Abstract: The present disclosure provides a body fluid extract comprising micro RNA.

Abstract: The present disclosure provides a body fluid extract comprising micro RNA.

Abstract: The present disclosure provides a method for extracting a biomolecule. The present disclosure provides a method for extracting a cell-free DNA. The present disclosure provides a method for concentrating a DNA having a non-base pairing base. The present disclosure provides a method for concentrating a DNA having a low methylation modification level.

Abstract: The present disclosure provides a body fluid extract containing micro RNA. According to the present disclosure, an extract of body fluid containing any of the micro RNA described in data S1 or table 2, or in any of tables 4-1 to 4-15, is provided.

Abstract: The present disclosure provides a device for separating biomolecules comprising a substrate having a planar surface, nanowires disposed on at least a portion of the planar surface, and a fluid chamber formed to include at least a portion of the nanowires.

Abstract: Provided are a novel biomarker for a brain tumor and a method for using the same. A method for detecting a brain tumor, the method comprising the step of detecting specific miRNA as biomarker.

Abstract: The present invention provides a novel miRNA extraction method and a method for analyzing miRNA extracted by using said miRNA extraction method. According to the present invention, provided is, for example, a method for extracting miRNA from extracellular vesicles in a sample solution, by using a device capable of capturing extracellular vesicles, the miRNA extraction method comprising: an extracellular vesicle capturing step for capturing extracellular vesicles in a sample solution onto a device by bringing the sample solution and the device in contact with each other; and a miRNA extraction step for homogenizing the extracellular vesicles by bringing the device having captured the extracellular vesicles in contact with a homogenization liquid for extracellular vesicles to extract miRNA from the extracellular vesicle into the homogenization liquid.

Abstract: The present invention provides a novel miRNA extraction method and a method for analyzing miRNA extracted by using said miRNA extraction method. According to the present invention, provided is, for example, a method for extracting miRNA from extracellular vesicles in a sample solution, by using a device capable of capturing extracellular vesicles, the miRNA extraction method comprising: an extracellular vesicle capturing step for capturing extracellular vesicles in a sample solution onto a device by bringing the sample solution and the device in contact with each other; and a miRNA extraction step for homogenizing the extracellular vesicles by bringing the device having captured the extracellular vesicles in contact with a homogenization liquid for extracellular vesicles to extract miRNA from the extracellular vesicle into the homogenization liquid.

Abstract: In a method for analyzing samples involving the use of a device for analyzing samples, the device for analyzing samples includes at least a movement part through which a sample moves, and a measurement unit that is formed in a middle of the movement part and that measures a value of an ion current when the sample passes through the movement part. The analysis method includes at least a measurement step for measuring the value of the ion current when the sample passes through the movement part, and a determination step for determining a change over time in a quantity of ions from the value of the ion current measured in the measurement step. The quantity of ions includes a quantity of ions that have leaked from the sample during movement of the sample through the movement part.

Abstract: A device for biological material detection includes a substrate; a through-hole through which a biological material to be tested passes, the through-hole being formed in the substrate; a molecule that interacts with the biological material to be tested passing through, the molecule being formed in the through-hole; a first chamber member that forms, with at least the surface including the through-hole on one surface side of the substrate, a first chamber to be filled with electrolyte; and a second chamber member that forms, with at least the surface including the through-hole on the other surface side of the substrate, a second chamber to be filled with electrolyte. The biological material to be tested is identified by the waveform of the ion current (passage time, shape, etc.) when the biological material to be tested passes through the through-hole.

Abstract: Provided is a device for electrical measurement designed to be able to perform high sensitivity detection by reading not only changes in steady-state current, but also the occurrence of transient current, and an electrical measurement apparatus including the device for electrical measurement. The device for electrical measurement includes a substrate on which are formed at least a sample separation channel and a sample migration channel, as well as a sample measuring unit, with one end of the sample separation channel formed to connect to one end of the sample migration channel, and the sample measuring unit including a first measuring unit connected to the sample migration channel, and a second measuring unit connected to the sample migration channel from the reverse side to the first measuring unit.

Abstract: The present disclosure provides a body fluid extract comprising micro RNA.

Abstract: The present disclosure provides a device for separating biomolecules comprising a substrate having a planar surface, nanowires disposed on at least a portion of the planar surface, and a fluid chamber formed to include at least a portion of the nanowires.

Abstract: In a method for analyzing samples involving the use of a device for analyzing samples, the device for analyzing samples includes at least a movement part through which a sample moves, and a measurement unit that is formed in a middle of the movement part and that measures a value of an ion current when the sample passes through the movement part. The analysis method includes at least a measurement step for measuring the value of the ion current when the sample passes through the movement part, and a determination step for determining a change over time in a quantity of ions from the value of the ion current measured in the measurement step. The quantity of ions includes a quantity of ions that have leaked from the sample during movement of the sample through the movement part.

Abstract: A toner is provided, where good cleanability is exhibited, abrasion variations of the photo conductor surface is reduced, and contamination of a charge member is reduced. The toner includes toner particles and organic-inorganic composite fine particles on the toner particle surfaces, wherein each of the organic-inorganic composite fine particles is a particle in which inorganic fine particles are exposed at the surfaces of vinyl based resin particles in such a way that convex portions derived from the inorganic fine particles are formed on the surfaces, the average circularity of the toner is 0.960 or more, and the absolute value Q of the amount of triboelectricity of the toner measured by a two-component method and the electrostatic adhesion F of the toner satisfy 0.003?F/Q2?0.040.

Abstract: A device for biological material detection includes a substrate; a through-hole through which a biological material to be tested passes, the through-hole being formed in the substrate; a molecule that interacts with the biological material to be tested passing through, the molecule being formed in the through-hole; a first chamber member that forms, with at least the surface including the through-hole on one surface side of the substrate, a first chamber to be filled with electrolyte; and a second chamber member that forms, with at least the surface including the through-hole on the other surface side of the substrate, a second chamber to be filled with electrolyte. The biological material to be tested is identified by the waveform of the ion current (passage time, shape, etc.) when the biological material to be tested passes through the through-hole.

Abstract: To provide a cell-trapping filter which has a high cell trapping efficiency and which is excellent in water resistance. A cell-trapping filter comprising a substrate and a cell-separating mechanism by size, wherein the substrate has, at least on its surface, a layer formed of a fluorinated polymer having units having a biocompatible group, having a fluorine atom content of from 5 to 60 mass % and having a proportion P represented by the following formula of from 0.

Abstract: Provided is a device for electrical measurement designed to be able to perform high sensitivity detection by reading not only changes in steady-state current, but also the occurrence of transient current, and an electrical measurement apparatus including the device for electrical measurement. The device for electrical measurement includes a substrate on which are formed at least a sample separation channel and a sample migration channel, as well as a sample measuring unit, with one end of the sample separation channel formed to connect to one end of the sample migration channel, and the sample measuring unit including a first measuring unit connected to the sample migration channel, and a second measuring unit connected to the sample migration channel from the reverse side to the first measuring unit.

Abstract: The present invention provides a device capable of detecting a plurality of items in a specimen using a single optical system. Microstructures holding specific binding reagents in a photocured hydrophilic resin are arranged in a channel, whereby the reagents do not mix during manufacture of the device, and a device capable of multiplex detection can be manufactured.

Abstract: A magnetic carrier is provided which can suppress a decrease in glossiness even in a long term use for POD which requires high glossiness. A magnetic carrier includes a filled core particle in which a silicone resin is filled in pores of a porous magnetic core particle and a vinyl resin coating a surface of the filled core particle. In a pore distribution of the porous magnetic core particle measured by a mercury intrusion method, a cumulative pore volume in a pore diameter range of 0.1 to 3.0 ?m is 35.0 to 95.0 mm3/g, and in a pore distribution of the filled core particle measured by a mercury intrusion method, a cumulative pore volume in a pore diameter range of 0.1 to 3.0 ?m is 3.0 to 15.0 mm3/g. The magnetic carrier includes 1.2 to 3.0 parts by mass of the vinyl resin to 100.0 parts by mass of the filled core particle.