Abstract: [Problems] To provide a chemically modified siRNA that has improved stability against RNase enzymes and selectively exhibits silencing of FUS P525L mutation which is a causative gene of ALS. [Solution] Provided is a chemically modified siRNA comprising a sense strand and an antisense strand, or a salt thereof, wherein: the antisense strand includes a complementary or substantially complementary region in a portion of a mRNA that codes FUS P525L mutation protein; the complementary region has a nucleotide length of 19 to 21; and the siRNA contains at least one substitution selected from the group consisting of a 2?-F-nucleotide, a 2?-OMe-nucleotide, a nucleotide in which a 2?-O atom and a 4?-O atom are bridged by methylene, a 2?-deoxynucleotide, and a phosphorothioate bond that forms an internucleotide bond.

Abstract: An eyewear lens according to the present invention is configured so as to be provided with: a transparent first substrate having a principal surface; a second substrate disposed facing the principal surface, the transmittance thereof with respect to light in a predetermined wavelength region being different from that of the first substrate; an electric element in which optical characteristics thereof is changed by electrical control, the electric element being provided between the first substrate and the second substrate; and an adhesive layer provided between the first substrate and the second substrate.

Abstract: This lens is provided with: a transparent first substrate; a transparent second substrate provided facing the first substrate in the thickness direction of the first substrate; a first optical characteristic varying portion which is provided between the first substrate and the second substrate, and which has an optical characteristic which is varied by means of electric control; and a second optical characteristic varying portion which is provided between the first substrate and the second substrate, is provided displaced with respect to the first optical characteristic varying portion in the thickness direction, and which has a optical characteristic which is varied by means of electric control.

Abstract: A lens includes: a substrate that includes a diffraction region where a plurality of protruding strips are coaxially and alternately formed. The diffraction region includes a first diffraction region and a second diffraction region that is located in at least a part of a region different from the first diffraction region. The second diffraction region includes: groove spaces lying between adjacent ones of the protruding strips with one another; and a communication space communicating between adjacent ones of the groove spaces with one another.

Abstract: This lens is provided with: a transparent first substrate; a transparent second substrate provided facing the first substrate in the thickness direction of the first substrate; a first optical characteristic varying portion which is provided between the first substrate and the second substrate, and which has an optical characteristic which is varied by means of electric control; and a second optical characteristic varying portion which is provided between the first substrate and the second substrate, is provided displaced with respect to the first optical characteristic varying portion in the thickness direction, and which has a optical characteristic which is varied by means of electric control.

Abstract: A drive recorder includes: an image acquisition interface that acquires image data captured by a camera mounted to a vehicle; an imaging controller that causes the camera to capture a first image, in which a first imaging condition is used, and a second image, in which a second imaging condition is used, in temporally different frames; an image recorder that records moving image data based on the first image; a passenger detector that detects a passenger in the vehicle; an image processor that generates, based on the second image including the passenger detected by the passenger detector, a passenger image in which visibility of an image portion including the passenger is higher than in the second image; and a display controller that causes the display device to display moving images based on the passenger image.

Abstract: This eyewear comprises: a frame; an input unit which is disposed in the frame and accepts a first instruction operation and a second instruction operation that are different from each other; an optical module which is held in the frame and has an optical characteristic that changes by electric control; and a control unit which changes the optical characteristic of the optical module by selectively executing an upper-class function by the first instruction operation, and selectively executing a lower-class function by the second instruction operation. Consequently, the eyewear enabling execution of a larger number of functions with a simpler manipulation can be provided.

Abstract: A lens includes: a substrate that includes a diffraction region where a plurality of protruding strips are coaxially and alternately formed. The diffraction region includes a first diffraction region and a second diffraction region that is located in at least a part of a region different from the first diffraction region. The second diffraction region includes: groove spaces lying between adjacent ones of the protruding strips with one another; and a communication space communicating between adjacent ones of the groove spaces with one another.

Abstract: This eyewear system is provided with a first lens including an optical characteristic variation region in which an optical characteristic varies, a first frame for retaining the first lens, and a second frame for retaining a second lens different from the first lens, the first frame having a first attachment part for attaching the first frame to the second frame, or the second frame having a second attachment part for attaching the second frame to the first frame, so that the first lens and the second lens face each other and the optical characteristic variation region is positioned in the field of view of a subject through the second lens.

Abstract: An eyewear lens according to the present invention is configured so as to be provided with: a transparent first substrate having a principal surface; a second substrate disposed facing the principal surface, the transmittance thereof with respect to light in a predetermined wavelength region being different from that of the first substrate; an electric element in which optical characteristics thereof is changed by electrical control, the electric element being provided between the first substrate and the second substrate; and an adhesive layer provided between the first substrate and the second substrate.

Abstract: A drive recorder includes: an image acquisition interface that acquires image data captured by a camera mounted to a vehicle; an imaging controller that causes the camera to capture a first image, in which a first imaging condition is used, and a second image, in which a second imaging condition is used, in temporally different frames; an image recorder that records moving image data based on the first image; a passenger detector that detects a passenger in the vehicle; an image processor that generates, based on the second image including the passenger detected by the passenger detector, a passenger image in which visibility of an image portion including the passenger is higher than in the second image; and a display controller that causes the display device to display moving images based on the passenger image.

Abstract: The lens comprises: a first transparent substrate that includes a diffraction region in which a plurality of convex strips and groove sections are formed in alternation in concentric circles; a second transparent substrate that faces the first transparent substrate; a liquid crystal layer disposed in a space present between the diffraction region and the second transparent substrate; and a first transparent electrode and a second transparent electrode that impress a voltage on the liquid crystal layer. The diffraction region comprises a first diffraction region and a second diffraction region that is disposed in at least part of a portion different from the first diffraction region. The space comprises: groove-shaped spaces present between the groove sections and the second transparent substrate; and a communicating space disposed between at least part of the convex shapes of the second diffraction region and the second transparent substrate, and communicating between neighboring groove-shaped spaces.

Abstract: Eyewear having: a frame; an optical module held by the frame and changing optical properties by electric control; a sensing unit that obtains information pertaining to a usage environment; and a control unit that, on the basis of the information obtained by the sensing unit, changes the optical properties of the optical module. The control unit switches between a mode in which optical properties of can be changed and a mode in which optical properties cannot be changed, on the basis of the information obtained by the sensing unit, and changes the optical properties of the optical module when in the mode in which optical properties can be changed. As a result, eyewear is provided that can switch between modes that change or do not change optical properties, in accordance with the usage environment.

Abstract: A lens is provided with a lens body. The lens body is provided with a Fresnel lens part in which a plurality of protrusions and depressions that constitute at least parts of a plurality of concentric circles are formed. A diffracting part has a horizontally elongated outer shape when viewed in a direction in which light enters the lens body, and at least parts of first outer peripheral edges of the diffracting part located at both ends in a longitudinal direction form circular arcs that extend along concentric circles. Second outer peripheral edges of the diffracting part that are located at both ends in a lateral direction are located inward from a concentric circle that includes circular arcs formed by parts of the first outer peripheral edges, and are connected to parts of the first outer peripheral edges forming the circular arcs via bent portion.

Abstract: The lens comprises: a first transparent substrate that includes a diffraction region in which a plurality of convex strips and groove sections are formed in alternation in concentric circles; a second transparent substrate that faces the first transparent substrate; a liquid crystal layer disposed in a space present between the diffraction region and the second transparent substrate; and a first transparent electrode and a second transparent electrode that impress a voltage on the liquid crystal layer. The diffraction region comprises a first diffraction region and a second diffraction region that is disposed in at least part of a portion different from the first diffraction region. The space comprises: groove-shaped spaces present between the groove sections and the second transparent substrate; and a communicating space disposed between at least part of the convex shapes of the second diffraction region and the second transparent substrate, and communicating between neighboring groove-shaped spaces.

Abstract: A polarized electromagnetic relay having a pair of first and second pole members which are magnetized to opposite polarity by a permanent magnet coupled thereto and which define therebetween a magnetic gap into which the other end of the armature extends. The first pole member and the armature are magnetically coupled to the base so as to cause a magnet flux of the permanent magnet to circulate through the second pole member, the armature, the base, and the first pole member for attracting the armature to the second pole member. Upon energization of the coil, a resulting coil flux circulates through the armature, the base, and the first pole member in opposing direction to the magnet flux for attracting the armature to the first pole member. A cover and base of magnetic material is included to fit over the base and be magnetically coupled thereto.

Abstract: A substrate for a magnetic disc prepared from an aluminum alloy which consists essentially of from 3.0 to 5.0 percent, preferably from 3.5 to 4.5 percent, Mg, from 0.5 to 3.0 percent, preferably from 0.5 to 1.7 percent, Zn, and the balance Al and inevitable impurities. The inevitable impurities contain not more than 0.10 percent Si, not more than 0.10 percent Fe, not more than 0.01 percent, Mn, not more than 0.01 percent Cr, not more than 0.01 percent Ni, and not more than 0.01 percent Ti.The aluminum alloy substrate may also contain from 0.3 to 2.0 percent, preferably from 0.5 to 1.0 percent, Cu, and/or from 0.02 to 0.5 percent, preferably from 0.05 to 0.2 percent, Zr.

Abstract: An improved magnetic actuator mechanism suitable for dot printing mechanisms for use in a wire matrix dot printer. The present magnetic actuator mechanism comprises an armature movable between a reset position and an actuated position, a permanent magnet for attracting the armature toward the reset position, and an electromagnet which, when energized, generates in the armature a magnetic flux opposite to and larger than the magnetic flux generated therein by the permanent magnet. The armature is thus moved to the actuated position by the turn of the magnetization direction in the armature when the electromagnet is energized.