Abstract: A family of platinum complexes which are stable and exhibit anticancer activity.

Abstract: A platinum(IV) complex represented by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 independently represent ammonia, an alkylamine or a cycloalkylamine, or R.sub.1 and R.sub.2 may together form a cycloalkyldiamine; X.sub.1 and X.sub.2 independently represent a halogen, nitrate ion, sulfate ion or a monocarboxylic acid, or X.sub.1 and X.sub.2 may together form a glycolate or a dicarboxylic acid; Y.sub.1 represents formic acid, a C.sub.1 -C.sub.8 alkyl-, alkenyl-, aryl-, aralkyl-, alkylamino- or alkoxyl-monocarboxylic acid or sulfonic acid; and Y.sub.2 represents a halogen. The complex of the invention is stable even when orally administered and has high antitumor activity.

Abstract: Disclosed is an anti-tumor liposoluble platinum (IV) complexes having Formula I, a Formula VI or a Formula XII. Because these complexes have liposoluble groups, they are effective for various internal organ tumors or cancers.

Abstract: Novel platinum(II)-steroid complexes are now provided, which exhibit antitumor activities as shown by tests on mouse leukemia, L-1210 cells in mice. These novel platinum(II)-steroid complexes contain a 1,2-cyclohexanediamine, a 2-(aminomethyl)cyclohexylamine, an ethylenediamine or NH.sub.3 --groups as a ligand or ligands.

Abstract: New platinum (IV) complexes are now provided, which exhibit antitumor activity as shown by the tests on mouse leukemia, L-1210 cell in mice. These new platinum (IV) complexes contain 1,2-cyclohexanediamine or 2-(aminomethyl)cyclohexyl-amine as a ligand.

Abstract: New platinum(II)-flavin complexes are now provided, which exhibit antitumor activities as shown by tests on mouse leukemia, L-1210 cells in mice. These novel platinum(II)-flavin complexes contain a 1,2-cyclohexanediamine, a 2-(aminomethyl)cyclohexylamine, an ethylenediamine or NH.sub.3 -- groups as a ligand or ligands.

Abstract: 1,2-Diaminocyclohexane platinum (II) complexes of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, are selected from nitrate and various organic carboxylate groups, with the proviso that R.sub.1 and R.sub.2 are not both nitrate, and the configuration of the 1,2-diaminocyclohexane being selected from cis, trans-d and trans-1, have been found to exhibit potent cytostatic activity.They may be made by reacting a starting material, in which R.sub.1 and R.sub.2 are nitrate, with the appropriate carboxylic acid or salt thereof.

Abstract: Disclosed herein are novel complex compounds of platinum showing an antitumor activity, represented by the formula(I): ##STR1## wherein one of R.sup.1 and R.sup.2 represents a group selected from the group consisting of (1) glucuronato groups whose hydroxyl groups may be acylated, (2) gluconato groups whose hydroxyl groups may be acylated, (3) pyruvato group and (4) nitrato group, and the other of R.sup.1 and R.sup.2 represents a group selected from the group consisting of (i) glucuronato groups whose hydroxyl groups may be acylated, (ii) gluconato groups whose hydroxyl groups may be acylated, (iii) pyruvato group and (iv) halogen atoms, or R.sup.1 and R.sup.

Abstract: The invention relates to compounds that are complexes of diaminocyclohexane platinum glucuronic acid halide and the use of these compounds as anti-tumor agents for lower animals.

Abstract: Platinum(II) complexes comprising platinum(II), a diamine, a ligand of D-gluconic acid and an inorganic or organic anion or ligand, and effecting superior antineoplastic activity at a smaller dose.

Abstract: Cis-platinum (II) complexes wherein platinum (II) coordinates 1,2-diamino-cyclohexane (cis-, trans-l-or trans-d-) are disclosed. The complexes exhibit anti-tumor activity.

Abstract: New platinum complex represented by the general formula [I]: ##STR1## wherein R.sub.1 and R.sub.2 are same and represent halogen atom or NO.sub.3,orR.sub.1 is SO.sub.4 and R.sub.2 is H.sub.2 O,orR.sub.1 and R.sub.2 are bonded with each other to form either ##STR2## and the configuration of 1-aminomethyl-2-aminocyclohexane is selected from trans-1, trans-d, cis-1 and cis-d.The compounds of the formula [I] are active against tumor and are expected to be useful as medicaments.

Abstract: Cis-platinum (II) complexes wherein platinum (II) coordinates 1,2-diamino-cyclohexane (cis-, trans-l- or trans-d-) are disclosed. The complexes exhibit anti-tumor activity.

Abstract: Cis-platinum (II) complexes of 1,2-diaminocyclohexanes, more particularly, cis-platinum (II) complexes represented by the general formula ##STR1## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans-d- or trans-l-; and R.sup.1 and R.sup.2, which are same, each represent a halogen atom, or R.sup.1 and R.sup.2, when taken together, represent a group represented by the formula ##STR2## wherein R.sup.3 represents a >CH.sub.2 group, a >CHCH.sub.3 or >CHCH.sub.2 CH.sub.3 group are disclosed. Further complexes of uracil and cis-[platinum(II)-cis-, trans-d or trans-l- 1,2-diaminocyclohexane] are disclosed. These complexes have anti-tumor activity in mice. Cis-platinum (II) complex of cis-1,2-diaminocyclohexane is most effective.