Patents by Inventor Yoshinobu Yoshimura
Yoshinobu Yoshimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11267797Abstract: The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 22, 2020Date of Patent: March 8, 2022Assignees: Kyoto Pharmaceutical Industries, Ltd., Sumitomo Dainippon Pharma Co., Ltd.Inventors: Yoshinobu Yoshimura, Masayasu Kasai, Yoshimichi Shoji, Shigemitsu Takeda
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Publication number: 20200317630Abstract: The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 22, 2020Publication date: October 8, 2020Applicants: Kyoto Pharmaceutical Industries, Ltd., Sumitomo Dainippon Pharma Co., Ltd.Inventors: Yoshinobu YOSHIMURA, Masayasu KASAI, Yoshimichi SHOJI, Shigemitsu TAKEDA
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Patent number: 10689355Abstract: The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 27, 2019Date of Patent: June 23, 2020Assignees: Kyoto Pharmaceuticals Industries, Ltd., Sumitomo Dainippon Pharma Co., Ltd.Inventors: Yoshinobu Yoshimura, Masayasu Kasai, Yoshimichi Shoji, Shigemitsu Takeda
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Publication number: 20190322636Abstract: The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 27, 2019Publication date: October 24, 2019Applicants: Kyoto Pharmaceutical Industries, Ltd., Sumitomo Dainippon Pharma Co., Ltd.Inventors: Yoshinobu YOSHIMURA, Masayasu KASAI, Yoshimichi SHOJI, Shigemitsu TAKEDA
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Patent number: 10377730Abstract: The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 23, 2018Date of Patent: August 13, 2019Assignees: Kyoto Pharmaceutical Industries, Ltd., Sumitomo Dainippon Pharma Co., Ltd.Inventors: Yoshinobu Yoshimura, Masayasu Kasai, Yoshimichi Shoji, Shigemitsu Takeda
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Publication number: 20180265489Abstract: The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: May 23, 2018Publication date: September 20, 2018Applicants: Kyoto Pharmaceutical Industries, Ltd., Sumitomo Dainippon Pharma Co., Ltd.Inventors: Yoshinobu YOSHIMURA, Masayasu KASAI, Yoshimichi SHOJI, Shigemitsu TAKEDA
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Patent number: 10005752Abstract: The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 9, 2015Date of Patent: June 26, 2018Assignees: Kyoto Pharmaceutical Industries, Ltd., Sumitomo Dainippon Pharma Co., Ltd.Inventors: Yoshinobu Yoshimura, Masayasu Kasai, Yoshimichi Shoji, Shigemitsu Takeda
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Publication number: 20170121299Abstract: The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 9, 2015Publication date: May 4, 2017Applicant: KYOTO PHARMACEUTICAL INDUSTRIES, LTD.Inventors: Yoshinobu YOSHIMURA, Masayasu KASAI, Yoshimichi SHOJI, Shigemitsu TAKEDA
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Patent number: 5449902Abstract: An apparatus for directly connecting an analytical column and a mass spectrometer comprising a fixed member having at least four holes which respectively introduce washing solution, eluate containing a component eluted from the analytical column, desalting solution and eluent for eluting the component, and a movable member rotated with respect to an axis having at least four tubes around the axis and mounting the four trapping columns, whereby the trapping columns are respectively washed, trapped, desalted and eluted in parallel. Furthermore, a common trapping column may be used instead of the four trapping columns by controlling the apparatus with four analytical modes.Type: GrantFiled: December 16, 1993Date of Patent: September 12, 1995Assignees: Hitachi, Ltd., Takeda Chemical Industries, Ltd.Inventors: Kouzi Onishi, Norio Tada, Yoshinobu Yoshimura, Yoshiaki Kato
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Patent number: 5120841Abstract: A compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group; R.sub.2 is an unsubstituted or lower alkyl-substituted alicyclic alkyl group of 3 to 12 carbon atoms or a C.sub.3-6 alicyclic alkyl-substituted lower alkyl group or a pharmaceutically acceptable salt thereof, processes for preparing the same, a pharmaceutical composition thereof are provided. The compound has an improved absorbability and can be orally applied as antibiotics.Type: GrantFiled: March 18, 1987Date of Patent: June 9, 1992Assignee: Takeda Chemical Industries, Ltd.Inventors: Tatsuo Nishimura, Yoshinobu Yoshimura, Mitsuo Numata
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Patent number: 4921851Abstract: This invention relates to a compound of the formula: ##STR1## wherein Q is nitrogen or CH; R.sup.1 is hydrogen or a lower alkyl group which may be substituted; and ring A is a pyridine or pyridazine ring which is substituted at the ring-constituting carbon atom by a group of the formula:--E--(CH.sub.2).sub.n --R.sup.2in which E is sulfur or NH; R.sup.2 is an amino, carbamoylamino, formylamino, acetylamino, N-formimidoylamino, N-acetimidoylamino, lower alkylamino, hydroxyl or carbamoyloxy group; and n is an integer of 2 to 4, or a pharmaceutically acceptable salt thereof. The compound (I) or a pharmaceutically acceptable sale thereof has excellent antibacterial activity and is used as antibiotics.Type: GrantFiled: August 22, 1989Date of Patent: May 1, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Shoji Kishimoto, Kiminori Tomimatsu, Akio Miyake, Yoshinobu Yoshimura
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Patent number: 4839351Abstract: A compound of the general formula: ##STR1## wherein R.sup.0 is hydrogen, a nitrogen-containing heterocyclic group, an acyl group or an amino-protective group; A is S, S.fwdarw.O, O or CH.sub.2 ; R.sup.4 is hydrogen, methoxy group or formamido group; R.sup.13 is hydrogen, methyl, hydroxyl or a halogen; and A is an optionally substituted condensed cyclic group formed by combining an imidazole or pyrazole ring with 5- or 6-membered nitrogen-containing aromatic heterocyclic ring to share a C-N bond with each other,or a salt or ester thereof.and a process for preparing the same and a pharmaceutical composition thereof are disclosed.Type: GrantFiled: December 12, 1986Date of Patent: June 13, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Tatsuo Nishimura, Yoshinobu Yoshimura, Akio Miyake, Naoto Hashimoto
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Patent number: 4826834Abstract: A compound having the general formula ##STR1## wherein, R.sup.0 is a hydrogen atom, a nitrogen-containing heterocyclic group, an acyl group or an amino-protective group; Z is S, S.fwdarw.O,O or CH.sub.2 ; R.sup.4 is a hydrogen atom, a methoxy group, or a formamide group; R.sup.13 is a hydrogen atom, a methyl group, a hydroxyl group, or a halogen atom; A.sym. is a condensed triazolio group which may be substituted, or a pharmaceutically acceptable salt or ester thereof is novel and has an excellent antibacterial activity.Type: GrantFiled: September 22, 1986Date of Patent: May 2, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshinobu Yoshimura, Naoto Hashimoto, Shoji Kishimoto
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Patent number: 4797395Abstract: A compound of the formula ##STR1## wherein (1) R.sub.1 is a lower alkyl group of 2 to 6 carbon atoms or a cycloalkyl group of 5 to 7 carbon atoms and R.sub.2 is a cycloalkyl group of 5 to 7 carbon atoms or a lower alkyl group of 1 to 3 carbon atoms which is substituted by a cycloalkyl group of 5 to 7 carbon atoms or by a phenyl group, or (2) R.sub.1 is a cycloalkyl group of 5 to 7 carbon atoms and R.sub.2 is a lower alkyl group of 1 to 5 carbon atoms, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a pharmaceutical composition thereof are provided. The compound can orally be applied as antibiotics having improved bioavailability.Type: GrantFiled: July 18, 1986Date of Patent: January 10, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Akio Miyake, Yoshinobu Yoshimura, Mitsuo Numata
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Patent number: 4729992Abstract: A compound of the formula: ##STR1## or a pharmaceutical acceptable salt thereof, processes for preparing the same and a pharmaceutical composition containing the compound or the salt thereof mentioned above are provided. The compound has antibiotic activity and has improved absorbability.Type: GrantFiled: April 19, 1985Date of Patent: March 8, 1988Assignee: Tatsuo Chemical Ind., Ltd.Inventors: Tatsuo Nishimura, Yoshinobu Yoshimura, Mitsuo Numata
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Patent number: 4609650Abstract: A novel steroid compound of the formula ##STR1## wherein A is a lower alkylene group; ##STR2## is an acyl group; and is a single bond or a double bond, and methods of producing the compound (I) as follows: ##STR3## and a pharmaceutical composition containing the compound (I). The compound (I) exhibits excellent antiandrogenic activity on oral administration and can be used for the treatment of prostatic hypertrophy.Type: GrantFiled: March 27, 1984Date of Patent: September 2, 1986Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshinobu Yoshimura, Yoko Nishida, Takatsuka Yashiki
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Patent number: 4497809Abstract: Cephalosporin derivatives of the formula: ##STR1## wherein R.sub.1 is methyl or ethyl and R.sub.2 is a straight-chain or branched alkyl group of 5 to 7 carbon atoms, and their pharmaceutically acceptable salts, which are effective as orally administrable antibiotic agents against both gram-positive- and negative-bacteria, and the production and compositions thereof, are proposed.Type: GrantFiled: April 20, 1983Date of Patent: February 5, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshinobu Yoshimura, Naoru Hamaguchi, Takatsuka Yashiki
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Patent number: 4316018Abstract: Crystallized cephalosporin salts, particularly crystalline addition salt of pivaloyloxymethyl 7.beta.-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1 H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylate with hydrochloric acid, tartaric acid or citric acid, which is very stable and is readily adsorbable through intestinal tract, with little individual differences, when the salt is applied orally.Type: GrantFiled: May 6, 1980Date of Patent: February 16, 1982Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshinobu Yoshimura, Nobuhide Morikawa, Kunio Takanohashi
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Patent number: 4260607Abstract: A cephalosporin derivative of the formula: ##STR1## wherein R represents ##STR2## or its pharmaceutically acceptable acid addition salt is found to be useful as orally administrable antibiotics having broad anti-microbial activities against both Gram-positive and Gram-negative bacteria.Type: GrantFiled: September 18, 1979Date of Patent: April 7, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Nobuharu Kakeya, Yoshinobu Yoshimura
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Patent number: 4189479Abstract: Novel cephalosporin derivatives, namely pivaloyloxymethyl 7.beta.-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1 H-tetrazol-5-yl]thio]methyl]-ceph-3-em-4-carboxylate and its pharmaceutically acceptable acid addition salts are found to be useful as orally administrable antibiotics having broad antimicrobial activities against both gram-positive and gram-negative bacteria.Type: GrantFiled: December 22, 1977Date of Patent: February 19, 1980Assignee: Takeda Chemical Industries, Ltd.Inventors: Nobuharu Kakeya, Yoshinobu Yoshimura