Patents by Inventor Yoshinori Yamano
Yoshinori Yamano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9085611Abstract: Provided are a humanized monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient, as an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Concretely, the humanized monoclonal antibody of the present invention has an excellent inhibitory activity on the cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the humanized monoclonal antibody of the present invention has a high affinity for PcrV.Type: GrantFiled: January 4, 2013Date of Patent: July 21, 2015Assignee: SHIONOGI & CO., LTD.Inventors: Yoshinori Yamano, Yoshito Numata, Takafumi Sato, Toshinaga Tsuji, Keiko Kawamoto
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Patent number: 8778874Abstract: Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and RA represents, e.g., the formula —X1—Ar1—X2—Y—X3—Ar2 (wherein X1, X2, and X3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N?, ?N—, —NR1—, —O—, etc.; Y represents —NR2CO— or —CONR2— (wherein R2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.Type: GrantFiled: November 24, 2005Date of Patent: July 15, 2014Assignees: National University Corporation Nagoya University, Shionogi & Co., Ltd.Inventors: Hirokazu Arimoto, Jun Lu, Yoshinori Yamano, Tatsuro Yasukata, Osamu Yoshida, Tsutomu Iwaki, Yutaka Yoshida, Issei Kato, Kenji Morimoto, Kayo Yasoshima
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Patent number: 8501179Abstract: Provided is an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Provided are a monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient. Concretely, monoclonal antibody of the present invention has excellent inhibiting activity on cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the monoclonal antibody of the present invention has high affinity with PcrV.Type: GrantFiled: January 8, 2009Date of Patent: August 6, 2013Assignee: Shionogi & Co., Ltd.Inventors: Yoshito Numata, Yoshinori Yamano, Takafumi Sato, Toshinaga Tsuji
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Publication number: 20120093808Abstract: Provided are a humanized monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient, as an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Concretely, the humanized monoclonal antibody of the present invention has an excellent inhibitory activity on the cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the humanized monoclonal antibody of the present invention has a high affinity for PcrV.Type: ApplicationFiled: March 9, 2010Publication date: April 19, 2012Applicant: Shionogi & Co., Ltd.Inventors: Yoshinori Yamano, Yoshito Numata, Takafumi Sato, Toshinaga Tsuji, Keiko Kawamoto
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Publication number: 20110150896Abstract: Provided is an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Provided are a monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient. Concretely, monoclonal antibody of the present invention has excellent inhibiting activity on cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the monoclonal antibody of the present invention has high affinity with PcrV.Type: ApplicationFiled: January 8, 2009Publication date: June 23, 2011Applicant: Shionogi & Co., Ltd.Inventors: Yoshito Numata, Yoshinori Yamano, Takafumi Sato, Toshinaga Tsuji
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Patent number: 7696354Abstract: A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: April 9, 2008Date of Patent: April 13, 2010Assignee: Shionogi & Co., Ltd.Inventors: Yasuhiro Nishitani, Yoshinori Yamano
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Publication number: 20090131655Abstract: A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene) Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.Type: ApplicationFiled: April 9, 2008Publication date: May 21, 2009Inventors: Yasuhiro Nishitani, Yoshinori Yamano
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Patent number: 7384928Abstract: A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: March 18, 2003Date of Patent: June 10, 2008Assignee: Shionogi & Co., Ltd.Inventors: Yasuhiro Nishitani, Yoshinori Yamano
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Publication number: 20080097078Abstract: Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and RA represents, e.g., the formula —X1—Ar1—X2—Y—X3—Ar2 (wherein X1, X2, and X3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N?, ?N—, —NR1—, —O—, etc.; Y represents —NR2CO— or —CONR2— (wherein R2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.Type: ApplicationFiled: November 24, 2005Publication date: April 24, 2008Inventors: Hirokazu Arimoto, Jun Lu, Yoshinori Yamano, Tatsuro Yasukata, Osamu Yoshida, Tsutomu Iwaki, Yutaka Yoshida, Issei Kato, Kenji Morimoto, Kayo Yasoshima
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Publication number: 20050153950Abstract: A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.Type: ApplicationFiled: March 18, 2003Publication date: July 14, 2005Applicant: SHIONOGI & CO., LTD.Inventors: Yasuhiro Nishitani, Yoshinori Yamano
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Patent number: 5217833Abstract: A method of producing a fluorescent screen of a cathode-ray tube inclusive of a process to form carbon stripes by coating an inner surface of a panel with a carbon film and then drying, exposing and developing such a carbon film. The method comprises the steps of perceiving the carbon stripes on the inner surface of the panel as video information by optical means, then inputting the video information to an image processor to calculate the line widths of the carbon stripes, and controlling the exposure during the carbon stripe exposure process on the basis of the line widths thus calculated. According to this method, the line widths of the carbon stripes can be maintained constant to enhance the quality stability, and the measuring operation is remarkably simplified by a completely automated mechanical system.Type: GrantFiled: February 19, 1992Date of Patent: June 8, 1993Assignee: Sony CorporationInventors: Takehiro Yamanaka, Susumu Saikawa, Yoshinori Yamano
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Patent number: 4883439Abstract: A cathode ray tube fixturing device for position a face panel and a funnel during a frit sealing process. The device includes a cone holder for positioning a constricted portion of the funnel, and a movable abutting block which is adapted to abut against the panel and the funnel. A pivoting arm connects the cone holder with the movable abutting block, and at least one fixed abutting block is adapted to abut against the panel and the funnel and is located in opposed relationship with respect to the movable abutting block. When the funnel and the panel are mounted in the cone holder in assembled relation, their common centerline is vertical. In this assembled relation, the panel and funnel are urged against the fixed abutting block by the movable abutting block so that the seal from the panel to the funnel can be effectively produced and the fixturing device is reduced in weight.Type: GrantFiled: December 7, 1987Date of Patent: November 28, 1989Assignee: Sony CorporationInventors: Tatsurou Sakamoto, Masayoshi Ito, Yoshinori Yamano