Patents by Inventor Yoshimasa Fukuda
Yoshimasa Fukuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9975851Abstract: A method for producing a compound represented by formula (I) comprises the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of trifluoroacetic acid as an acylating agent to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B), as followsType: GrantFiled: March 4, 2015Date of Patent: May 22, 2018Assignee: MEIJI SEIKA PHARMA CO., LTD.Inventors: Nozomu Nakanishi, Shigeki Kitsuda, Yoshimasa Fukuda
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Patent number: 9883673Abstract: To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): [where Ar represents a phenyl group or a 5- to 6-membered heterocycle, R1 represents a C1-6 alkyl group, and Y represents a hydrogen atom; a halogen atom; a hydroxyl group; a C1-6 alkyl group which may be substituted with a halogen atom; a C1-6 alkyloxy group which may be substituted with a halogen atom; a cyano group; a formyl group; or a nitro group].Type: GrantFiled: April 29, 2016Date of Patent: February 6, 2018Assignee: MEIJI SEIKA PHARMA CO., LTD.Inventors: Nozomu Nakanishi, Yoshimasa Fukuda, Shigeki Kitsuda, Ikuya Ohno
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Publication number: 20170073312Abstract: A method for producing a compound represented by formula (I) comprises the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of trifluoroacetic acid as an acylating agent to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B), as followsType: ApplicationFiled: March 4, 2015Publication date: March 16, 2017Applicant: MEIJI SEIKA PHARMA CO., LTD.Inventors: Nozomu NAKANISHI, Shigeki KITSUDA, Yoshimasa FUKUDA
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Publication number: 20160242415Abstract: To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): [where Ar represents a phenyl group or a 5- to 6-membered heterocycle, R1 represents a C1-6 alkyl group, and Y represents a hydrogen atom; a halogen atom; a hydroxyl group; a C1-6 alkyl group which may be substituted with a halogen atom; a C1-6 alkyloxy group which may be substituted with a halogen atom; a cyano group; a formyl group; or a nitro group].Type: ApplicationFiled: April 29, 2016Publication date: August 25, 2016Applicant: MEIJI SEIKA PHARMA CO., LTD.Inventors: Nozomu NAKANISHI, Yoshimasa FUKUDA, Shigeki KITSUDA, Ikuya OHNO
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Patent number: 9357776Abstract: To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): [where Ar represents a phenyl group or a 5-to 6-membered heterocycle, R1 represents a C1-6 alkyl group, and Y represents a hydrogen atom; a halogen atom; a hydroxyl group; a C1-6 alkyl group which may be substituted with a halogen atom; a C1-6 alkyloxy group which may be substituted with a halogen atom; a cyano group; a formyl group; or a nitro group].Type: GrantFiled: August 24, 2012Date of Patent: June 7, 2016Assignee: MEIJI SEIKA PHARMA CO., LTD.Inventors: Nozomu Nakanishi, Yoshimasa Fukuda, Shigeki Kitsuda, Ikuya Ohno
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Patent number: 8853413Abstract: Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.Type: GrantFiled: May 12, 2010Date of Patent: October 7, 2014Assignee: Meiji Seika Pharma Co., Ltd.Inventors: Yoshimasa Fukuda, Takashi Ando, Kimihiko Goto, Nozomu Nakanishi, Takashi Watanabe, Kenichi Kurihara, Nobuto Minowa, Masaaki Mitomi
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Patent number: 8853414Abstract: Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.Type: GrantFiled: November 10, 2010Date of Patent: October 7, 2014Assignee: Meiji Seika Pharma Co., Ltd.Inventors: Yoshimasa Fukuda, Takashi Ando, Kimihiko Goto, Nozomu Nakanishi, Takashi Watanabe, Kenichi Kurihara, Nobuto Minowa, Masaaki Mitomi
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Publication number: 20140213791Abstract: To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): [where Ar represents a phenyl group or a 5-to 6-membered heterocycle, R1 represents a C1-6 alkyl group, and Y represents a hydrogen atom; a halogen atom; a hydroxyl group; a C1-6 alkyl group which may be substituted with a halogen atom; a C1-6 alkyloxy group which may be substituted with a halogen atom; a cyano group; a formyl group; or a nitro group].Type: ApplicationFiled: August 24, 2012Publication date: July 31, 2014Applicant: MEIJI SEIKA PHARMA CO., LTD.Inventors: Nozomu Nakanishi, Yoshimasa Fukuda, Shigeki Kitsuda, Ikuya Ohno
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Publication number: 20130131091Abstract: The present invention provides a composition for use as a harmful organism control agent comprising as an active ingredient one or more of compounds represented by formula (I) or salts thereof and an agriculturally or zootechnically acceptable carrier. wherein Het represents pyridyl; X represents an oxygen atom; R1, R2, R3, R7, R10a, R10b, R11, and R12 represent a hydrogen atom; R4, R5, and R6 represent a hydrogen atom, hydroxyl, optionally substituted C1-18 alkylcarbonyloxy, optionally substituted C1-18 alkylsulfonyloxy, optionally substituted arylcarbonyloxy, C1-6 alkyloxy-C1-6 alkyloxy, C1-6 alkyloxy-C1-6 alkyloxy-C1-6 alkyloxy; R8 represents a hydrogen atom; and R13a, R13b, and R13c represent methyl.Type: ApplicationFiled: May 23, 2011Publication date: May 23, 2013Inventors: Kimihiko Goto, Ryo Horikoshi, Kazuhiko Oyama, Yoshimasa Fukuda, Nozomu Nakanishi, Masato Tani, Nobuto Minowa, Masaaki Mitomi, Satoshi Omura, Toshiaki Sunazuka, Hiroshi Tomoda
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Publication number: 20130060042Abstract: Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.Type: ApplicationFiled: November 10, 2010Publication date: March 7, 2013Inventors: Yoshimasa Fukuda, Takashi Ando, Kimihiko Goto, Nozomu Nakanishi, Takashi Watanabe, Kenichi Kurihara, Nobuto Minowa, Masaaki Mitomi
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Publication number: 20120046470Abstract: Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.Type: ApplicationFiled: May 12, 2010Publication date: February 23, 2012Inventors: Yoshimasa Fukuda, Takashi Ando, Kimihiko Goto, Nozomu Nakanishi, Takashi Watanabe, Kenichi Kurihara, Nobuto Minowa, Masaaki Mitomi
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Patent number: 5922724Abstract: The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, phenyl, halogen, CF.sub.3, amino, nitro, cyano, acyl, acylamino, phenyl and monocyclic heteroaryl; andone of R.sup.6 and R.sup.7 is hydrogen and the other is furanyl or isoxazolyl each of which may be substituted one or more times with substituents selected from halogen, alkyl, alkoxy and phenyl. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.Type: GrantFiled: February 5, 1998Date of Patent: July 13, 1999Assignees: Neurosearch A/S, Meiji Seika Kaisha, Ltd.Inventors: Lene Teuber, Frank Watjen, Yoshimasa Fukuda, Osamu Ushiroda, Toshiro Sasaki
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Patent number: 5922725Abstract: The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl, all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, halogen, CF.sub.3, amino, nitro, cyano, acylamino, acyl, phenyl and monocyclic heteroaryl;one of R.sup.6 and R.sup.7 is hydrogen and the other is --CR'.dbd.NOR", wherein R' and R" each independently are hydrogen, alkyl, alkenyl, alkynyl or phenyl.The compounds are useful for the treartment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.Type: GrantFiled: December 23, 1997Date of Patent: July 13, 1999Assignees: Neurosearch A/S, MeijI Seika Kaisha, Ltd.Inventors: Lene Teuber, Frank Watjen, Yoshimasa Fukuda, Osamu Ushiroda, Toshiro Sasaki
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Patent number: 5599815Abstract: Compounds represented by the formula (I) and pharmacologically acceptable salts thereof: ##STR1## These compounds have little extrapyramidal effect and thus are effective as an anti-psychotic agent having few side effects.Type: GrantFiled: December 20, 1994Date of Patent: February 4, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Yoshimasa Fukuda, Toshiro Sasaki, Yuuko Nakatani, Yasuyuki Ichimaru, Taiichiro Imanishi
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Patent number: 5449694Abstract: (-)-Ritodrine, that is (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-propan ol or a salt thereof substantially free from the (+)-isomer is disclosed. The compound has a strong suppressive effect on uterine contraction in comparison with (.+-.)-ritodrine and (+)-ritodrine and has the same level of toxicity as these compounds, so that it can be used as a therapeutic agent of threatened premature birth and threatened abortion as well as a therapeutic agent of dysmenorrhea having a high safety.Type: GrantFiled: March 1, 1994Date of Patent: September 12, 1995Assignee: Meiji Seika Kabushiki KaishaInventors: Naoki Yamazaki, Yoshimasa Fukuda, Yoshiaki Shibazaki, Tetsutarou Niizato, Isao Kosugi, Shin Yoshioka
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Patent number: 5118784Abstract: Disclosed is a poly-.gamma.-glutamic acid ester comprising recurring units represented by the following formula (A): ##STR1## wherein R represents an ester-forming group, and recurring units represented by the following formula (B): ##STR2## wherein the former units (A) occupy at least 40% and the polymerization degree, that is, the total number of both the units (A) and (B), is at least 1000.Type: GrantFiled: February 8, 1991Date of Patent: June 2, 1992Assignee: Meiji Seika Kabushiki KaishaInventors: Hidetoshi Kubota, Yoshimasa Fukuda, Hidehi Takebe, Takeshi Endo
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Patent number: 5018812Abstract: An optical switching device having an organic thin film selectively enabling optical transmission and cut-off of infrared light of a predetermined wavelength by changing applied potential.Type: GrantFiled: October 30, 1989Date of Patent: May 28, 1991Assignee: Texas Instruments IncorporatedInventor: Yoshimasa Fukuda