Abstract: The present invention provides a method for producing a regenerated T cell population via iPS cells, wherein the said regenerated T cell population maintains the repertoire diversity of a T cell population before initialization and has specificity to an antigen. The method comprises steps of (1) bringing a T cell population into contact with one or more tumor-related antigens, or a biological tissue containing one or more tumor-related antigens, or a crushed material or a lysate thereof, and enriching the T cell population having specificity to the tumor-related antigens, (2) initializing the enriched T cell population to iPS cells, and culturing while maintaining the repertoire diversity of the enriched T cell population, and (3) producing a regenerated T cell population from the cultured iPS cells.

Abstract: [Problem] To provide a method for producing a population of genetically diverse regenerated T cells via iPS cells, and to provide said population of regenerated T cells. [Solution] A method for producing a population of genetically diverse regenerated T cells via iPS cells, including: (1) obtaining a population of T cells that can recognize a target tissue or antigens from a population of the genetically diverse T cells; (2) reprogramming the obtained the population of T cells into iPS cells, culturing the iPS cells while maintaining genetic diversity; and (3) producing a population of the genetically diverse regenerated T cells from the iPS cells.

Abstract: Provided are a new method of producing cells having characteristics of hematopoietic stem/progenitor cells, for use in hematopoietic stem cell transplantation, and hematopoietic stem/progenitor cell-like cells produced by the method. Provided in particular are a method of producing hematopoietic stem/progenitor cell-like cells retaining differentiation pluripotency and self-replication potential, comprising (1) a step for providing a mammalian pro-B cell or progenitor cell thereof, and (2) a step for culturing the cell (1) above under conditions for induction of differentiation into B cells, wherein the function and/or expression of the transcription factor E2A is suppressed at least at the stage of pre-pro-B cells or pro-B cells in the process (2) above; a hematopoietic stem/progenitor cell-like cell produced by the method; and an immunotherapeutic agent comprising the hematopoietic stem/progenitor cell-like cell, and the like.

Abstract: A method for detection of a precursor T cell or precursor B cell, a method for evaluation of the property of a hematopoietic precursor cell in a source for transplantation, and a kit for use in the evaluation are disclosed. A precursor T cell or precursor B cell can be detected by co-cultivating a stromal cell line with a monocyte. By using the detection method, a precursor T cell or precursor B cell can be quantified and can also evaluate the property of a hematopoietic precursor cell in a source for transplantation.

Abstract: [Problem to be solved] In the case where the conventional condom is used, even if it is coated with a lubricant, the surface of the penis as the male organ remains virtually kept in contact with the inside surface of the condom, and the lubricity between them is insufficient. So, since the slip that can occur between them is very slight, the physical stimulation to the penis is limited, and the condom cannot satisfy the sexual desire of the wearer. [Solution] This invention proposes a condom 1 formed of a hydrophobic material, comprising a hydrophilic portion 3 formed on its inside surface on its tip side excluding its base side. The ratio of the length 1 of the hydrophilic portion to the overall length L of the condom excluding the small pocket formed for the semen to get collected at the tip of the condom can be set in a range of 20 to 80%, but if it is set in a range of 25 to 45%, a good balance can be achieved between the enhancement of lubricity and the effect of preventing slipping-off.

Abstract: The present invention provides a method for detection of hematopoietic stem and/or progenitor cells, comprising the steps of culturing individual cells in a culture environment that supports the generation of myeloid, erythroid, T and B lineage cells and determining the developmental potential of individual cells towards these four lineages (MLP<METB> assay), and a method for detection of hematopoietic stem and/or progenitor cells, comprising the steps of culturing individual cells in a culture environment that supports the generation of myeloid, erythroid, and B lineage cells and determining the developmental potential of the individual cells towards these three lineages (MLP<MEB> assay).