Abstract: An object of the present invention is to provide a novel agent capable of activating SIRT6. A sirtuin 6 activator containing a urolithin as an active ingredient.

Abstract: The object of the present invention is to provide an inexpensive and effective sirtuin activator derived from natural products. The problem can be solved by a sirtuin activator comprising ?-alanine or a salt thereof, or a composition for activating sirtuin comprising the sirtuin activator as an active ingredient, of the present invention.

Abstract: An object of the present disclosure is at least to provide a technique for enhancing expression of a NAMPT gene. The object is achieved by a composition for enhancing NAMPT gene expression, the composition containing an equol compound as an active ingredient.

Abstract: The object of the present invention is to provide a pharmaceutical agent which activate mitochondrial function, particularly, an inexpensive pharmaceutical agent. The problem can be solved by a mitochondrial function activator of the present invention, comprising ?-alanine or glycine, or a salt thereof.

Abstract: A disease risk assessment apparatus (100) includes an assessment unit (1) for assessing the risk of developing dementia in a subject, based on the concentration of an amino acid in the blood of the subject. The amino acid includes at least one selected from the group consisting of histidine, phenylalanine, leucine, isoleucine, methionine, threonine, glycine, glutamine, lysine, asparagine, homocysteine, cystathionine, S-adenosylmethionine, and S-adenosylhomocysteine.

Abstract: An agent uses at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for improving a neuropsychologic function, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for changing expression of a transporter such as SLC23A2, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof, and an agent for controlling blood concentration of a cytokine such as IP-10, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof, as well as an expression analysis method for detecting improvement or degradation of a neuropsychologic function, and a kit for detecting improvement or degradation of a neuropsychologic function.

Abstract: Disclosed are a method for potentiating a sirtuin gene in a living body, provided to the living body as a pharmaceutical product, a cosmetic product, or a food product including a sirtuin gene potentiator. The sirtuin gene potentiator of the present invention contains a given polyphenol and/or terpenoid as an active component. The polyphenol and/or the terpenoid can be contained in the form of a plant such as pomegranate or a plant extract thereof. The sirtuin gene potentiator of the present invention is available from a familiar material to avoid concerns such as side effects on the human body in advance. Such a sirtuin gene potentiator is useful as a novel material in the fields of pharmaceutical products, cosmetic products, and food products.

Abstract: An anti-aging agent derived from a natural product is provided. The agent uses at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for improving a neuropsychologic function, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient.

Abstract: Disclosed are a sirtuin gene potentiator, and a pharmaceutical product, a cosmetic product, and a food product using the same. The sirtuin gene potentiator of the present invention contains a given polyphenol and/or terpenoid as an active component. The polyphenol and/or the terpenoid can be contained in the form of a plant such as pomegranate or a plant extract thereof. The sirtuin gene potentiator of the present invention is available from a familiar material to avoid concerns such as side effects on the human body in advance. Such a sirtuin gene potentiator is useful as a novel material in the fields of pharmaceutical products, cosmetic products, and food products.