Abstract: An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.

Abstract: A controller is provided that is configured to execute: predicting a distribution of first users in a predetermined area; predicting, based on the predicted distribution of the first users, a first point that is a point where a density of the first users exceeds a predetermined upper limit value in the predetermined area in the future; and transmitting, to a terminal of a second user who is a provider of a service, information about prompting provision of the service at a second point other than the first point in the predetermined area.

Abstract: A controller of an information processing apparatus disclosed obtains first information about a tendency of move of a user staying in a specific facility. The controller forecasts, on the basis of the first information, an expected destination of move to which the user will move from the specific facility and an expected time slot of move during which the user will start to move from the specific facility to the expected destination of move. The controller calculates the number of users who are expected to move from the specific facility to the expected destination of move in each expected time slot of move on a slot-by-slot basis.

Abstract: When an information processing apparatus disclosed receives a signal requesting dispatch of a taxi with information about a desired location of getting-in, it determines a recommended location of getting-in on the basis of at least one of information about a physical condition relating to a road in a specific area including the desired location of getting-in, information about instances of users' getting in and/or getting out of taxis that took place in the specific area in the past, and information about a condition of the road in the specific area. The information processing apparatus sends information for inviting a user to wait at the recommended location of getting-in determined as above to a user's terminal used by the user.

Abstract: A controller is provided that is configured to execute: predicting a distribution of first users in a predetermined area; predicting, based on the predicted distribution of the first users, a first point that is a point where a density of the first users exceeds a predetermined upper limit value in the predetermined area in the future; and transmitting, to a terminal of a second user who is a provider of a service, information about prompting provision of the service at a second point other than the first point in the predetermined area.

Abstract: A controller of an information processing apparatus disclosed obtains first information about a tendency of move of a user staying in a specific facility. The controller forecasts, on the basis of the first information, an expected destination of move to which the user will move from the specific facility and an expected time slot of move during which the user will start to move from the specific facility to the expected destination of move. The controller calculates the number of users who are expected to move from the specific facility to the expected destination of move in each expected time slot of move on a slot-by-slot basis.