Patents by Inventor Yoshimi Kawamura
Yoshimi Kawamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6103231Abstract: Novel antibiotic stalobacins H-1 and I-1 having physico-chemical properties as shown in Table 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.Type: GrantFiled: December 9, 1997Date of Patent: August 15, 2000Assignee: Shionogi & Co., Ltd.Inventors: Shigeru Matsutani, Tadashi Yoshida, Ryuji Sakazaki, Koichi Matsumoto, Shigeo Yagi, Bunji Kageyama, Yoshimi Kawamura, Toshiyuki Kamigauchi, Susumu Kamata
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Patent number: 5876984Abstract: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt, or a hydrate thereof, a process for preparing said compound, and a pharmaceutical composition having antiviral activity which comprise said compound.Type: GrantFiled: March 20, 1998Date of Patent: March 2, 1999Assignee: Shionogi & Co., LtdInventors: Toshiyuki Kamigauchi, Tamio Fujiwara, Hiroyoshi Tani, Yoshimi Kawamura, Isao Horibe
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Patent number: 5762012Abstract: A sewing machine which includes a main shaft motor for driving a main shaft; a needle bar for moving up and down by rotation of the main shaft motor; a thread exchanging mechanism, having a swinging member swingable by rotation of the main shaft motor, for exchanging a thread by moving a thread barrel having an opening through which a thread is passed, from a standby position to an exchange position; and a controller for controlling the rotation of the main shaft motor.Type: GrantFiled: February 26, 1997Date of Patent: June 9, 1998Assignee: Aisin Seiki Kabushiki KaishaInventors: Yoshimi Kawamura, Moriya Ochi
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Patent number: 5456910Abstract: Novel antibiotic stalobacins A to I having physico-chemical properties as shown in Tables 1 to 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.Type: GrantFiled: May 17, 1994Date of Patent: October 10, 1995Assignee: Shionogi & Co., Ltd.Inventors: Shigeru Matsutani, Tadashi Yoshida, Ryuji Sakazaki, Koichi Matsumoto, Shigeo Yagi, Bunji Kageyama, Yoshimi Kawamura, Toshiyuki Kamigauchi, Susumu Kamata
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Patent number: 5324742Abstract: The present invention relates to a novel aldose reductase inhibitor of the formula: ##STR1## wherein X is methylene or carbonyl;R is ##STR2## R.sup.1, R.sup.2, R.sup.3, and R.sup.4 each is hydrogen or lower alkyl, to a method for producing the inhibitor by culturing Crucibulum sp. RF-3817 or its variants, and to an agent for inhibiting an aldose reductase comprising the inhibitor.Type: GrantFiled: May 8, 1991Date of Patent: June 28, 1994Assignee: Shionogi & Co., Ltd.Inventors: Tadashi Yoshida, Toshiyuki Kato, Yoshimi Kawamura, Koichi Matsumoto, Hiroshi Itazaki
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Patent number: 5314911Abstract: The present invention relates to a compound represented by the formula I: ##STR1## which was isolated from the culture of Streptomyces prunicolor PA-48153 and has biological activity such as immunosuppressive activity, antitumor activity and antifungal activity.Type: GrantFiled: March 12, 1993Date of Patent: May 24, 1994Assignee: Shionogi Seiyaku Kabushiki KaishaInventors: Tadashi Yoshida, Kenzo Koizumi, Yoshimi Kawamura, Koichi Matsumoto, Hiroshi Itazaki
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Patent number: 5284870Abstract: The present invention relates to an aldose reductase inhibitor represented by the formula: ##STR1## wherein R.sub.1 is (CH.sub.2).sub.2 COOH and R.sub.2 is phenyl or p-hydroxyphenyl, or R.sub.1 and R.sub.2 are combined together to form a group of the formula: ##STR2## which was isolated from the fermentation products of Chaetomella circinoseta RF-3192.Type: GrantFiled: February 9, 1993Date of Patent: February 8, 1994Assignee: Shionogi Seiyaku Kabushiki KaishaInventors: Tadashi Yoshida, Toshiyuki Kato, Yoshimi Kawamura, Koichi Matsumoto, Hiroshi Itazaki
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Patent number: 5120647Abstract: A compound of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are --COOR.sup.4, --COOR.sup.5, and --COOR.sup.6, respectively; R.sup.4, R.sup.5, and R.sup.6 each is hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z each is hydrogen or hydroxyl; a dotted line indicates the presence or absence of a single bond; or where W/R.sup.3, X/R.sup.1, and/or Z/R.sup.3 may be combined together, a lactone is formed, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound (I) and a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same are also provided.Type: GrantFiled: November 26, 1990Date of Patent: June 9, 1992Assignee: Shionogi & Co., Ltd.Inventors: Tadashi Yoshida, Hiroshi Itazaki, Hitoshi Arita, Yoshimi Kawamura, Koichi Matsumoto
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Patent number: 5112944Abstract: A cyclic tetrapeptide having the formula (I): ##STR1## wherein n is 4 or 3 and a process for preparing the above cyclic tetrapeptide. The cyclic tetrapeptide of the present invention inhibits transformation of cells caused by oncogenes and possesses activities for recovering to a normal cell and for inhibiting proliferation of carcinoma cells. Therefore, the cyclic tetrapeptide of the present invention is useful for an active ingredient of an antitumor agent.Type: GrantFiled: June 12, 1990Date of Patent: May 12, 1992Assignee: Shionogi & Co., Ltd.Inventors: Kenji Sugita, Hiroshi Itazaki, Koichi Matsumoto, Yoshimi Kawamura
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Patent number: 5099034Abstract: A compound of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are --COOR.sup.4, --COOR.sup.5, and --COOR.sup.6, respectively; R.sup.4, R.sup.5, and R.sup.6 each is hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z each is hydrogen or hydroxyl; a dotted line indicates the presence or absence of a single bond; or where W/R.sup.3, X/R.sup.1, and/or Z/R.sup.3 may be combined together, a lactone is formed, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound (I) and a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same are also provided.Type: GrantFiled: June 27, 1990Date of Patent: March 24, 1992Assignee: Shionogi & Co., Ltd.Inventors: Tadashi Yoshida, Hiroshi Itazaki, Hitoshi Arita, Yoshimi Kawamura, Koichi Matsumoto
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Patent number: 5071749Abstract: Glycopeptide antibiotics PA-45052 which are produced by Nocardia orientalis PA-45052, show potent activity against gram-positive bacteria, especially against methicillin-resistant bacteria, and stimulate growth of animals.Type: GrantFiled: March 25, 1988Date of Patent: December 10, 1991Assignee: Shionogi & Co., Ltd.Inventors: Eiji Kondo, Yoshimi Kawamura, Naoki Tsuji, Koichi Matsumoto, Masaaki Kobayashi, Toshiyuki Kamigauchi, Yoshiyuki Hayashi, Takao Konishi
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Patent number: 5011952Abstract: A compound of the formula: ##STR1## wherein the wave line means .alpha.-bond or .beta.-bond, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound, pharmaceutical composition containing the compound, and a cell culture of a microorganism Thielavia terricola RF-143 producing the compound are also provided.Type: GrantFiled: April 30, 1990Date of Patent: April 30, 1991Assignee: Shionogi & Co., Ltd.Inventors: Tadashi Yoshida, Keizo Inoue, Hitoshi Arita, Shigeru Matsutani, Jun'ichi Shoji, Yoshimi Kawamura
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Patent number: 4946941Abstract: The compounds of the formula: ##STR1## wherein R is ##STR2## or H, wherein X is NH.sub.2 and Y is CH.sub.3 ; or X is OH and Y is H, and their pharmaceutically acceptable salts. The compounds have a potent activity against gram-positive bacteria, especially, methicillin-resistant bacteria.Type: GrantFiled: January 14, 1987Date of Patent: August 7, 1990Assignee: Shionogi & Co., Ltd.Inventors: Eiji Kondo, Naoki Tsuji, Koichi Matsumoto, Yoshimi Kawamura, Tadashi Yoshida, Shinzo Matsuura
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Patent number: 4647693Abstract: Antibiotics DO-248-A and DO-248-B of the following Formula I: ##STR1## wherein R is ethyl or isopropyl, have antibacterial activity against acid-fast bacteria. DO-248-A, DO-248-B, or their pharmaceutically acceptable salts are, as an active ingredient of anti-fast-acid drugs, orally or parenterally administered to human beings or animal. DO-248-A and DO-248-B are prepared by incubating an antibiotic DO-248-A- and/or DO-248-B-producing microorganism belonging to genus Streptoverticillium in a medium and recovering antibiotic DO-248-A and/or DO-248-B from the culture broth.Type: GrantFiled: April 3, 1985Date of Patent: March 3, 1987Assignee: Shionogi & Co., Ltd.Inventors: Eiji Kondo, Yoshimi Kawamura, Takao Konishi, Koichi Matsumoto, Junichi Shoji
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Patent number: 4497797Abstract: .beta.-Galactosidase inhibitors GT-2558, GT-2558-A, and GT-2558-B produced by a strain Streptomyces lydicus PA-5726, and their derivatives, acetyl-GT-2558-A and acetyl-GT-2558-B, useful as diagnostatic aid in .beta.-galactosidase deficiency, used in purification of enzymes, in research of new .beta.-galactosidase, in controlling sweetness of lactose-containing foods and in fermentation industry.Type: GrantFiled: June 29, 1982Date of Patent: February 5, 1985Assignee: Shionogi & Co., Ltd.Inventors: Mitsuo Ebata, Yukio Miyake, Yoshimi Kawamura
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Patent number: 4448723Abstract: New antibiotics having .beta.-lactamase inhibitory activity, PA-41746-B and C of the formula ##STR1## wherein R is carboxymethylsulfinyl (PA-41746-B) or formylsulfinyl (PA-41746-C) and the pharmaceutically acceptable salts being useful as a medicament, a veterinary drug and a disinfectant for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces pluracidomyceticus in a suitable medium and isolating PA-41746-B and/or PA-41746-C from the culture broth.Type: GrantFiled: September 29, 1982Date of Patent: May 15, 1984Assignee: Shionogi & Co., Ltd.Inventors: Kentaro Tanaka, Eiji Kondo, Mikao Mayama, Kouichi Matsumoto, Yoshimi Kawamura, Naoki Tsuji
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Patent number: 4371617Abstract: A new process for preparing thienamycin, a known antibiotic useful as a medicament and veterinary drug, characterized by cultivating Streptomyces penemifaciens sp. nov. in a suitable medium and recovering thienamycin from the fermentation broth.Type: GrantFiled: March 18, 1981Date of Patent: February 1, 1983Assignee: Shionogi & Co., Ltd.Inventors: Kentaro Tanaka, Naoki Tsuji, Eiji Kondo, Yoshimi Kawamura
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Patent number: 4292241Abstract: A new antibiotic having .beta.-lactamase inhibitory activity, PA-31088-IV, being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative phathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces tokunonensis sp. nov. in a suitable medium and recovering PA-31088-IV from the cultured broth.Type: GrantFiled: January 25, 1980Date of Patent: September 29, 1981Assignee: Shionogi & Co., Ltd.Inventors: Kentaro Tanaka, Jun'ichi Shoji, Yoshimi Kawamura, Teruo Hattori, Eiji Kondo, Kouichi Matsumoto, Tadashi Yoshida, Naoki Tsuji
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Patent number: 4256835Abstract: A novel process for preparing cephamycin C known antibiotic being useful as a medicament and veterinary drug, characterized by cultivating Streptomyces todorominensis sp. nov. in a suitable medium and recovering cephamycin C from the fermentation broth.Type: GrantFiled: February 27, 1979Date of Patent: March 17, 1981Assignee: Shionogi & Co., Ltd.Inventors: Yoshimi Kawamura, Jun'ichi Shoji, Kouichi Matsumoto