Abstract: The present invention provides a compound having a structure represented by the general formula (1): (wherein n is 2 to 100; P represents a (C1-C5) alkylene group substituted with one amino group; Q is represented by the following general formula (2): (wherein X represents an oxygen atom, Y1 and Y2 each represent an alkylene group of 1 to 6 carbon atoms, and m is an integer of 1 to 30); and Z represents a click functional group) or a salt thereof and also provides a pharmacological substance which has the compound or a salt thereof attached thereto by a chemical bond and has an improved biomembrane permeability as well as an improved water solubility.

Abstract: The invention provides a promoter derived from a genome of an actinomycete, Streptomyces species, and can specifically induce expression of a transgene in an actinomycete, Streptomyces species, in and after a logarithmic growth phase, and an actinomycete host having a high secondary metabolite production ability and a high precursor supply ability in and after the logarithmic growth phase, and a method for producing useful substances in which the promoter and the actinomycete host are combined.

Abstract: The invention provides a promoter derived from a genome of an actinomycete, Streptomyces species, and can specifically induce expression of a transgene in an actinomycete, Streptomyces species, in and after a logarithmic growth phase, and an actinomycete host having a high secondary metabolite production ability and a high precursor supply ability in and after the logarithmic growth phase, and a method for producing useful substances in which the promoter and the actinomycete host are combined.

Abstract: An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.

Abstract: An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.