Abstract: A novel interleukin-18 (IL-18) variant and a pharmaceutical composition using the same, which relates to a human IL-18 variant including (i) mutations of cysteine at positions 38, 68, 76, and 127 into serine and (ii) mutations of glutamic acid at position 6 and lysine at position 53 into alanine relative to an amino acid sequence of wild-type human IL-18, where the variant further includes (iii) at least one additional mutation, and a pharmaceutical composition containing the human IL-18 variant.

Abstract: An induction heating device is provided. The induction heating device comprises a plurality of induction heating devices disposed at intervals along the circumference of a ring-shaped workpiece, a setting unit for setting induction heating conditions, and a switching control unit. Each of the plurality of induction heating devices comprises heating coils disposed facing areas to be heated of the workpiece, a plurality of transformers connected to the heating coils in parallel, a plurality of matching units connected to any one of the plurality of transformers, an inverter unit having a rectifier unit and an inverter unit, an inverter control unit having a rectification control unit, and a group of switches.

Abstract: An induction heating device is provided. The induction heating device comprises a plurality of induction heating devices disposed at intervals along the circumference of a ring-shaped workpiece, a setting unit for setting induction heating conditions, and a switching control unit. Each of the plurality of induction heating devices comprises heating coils disposed facing areas to be heated of the workpiece, a plurality of transformers connected to the heating coils in parallel, a plurality of matching units connected to any one of the plurality of transformers, an inverter unit having a rectifier unit and an inverter unit, an inverter control unit having a rectification control unit, and a group of switches.

Abstract: If a distance from a current position to a guide point is less than a predetermined distance, a normal output process and a stop process of a guide image are repeatedly performed. If a priority display request for a guide image is performed, a priority output process of the guide image is performed prior to the stop process. If an interval between the priority output process and the normal output process performed after the priority output process is short, the priority output process continues until the normal output process starts.

Abstract: A heating apparatus and a heating method are provided. The heating apparatus includes a coil configured to receive AC power to form a magnetic field that inductively heats a workpiece, a spray unit configured to spray cooling fluid including a liquid to the coil in a form of mist at least during a period in which the AC power is supplied to the coil. Alternatively, the spray unit may be configured to spray the cooling fluid in the form of mist to a heating target portion of the workpiece placed in the magnetic field at least during the period in which the AC power is supplied to the coil.

Abstract: A heating apparatus and a heating method are provided. The heating apparatus includes a coil configured to receive AC power to form a magnetic field that inductively heats a workpiece, a spray unit configured to spray cooling fluid including a liquid to the coil in a form of mist at least during a period in which the AC power is supplied to the coil. Alternatively, the spray unit may be configured to spray the cooling fluid in the form of mist to a heating target portion of the workpiece placed in the magnetic field at least during the period in which the AC power is supplied to the coil.

Abstract: A method may predict risk of onset of severe interstitial pneumonia caused by an immune checkpoint inhibitor to achieve a safe and highly effective cancer immunotherapy. Any one or more selected from: (a) cell count or proportion of V?2+?? T cells in peripheral blood mononuclear cells isolated from a subject; (b) cell count or proportion of V?2+?? T cells after antigenic stimulation in peripheral blood mononuclear cells isolated from a subject; (c) cell count or proportion of V?2+?? T cells in peripheral blood T cells isolated from a subject; and (d) cell count or proportion of V?2+?? T cells after antigenic stimulation in peripheral blood T cells isolated from a subject are measured, and the risk of onset of severe interstitial pneumonia is predicted by using the cell count or proportion as an index.

Abstract: In a helmet including a battery and a helmet body whose outer surface is constituted by a shell, a charging connector is disposed inside the shell to face inward of the shell, and the charging connector is configured to be connected to a power supply-side connector connected to a power supply through a power supply-side cable during charging of the battery.

Abstract: If a distance from a current position to a guide point is less than a predetermined distance, a normal output process and a stop process of a guide image are repeatedly performed. If a priority display request for a guide image is performed, a priority output process of the guide image is performed prior to the stop process. If an interval between the priority output process and the normal output process performed after the priority output process is short, the priority output process continues until the normal output process starts.

Abstract: A heating coil is configured to induction heat a workpiece having a hole. The heating coil includes first and second heating units respectively having conductors. The conductors of the first and second heating units extend in inclination directions intersecting an axial direction and a circumferential direction of an outer peripheral surface of the workpiece.

Abstract: The present invention provides a method for efficiently producing highly pure ??T cells introduced with foreign genes by culturing in the presence of IL-7 and IL-15 after stimulating the ??T cells with a bisphosphonic acid ester derivative. When a T cell receptor (TCR) or a chimeric antigen receptor (CAR) is introduced as a foreign gene, ??T cells in which TCR and CAR are functionally expressed can be obtained.

Abstract: An induction heating device is provided. The induction heating device comprises a plurality of induction heating devices disposed at intervals along the circumference of a ring-shaped workpiece, a setting unit for setting induction heating conditions, and a switching control unit. Each of the plurality of induction heating devices comprises heating coils disposed facing areas to be heated of the workpiece, a plurality of transformers connected to the heating coils in parallel, a plurality of matching units connected to any one of the plurality of transformers, an inverter unit having a rectifier unit and an inverter unit, an inverter control unit having a rectification control unit, and a group of switches.

Abstract: A heating coil of a heat treatment apparatus is configured to inductively heat an elongated workpiece having a recessed lateral surface. The heating coil includes a base conductor and a projected conductor. A width of the projected conductor is narrower than a width of the base conductor. The projected conductor is arranged to project toward the recess from a position of the base conductor. The base conductor and the projected conductor are arranged to extend in a longitudinal direction of the workpiece. A heat treatment apparatus includes a cooling section and the heating coil. A heat treatment method uses the heating coil described above.

Abstract: An induction heating device and an induction heating method are provided. The entire areas to be heated of the workpiece can be uniformly heated to a predetermined high temperature, and uniform heating is possible even when the workpiece deforms in a non-uniform manner during heating. When areas to be heated are established on a workpiece so as to extend in one direction and the areas to be heated are induction-heated, the deformation amount on one edge of the areas to be heated is different from that on the other. This induction heating device includes; heating coils facing a portion of the areas to be heated when the workpiece is induction-heated; and a relative transfer means for transferring the workpiece and the heating coils along one direction in a relative manner, and the heating coils are disposed so as to correspond to the areas to be heated during the heating period.

Abstract: An induction heating device and an induction heating method are provided. The entire areas to be heated of the workpiece can be uniformly heated to a predetermined high temperature, and uniform heating is possible even when the workpiece deforms in a non-uniform manner during heating. When areas to be heated are established on a workpiece so as to extend in one direction and the areas to be heated are induction-heated, the deformation amount on one edge of the areas to be heated is different from that on the other. This induction heating device includes; heating coils facing a portion of the areas to be heated when the workpiece is induction-heated; and a relative transfer means for transferring the workpiece and the heating coils along one direction in a relative manner, and the heating coils are disposed so as to correspond to the areas to be heated during the heating period.

Abstract: In preferred embodiments, a heating coil is provided that includes at least a set of heating conductors, one of which is arranged at a side of a work and the other one is arranged at an opposite side of the work. In addition, a plurality of connecting conductors are provided to connect an end of one of the heating conductors with an end of the other heating conductor, wherein each of the heating conductors is connected with at least two connecting conductors. The connecting conductors extend from an end of each of the heating conductor in a different direction from each other. In the preferred embodiments, the heating coil has a simple structure that enables an even heat treatment to a work in a width direction.

Abstract: According to an embodiment, an induction heating coil includes a heating conductor portion which is formed of a conductor member and has a zigzag shape in which a bent portion opened to one side in a first direction and a bent portion opened to the other side in the first direction are alternately continuously arranged in opposite directions along a second direction crossing the first direction.

Abstract: The novel bisphosphonic acid ester derivatives represented by the following formula (1): Y—Cy—(NH)m—(CH2)n—C(X)(PO(OR1)(OR2))2??(1) wherein each symbol is as defined in the DESCRIPTION, which has an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom, and the acid moiety is esterified with a POM group, an n-butanoyloxymethyl (BuOM) group and the like, exhibit a superior direct or indirect cytotoxicity effect on tumor cells and virus infected cells.

Abstract: A heating apparatus and a heating method are provided. The heating apparatus includes a coil configured to receive AC power to form a magnetic field that inductively heats a workpiece, a spray unit configured to spray cooling fluid including a liquid to the coil in a form of mist at least during a period in which the AC power is supplied to the coil. Alternatively, the spray unit may be configured to spray the cooling fluid in the form of mist to a heating target portion of the workpiece placed in the magnetic field at least during the period in which the AC power is supplied to the coil.

Abstract: A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P—C(F)—P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood ?? T cells that express V?2V?2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by ?? T cells.