Patent number: 6677431
Abstract: An antibacterial &bgr;-peptide having the following formula:
wherein
R1 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl;
R2 is an amine-containing alkyl group having the formula —(CH2)mNH2, wherein m=1, 2, 3, 4, or 5, (CH2)xNHC═NHNH2 wherein x is 1, 2, 3, 4, or 5, a pyridyl, an alkylpryidyl, an amidine-substituted benzyl, a phenyl group, or a cyclic amidine;
R3 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl;
X is —NH2, —OH, —NHR, or OR where R is alkyl, aryl or acyl groups either free or polymer-supported, a carboxamide, a substituted carboxamide, or a polymer;
Y is H, an alkyl group, an acyl group, an acyl-terminated polymer, a sulphonamide, an ether, a urea, a urethane, or a polymer; and
n is 2, 3, 4, 5, 6, or 7.
Type:
Grant
Filed:
December 11, 2000
Date of Patent:
January 13, 2004
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
William F. DeGrado, Yoshimoto Hamuro, Dahui Liu
