Abstract: The present invention is directed to drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-activated calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-activated calcium channel inhibitors containing the above compounds as the active ingredient, wherein each substituent is defined in the specification. The present invention also relates to a pharmaceutical composition containiing an effective amount of the compound of formula (I) and a pharmaceutically effective carrier. The present invention further relates to methods of treatment of diseases associated with calcium release-activated calcium channels, diseases associated with IL-2 production, and methods of treatment of allergic, inflammatory or auto-immune diseases.

Abstract: A vechicle body structure for an automotive vehicle comprising front side frames (21, 21) provided left and right at a front portion of a vehicle body (10) so as to hold a longitudinal center line of the vehicle body therebetween, rear side frames (26, 26) provided left and right at a rear portion of the vehicle body so as to hold the longitudinal center line of the vehicle body therebetween and side sills (23, 23) or floor frames (27, 27) provided left and right so as to hold the longitudinal center line of the vehicle body therebetween and lower than the front side frames and rear side frames when viewed from the side of the vehicle body, the front side frames, rear side frames and side sills or floor frames being connected to each other, and further a floor tunnel having the bottom-open U-shaped cross-sectional structure which extends along the longitudinal center line of the vehicle body between said front side frames and said rear side frames and protrudes upwardly of the side sills (23, 23) or floor fra

Abstract: Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors containing the above compounds as the active ingredient, 1

Abstract: Quinuclidine derivatives represented by general following general formula (I), salts, N-oxides or quaternary ammonium salts thereof, and medicinal compositions containing the same. The compound has an antagonistic effect on muscarinic M3 receptors and is useful as a preventive or remedy for urologic diseases, respiratory diseases or digestive diseases.

Abstract: Quinuclidine derivatives represented by general following general formula (I), salts, N-oxides or quaternary ammonium salts thereof, and medicinal compositions containing the same. ##STR1## The compound has an antagonistic effect on muscarinic M.sub.3 receptors and is useful as a preventive or remedy for urologic diseases, respiratory diseases or digestive diseases.

Abstract: 1,8-Naphthyridine derivatives represented by the following general formula (I), salts thereof, hydrates thereof and solvates thereof. ##STR1## They have an activity to inhibit type IV phosphodiesterase and are useful as agents for the prevention and treatment of respiratory diseases, inflammatory diseases accompanying organ transplantation, systemic or local arthropathy, proliferative diseases, micturition-related diseases and diseases in which tumor necrosis factor (TNF) and other cytokine (IL-1, IL-6 or the like) are concerned.

Abstract: This invention relates to novel benzodiazepine derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, ##STR1## (wherein R.sup.1 is an aryl group, or an aromatic heterocyclic radical of 5-membered monocyclic, 6-membered monocyclic or 5- and 6-membered bicyclic structure, which may optionally be substituted; and R.sup.2 is an aryl group which may optionally be substituted), to medicinal compositions comprising the same, and to a process for producing the same. The compounds of formula (I) shown above exhibit antagonism for the CCK-B receptor and the action of depressing the gastric acid secretion caused by the stimulus of pentagastrin, and are therefore useful as a drug for the relief of diseases related to the CCK-B receptor and the gastrin receptor.

Abstract: An engine starting device for starting an engine by connecting an output member on the side of a spiral spring and an input member on the side of the engine with each other when the force accumulation by the spring is released. A driving member is driven by the output of the engine. An automatic force accumulating operation for the spiral spring is driven by the driving member. A one-way clutch mechanism connects the automatic force accumulating operation means in a winding pressure accumulating mechanism for the spiral spring with each other.

Abstract: An engine starting device for starting an engine by connecting an output member on the side of a spiral spring and an input member on the side of the engine with each other when the force accumulation by the spring is released. A driving member is driven by the output of the engine. An automatic force accumulating operation mechanism for the spiral spring is driven by the driving member. A one-way clutch connects the automatic force accumulating operation mechanism in a winding pressure accumulating mechanism for the spiral spring with each other.

Abstract: An engine oil level detection device of a construction, wherein an observation window is provided in one part of an oil receptacle or pan, and a wiper to clean the inner surface of the window soiled with the lubricant oil stuck thereonto by splashing is held on the window portion in a manner to be rotatable by finger actions or by a tool.

Abstract: Reaction moment, acting upon the crankcase of a conventional engine when the crankshaft is accelerated or decelerated, is minimized by the provision of a balance shaft carrying a weighted mass and arranged in parallel with the crankshaft and transmission means including a pair of intermeshing gears of an appropriate gear ratio mounted on the two parallel shafts. One of the gears in mesh is divided in two gear sections which is resiliently connected to the associated shaft normally to have an appropriate amount of phase shift therebetween to eliminate backlash.