document in a state where the original document is not arranged. Next, an original document including background image is acquired by imaging the same range as the background image in a state where the original document is arranged on an upper surface of the opening plate. Next, a difference image is generated by subtracting the background image from the original document including background image. In addition, an inverse difference image is generated by subtracting the original document including background image from the background image. A region of the original document is detected based on the difference image and the inverse difference image.

Abstract: The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying. Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41.

Abstract: Provided are a storage container, a microneedle unit, a storage container group, and a method of producing a microneedle unit that enable protection of a microneedle array before puncture and realization of a puncturing property of the microneedle array using a simple member. The storage container, which stores a microneedle array including a sheet having a first surface and a second surface that oppose each other and a plurality of needles arranged on the first surface of the sheet, includes a first member having an edge portion that defines a second opening and a second member having a depression, in which the microneedle array is stored by superimposing the second member on the first member, and the second member and the first member are deformed by applying a force to the second member in a state in which the second member is superimposed on the first member, and the needles of the microneedle array are allowed to protrude from the first member to puncture a skin.

Abstract: A background image is acquired by imaging an opening plate as a background of an original document in a state where the original document is not arranged. Next, an original document including background image is acquired by imaging the same range as the background image in a state where the original document is arranged on an upper surface of the opening plate. Next, a difference image is generated by subtracting the background image from the original document including background image. In addition, an inverse difference image is generated by subtracting the original document including background image from the background image. A region of the original document is detected based on the difference image and the inverse difference image.

Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

Abstract: Provided are a mold case that prevents deformation of a microneedle array, and a manufacturing method of a microneedle array. The problems are solved by the manufacturing method of a microneedle array including: a filling step of filling needle-like recessed portions of a mold having flexibility and having a plurality of the needle-like recessed portions on a front surface, with a liquid material; and a drying step of drying the liquid material in a state where the mold filled with the liquid material is stored in the mold case which causes an edge portion of the mold to be sandwiched between the lid and the pedestal.

Abstract: A bonding target object and a film including a layer having lower toughness than the bonding target object are disposed between a set of pressurization molds, which have pressurization surfaces disposed so as to face each other and in which opening holes are formed in the pressurization surfaces. A first edge on the opening hole side of the pressurization surface of a first pressurization mold, out of the set of pressurization molds, which faces the film is positioned further inside the opening hole than a second edge on the opening hole side of the pressurization surface of a second pressurization mold which faces the bonding target object. The pressing target portion of the film which is pressed by the set of pressurization molds is bonded to the bonding target object by sandwiching the bonding target object and the film with the set of pressurization molds to be pressed.

Abstract: A sheet bonding device includes a pressurization mold which is constituted of an upper mold and a lower mold and performs sealing through heating by sandwiching a sealing target portion of a bag main body and a sealing target portion of a gas barrier function sheet with pressurization surfaces; a plurality of support pins which are provided in the lower mold so as to be retractable and position the gas barrier function sheet with respect to one surface of the bag main body by penetrating the sealing target portions of the bag main body and the gas barrier function sheet; and gas spray means for making the gas barrier function sheet float by spraying inert gas to an area-enlarged portion, which does not overlap the bag main body, of the gas barrier function sheet supported by the support pins.

Abstract: A bonding target object and a film including a layer having lower toughness than the bonding target object are disposed between a set of pressurization molds, which have pressurization surfaces disposed so as to face each other and in which opening holes are formed in the pressurization surfaces. A first edge on the opening hole side of the pressurization surface of a first pressurization mold, out of the set of pressurization molds, which faces the film is positioned further inside the opening hole than a second edge on the opening hole side of the pressurization surface of a second pressurization mold which faces the bonding target object. The pressing target portion of the film which is pressed by the set of pressurization molds is bonded to the bonding target object by sandwiching the bonding target object and the film with the set of pressurization molds to be pressed.