Abstract: Transdermal anti-dementia active agent systems are provided. Aspects of systems include a transdermal preparation, first overlay and second overlay. Also provided are methods of using the systems, e.g. for administering an anti-dementia active agent to a subject.

Abstract: A transdermal extended-delivery donepezil active agent composition is provided. Aspects of the compositions of the invention include a donepezil active agent layer that is formulated to provide for multi-day delivery of a therapeutically effective amount of a donepezil active agent to a subject when the composition is topically applied to the subject. Also provided are methods of using the formulations, e.g., for administering a donepezil active agent to a subject, and kits containing the formulations.

Abstract: A transdermal antidementia active agent formulation is provided. In certain embodiments, the formulation includes a backing, an active agent reservoir layer including an antidementia active agent, wherein the antidementia active agent is present as both a freebase and optionally also present as a salt, an adhesive layer including the antidementia active agent, and optionally an adhesive overlay. Also provided are methods of using the formulations, e.g. for administering an antidementia active agent to a subject, and kits containing the formulations.

Abstract: An electrotransport system for delivery of an electrotransport cationic drug. The system has an anode that has a precipitating anion source. The precipitating anions from the precipitating anion source combines with metal ions generated from sacrificial metal of the anode during electrotransport to form precipitates. Metal that can form the metal ions are embedded in the anode.