Patents by Inventor Yoshimasa Oiji
Yoshimasa Oiji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5075301Abstract: A furan derivative and a pharmaceutically acceptable salt thereof having gastrointestinal enterokinetic activity which is expected to be used in a broad spectrum of diseases associated with gastrointestinal dyskinesia.Type: GrantFiled: August 14, 1990Date of Patent: December 24, 1991Assignee: Kyowa Hakko Kogyo, Co., Ltd.Inventors: Setsuya Sasho, Shunji Ichikawa, Hiromasa Kato, Hiroyuki Obase, Katsuichi Shuto, Yoshimasa Oiji
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Patent number: 4851414Abstract: Disclosed are anti-dementia agents comprising an antiamnestically effective amount of a benzylpyridine derivative of the formula ##STR1## wherein R is an alkyl group. The invention also pertains to the treatment of dementia by administration of such anti-dementia agent.Type: GrantFiled: August 8, 1988Date of Patent: July 25, 1989Assignee: Kyowa Hakko Kagyo Co., Ltd.Inventors: Shizuo Shiozaki, Katsuichi Shuto, Yoshimasa Oiji
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Patent number: 4849441Abstract: Isoindolin-1-one compounds represented by the following formula (I); ##STR1## {wherein n represents an integer of 1 to 6; m represents 0 or 1; R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen or lower alkyl, and when m is 1, R.sub.1 and one of R.sub.2 and R.sub.3 may form a five-membered or six-membered ring over N atom; X represents hydrogen or hydroxy; Ar represents naphthyl, pyridyl or substituted phenyl represented by the formula (II); Ar and X may form a lactone ring; ##STR2## [wherein Y represents carboxyl, lower alkoxycarbonyl, carbamoyl, N,N-lower alkyl-substituted carbamoyl or amino represented by the formula (III): ##STR3## (wherein R.sub.6 and R.sub.7 are each independently hydrogen, lower alkyl or lower alkanoyl); R.sub.4 and R.sub.5 are each independently hydrogen, lower alkyl, cyano or halogen]} or a pharmaceutically acceptable acid addition salt or metal salt thereof have an excellent antiarrhythmic activity.Type: GrantFiled: December 22, 1987Date of Patent: July 18, 1989Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kei Okazaki, Etsuo Oshima, Hiroyuki Obase, Yoshimasa Oiji, Masaaki Nito, Kazuhiro Kubo
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Patent number: 4596804Abstract: A dibenz[b,e]oxepin compound having an antiallergic activity is represented by the following general formula: ##STR1## wherein R.sub.1 represents a cyano group, a 5-tetrazolyl group, a carbamoyl group or --CO.sub.2 R.sub.3 wherein R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or a 1-(ethoxycarbonyloxy)ethyl group, and R.sub.2 represents a 4-alkylpiperazino group wherein the alkyl group has 1 to 5 carbon atoms, a 3-quinuclidinylamino group or --X--(CH.sub.2).sub.n --NR.sub.4 R.sub.5 wherein X represents --NH--, --S -- or --O--, R.sub.4 and R.sub.5 are same or different and each represents an alkyl group having 1 to 5 carbon atoms and n represents 2 or 3; and the pharmaceutically acceptable acid addition salts or metal salts thereof.Type: GrantFiled: June 26, 1984Date of Patent: June 24, 1986Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Yoshimasa Oiji, Kenji Ohmori, Katsuichi Shuto
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Patent number: 4547496Abstract: A novel [1] benzepino[3,4-b]pyridine derivative having antiulcer activity is represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group, a halogenated alkyl group, an alkoxy group or a halogen atom; R.sup.2 represents ##STR2## wherein Y represents an amino group, a substituted amino group, a heterocyclic group or a substituted heterocyclic group; Z represents a hydrogen atom, an alkyl group or an acyl group; and m is an integer of 1-3, ##STR3## wherein Z' represents a hydrogen atom or an alkyl group; Y has the same meaning as defined above, and n is 0, 1 or 2; or ##STR4## wherein Z and n have the same meanings as defined above; X represents an oxygen atom or a sulfur atom. Also disclosed are pharmaceutically acceptable acid addition salts of the compound represented by the formula (I).Type: GrantFiled: June 21, 1984Date of Patent: October 15, 1985Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiaki Kumazawa, Yoshimasa Oiji, Hiroshi Tanaka, Katsuichi Shuto
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Patent number: 4465835Abstract: Novel dibenz [b,e] oxepin derivatives represented by the general formula: ##STR1## wherein R.sub.11 represents an alkyl group containing 1 to 5 carbon atoms, an alkoxy group containing 1 to 5 carbon atoms, a halogen atom, a cyclohexyl group or a phenyl group; and R.sub.21 represents ##STR2## wherein X represents a hydrogen atom, a hydroxy group, an amino group or a substituted aralkyl group containing 7 to 20 carbon atoms, and n represents 0 or an integer of 1 to 3 ##STR3## wherein Y represents an alkylamino group containing 1 to 5 carbon atoms, an aralkyl group containing 7 to 20 carbon atoms, a substituted aralkyl group, an aralkyloxy group containing 7 to 20 carbon atoms, an aralkylamino group containing 7 to 20 carbon atoms, a heterocyclic ring or a substituted heterocyclic ring, and n has the same meaning as defined before; provided that when R.sub.Type: GrantFiled: April 19, 1983Date of Patent: August 14, 1984Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Osamu Morita, Yoshimasa Oiji, Tamotsu Hashimoto
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Patent number: 4450115Abstract: New amino-alcohol derivatives and processes for production thereof are disclosed. These compounds exhibit .alpha. and .beta.-adrenergic receptor blocking activity or they act to increase the flow of blood of certain organs.Type: GrantFiled: July 9, 1981Date of Patent: May 22, 1984Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Yoshimasa Oiji, Kazuhiro Kubo
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Patent number: 4396550Abstract: Novel dibenz [b,e] oxepin derivatives represented by the general formula: ##STR1## wherein R.sub.11 represents an alkyl group containing 1 to 5 carbon atoms, an alkoxy group containing 1 to 5 carbon atoms, a halogen atom, a cyclohexyl group or a phenyl group; and R.sub.21 represents ##STR2## wherein X represents a hydrogen atom, a hydroxy group, an amino group or a substituted aralkyl group containing 7 to 20 carbon atoms, and n represents 0 or an integer of 1 to 3 ##STR3## or (3) --NH--(CH.sub.2).sub.n --Y, wherein Y represents an alkylamino group containing 1 to 5 carbon atoms, an aralkyl group containing 7 to 20 carbon atoms, a substituted aralkyl group, an aralkyloxy group containing 7 to 20 carbon atoms, an aralkylamino group containing 7 to 20 carbon atoms, a heterocyclic ring or a substituted heterocyclic ring, and n has the same meaning as defined before; provided that when R.sub.Type: GrantFiled: April 21, 1981Date of Patent: August 2, 1983Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Osamu Morita, Yoshimasa Oiji, Tamotsu Hashimoto
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Patent number: 4381398Abstract: New amino-alcohol derivatives and processes for production thereof are disclosed. These compounds exhibit .alpha. and .beta.-adrenergic receptor blocking activity or they act to increase the flow of blood of certain organs.Type: GrantFiled: March 18, 1980Date of Patent: April 26, 1983Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Yoshimasa Oiji, Kazuhiro Kubo
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Patent number: 4353923Abstract: A pharmaceutical composition, specifically a muscle relaxant acting at the same time as an anti-inflammatory and analgesic agent which composition comprises pharmaceutically acceptable carrier(s) and a benzo[b]furancarboxamide derivative represented by the general formula: ##STR1## wherein R represents a halogen atom, an alkyl group having 1-5 carbon atoms or an alkoxy group having 1-5 carbon atoms.Type: GrantFiled: July 17, 1981Date of Patent: October 12, 1982Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Yoshimasa Oiji, Tatsuyuki Hirayama
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Patent number: 4297369Abstract: The present invention relates to certain novel benzo[b]furan derivatives, namely, 5-substituted-2-substituted carbamoylmethyl-3-methyl benzo[b]furan having interesting pharmacological properties, in particular a muscle relaxant activity.Type: GrantFiled: July 28, 1980Date of Patent: October 27, 1981Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Yutaka Enomoto, Yoshimasa Oiji, Tatsuyuki Hirayama, Tamotu Hashimoto
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Patent number: 4172145Abstract: This invention relates to certain derivatives of benzo (b) furylacetic acid, namely, 5-substituted-3-methyl-2-benzo(b)furylacetic acids having interesting pharmacological properties, in particular an antiphlogistic and analgesic activity.Type: GrantFiled: February 15, 1978Date of Patent: October 23, 1979Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Shigetaka Yoshina, deceased, Tsutomu Kameyama, Yoshimasa Oiji, Akira Kiyohara
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Patent number: 4126625Abstract: This invention relates to certain derivatives of benzo (b) furylacetic acid, namely, 5-substituted-3-methyl-2-benzo(b)furylacetic acids having interesting pharmacological properties, in particular an antiphlogistic and analgesic activity.Type: GrantFiled: July 12, 1976Date of Patent: November 21, 1978Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Shigetaka Yoshina, deceased, by Teruko Yoshina, legal heir, Tsutomu Kameyama, Yoshimasa Oiji, Akira Kiyohara