Abstract: A formed body made from a resin and having a wall portion, the wall portion containing, as an oxygen-absorbing component, a non-polymeric oxygen-absorbing organic component in an amount of 0.5 to 2.5% by mass, and having a ratio of oxygen permeation rates expressed by the following formula that is suppressed to be not more than 42%: Ratio of oxygen permeation rates=(P/P0)×100 wherein P is an oxygen permeation rate (cc) through the wall portion, and P0 is an oxygen permeation rate (cc) through the wall portion of the same thickness but without containing the oxygen-absorbing component.

Abstract: An oxygen-absorbing resin composition containing an ethylene terephthalate type polyester resin and an organic oxygen absorber and, further, containing cobalt in an amount of 5 to 50 ppm and titanium in an amount of 1 to 15 ppm calculated as elements.

Abstract: The present invention provides a method for preparing a clinically applicable, safe and less damaged cardiomyocyte population through a brief and simple procedure from a cell population obtained by induced differentiation of pluripotent stem cells into cardiomyocytes. The present invention relates to a method for preparing a cardiomyocyte population, the method comprising the steps of: (1) inducing pluripotent stem cells to differentiate into cardiomyocytes, (2) bringing a cell population obtained by the induced differentiation into contact with a laminin selected from the group consisting of laminin ?2?1?1, laminin ?2?2?1, laminin ?1?1?1 and laminin ?1?2?1, or a fragment thereof having integrin binding activity, and (3) retrieving cells adherent to the laminin or the laminin fragment.

Abstract: An oxygen-absorbing resin composition containing a base resin having a thermoplastic resin; and an oxygen-absorbing component having at least the one selected from the group consisting of an ester, an amide, an imide or a dicarboxylic acid derived from an acid anhydride represented by the following formula (1), wherein, a ring X is an aliphatic ring having an unsaturated bond, n is a number of the substituents Y bonded to the ring X and is an integer of 0 or 1, and Y is an alkyl group, and a polymer having a constituent unit stemming from the acid anhydride. An oxygen-absorbing polyester resin composition exhibits excellent oxygen-absorbing property even in the absence of transition metal catalyst without accompanied by the deterioration of the polyester resin used as a the base resin, the oxygen-absorbing property being strong enough for maintaining gas-barrier properties.

Abstract: A multilayered preform including inner and outer layers of an ethylene terephthalate type polyester resin, and at least one intermediate layer of at least a lowly crystalline ethylene terephthalate type polyester resin and a gas-barrier aromatic polyamide resin, wherein the lowly crystalline ethylene terephthalate type polyester resin contains, as a copolymerizable component, a cyclohexanedimethanol in an amount of 15 to 20 mol % or an isophthalic acid in an amount of 7.5 to 15 mol %, a weight ratio of the lowly crystalline ethylene terephthalate type polyester resin and the gas-barrier aromatic polyamide resin is in a range of 50:50 to 75:25, a weight ratio of the intermediate layer is not less than 1% by weight but is less than 10% by weight per the whole preform, and a haze is not less than 5% in a portion where a multilayered structure has been formed.

Abstract: A method is disclosed for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow, the method maintaining the function of the cardiocytes derived from differentiated pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow, and yet reducing the possibility for tumorigenesis of undifferentiated pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow. A method is also disclosed for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells (derived from adipose tissue or bone marrow, the method including dissociating cells from a cell population which has been induced to differentiate into cardiocytes from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow.

Abstract: The present invention provides a drug-eluting stent graft for preventing stent graft-related complications as well as treating aneurysm. Specifically, the present invention relates to a drug-eluting stent graft comprising a drug, a drug-retaining agent and a stent graft, and a method for therapy of aneurysm including the use of the drug-eluting stent graft.

Abstract: An oxygen-absorbing resin composition including a base resin (A) which is a thermoplastic resin, an oxygen-absorbing component (B) which is a compound having an unsaturated alicyclic structure, and an oxidation promotion component (C) for promoting the oxidation of the oxygen-absorbing component (B); wherein the oxygen-absorbing component (B) is an imide compound having a molecular weight of not more than 2,000 and obtained by heat-treating an amide having been obtained by reacting an acid anhydride represented by the following formula (1): wherein the ring X is an alicyclic ring having an unsaturated bond, and Y is an alkyl group, with an aromatic amine, and wherein the oxidation promotion component (C) is a compound having a benzyl hydrogen.

Abstract: Methods are disclosed of freezing, cryopreserving, and transferring a frozen sheet-shaped cell culture. The method of freezing includes (1) a step of immersing in a cryopreservation solution a sheet-shaped cell culture supported by a mesh-shaped support body; (2) a step of removing the cryopreservation solution adhered to the sheet-shaped cell culture, while keeping the sheet-shaped cell culture supported by the mesh-shaped support body; (3) a step of enclosing the sheet-shaped cell culture in a cold-resistant film, an upper surface and a lower surface of the sheet-shaped cell culture being covered by the mesh-shaped support body; and (4) a step of freezing the sheet-shaped cell culture.

Abstract: Disclosed is a cell mass containing an adipose-tissue-derived multipotent progenitor cell. Also disclosed is a method for producing an adipose-tissue-derived multipotent progenitor cell from an adipose tissue, which comprises the steps of: (a) removing erythrocytes from an adipose-tissue-derived cell mass to produce a preadipose-tissue-derived multipotent progenitor cell mass; and (b) removing cells other than the adipose-tissue-derived multipotent progenitor cell from the preadipose-tissue-derived multipotent progenitor cell mass to produce the desired adipose-tissue-derived multipotent progenitor cell. Further disclosed is an adipose-tissue-derived multipotent progenitor cell produced by the method.

Abstract: Provided is a cell population comprising differentiated cells obtainable by inducing differentiation of pluripotent stem cells, wherein the content ratio of undifferentiated pluripotent stem cells is 0.2% or less.

Abstract: A method for treating a disease associated with tissue abnormality in a subject. The method includes administering an amount of a pharmaceutical composition to a subject in need of treating a disease associated with tissue abnormality, the pharmaceutical composition comprising a laminate comprising a fibrin gel and a cell culture. The laminate is produced by a method, which includes forming a fibrin gel layer on an upper surface of the cell culture by a reaction between fibrinogen and thrombin, wherein: the cell culture is prepared on a culture dish and the laminate of the fibrin gel and the cell culture are transferred onto a subject's heart. The laminate further includes a reinforcing portion made of a fibrin gel, the reinforcing portion formed by laminating the fibrin gel on the fibrin gel layer of the laminate of the cell culture and the fibrin gel.

Abstract: To provide an oxygen-absorbing polyester resin composition which exhibits excellent oxygen-absorbing capability even in the absence of transition metal catalyst without affected by the glass transition temperature of a polyester resin that is contained as a base resin. The oxygen-absorbing polyester resin composition including a base resin (A) which is a polyester resin, an oxygen-absorbing component (B) which is a compound having an unsaturated alicyclic structure, and an oxidation promotion component (C) for promoting the oxidation of the oxygen-absorbing component (B), said oxidation promotion component (C) being a compound having a benzyl hydrogen.

Abstract: A sheet-shaped cell culture is disclosed that includes myocardial cells derived from pluripotent stem cells and has excellent functional properties. A sheet-shaped cell culture obtained by culturing a cell population that includes myocardial cells derived from pluripotent stem cells, wherein the proportion of the number of the myocardial cells derived from pluripotent stem cells to the total number of cells in the cell population is 50% to 70%; a method of producing the sheet-shaped cell culture; a composition including the sheet-shaped cell culture; and a method of treating a disease using the sheet-shaped cell culture or the composition.

Abstract: A laminate of a sheet-shaped cell culture is disclosed, which has excellent operability and is suitable for implantation. A method is disclosed for producing a laminate of a fibrin gel and a sheet-shaped cell culture, including a step of dripping a liquid containing fibrinogen onto an upper surface of a sheet-shaped cell culture, a step of spraying a liquid containing thrombin onto the surface, and a step of forming a fibrin gel layer on the surface by a reaction between fibrinogen and thrombin; and a laminate of a fibrin gel and a sheet-shaped cell culture produced by the method are disclosed.

Abstract: A fragment peptide having a proper length composed of a part of an HMGB1 protein was synthesized and the peptide was confirmed to exhibit therapeutic effects on myocardial infarction.

Abstract: Provided is an advanced heart failure treatment material, as a myocardial/cardiovascular regeneration device, that self-assembles, which can improve the universality and be used in an emergency by commercialization with no need of cell-culturing (cell-free) by controlling stem cells, and has a high therapeutic effect on the fundamental treatment of intractable cardiovascular diseases, in particular, advanced heart failure, in which not only the saving of lives but also improving the patient's quality of life (QOL) are urgent issues. The advanced heart failure treatment material includes a pharmaceutical agent, an agent holding for the pharmaceutical agent, and a myocardial support device.

Abstract: An oxygen-absorbing resin composition containing (A) a base material which comprises a thermoplastic resin; (B) a bisimide compound derived from a tetrahydrophthalic anhydride and an aliphatic diamine; and (C) a transition metal catalyst; wherein the bisimide compound (B) is contained in amounts of 0.1 to 10.0% by weight, and the transition metal catalyst (C) is contained in amounts of 10 to 350 ppm calculated as metal. Despite of containing an organic oxygen absorber, the oxygen-absorbing resin composition of the invention is free from the problem of yellowing caused by the absorption of oxygen.

Abstract: The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.

Abstract: The present invention aims to provide an artificial tissue that can efficiently reproduce myocardial tissue function and that can be used in an actual implantation and produced by culturing. The present invention relates to a graft material for treating myocardial disease, the graft material including a cell sheet containing adipocytes.