Patents by Inventor Yoshinori Yamashita
Yoshinori Yamashita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030141390Abstract: A stationary core has a press fitting portion and is secured to an inner peripheral wall of a tubular member by press fitting, so that an outer peripheral wall of the press fitting portion of the stationary core is engaged with the inner peripheral wall of the tubular member, and a radial space is formed upstream of the press fitting portion of the stationary core between the stationary core and the tubular member. The stationary core can have a tapered annular outer surface section, which is arranged in an outer peripheral wall of a downstream end portion of the stationary core and is tapered toward a downstream end of the stationary core at a taper angle of 2 to 60 degrees to have a reduced outer diameter.Type: ApplicationFiled: December 31, 2002Publication date: July 31, 2003Inventors: Tetsuharu Matsuo, Yoshinori Yamashita, Takayuki Hokao
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Patent number: 6518268Abstract: Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.Type: GrantFiled: June 30, 2000Date of Patent: February 11, 2003Assignees: Geron Corporation, Kyowa Hakko Kogyo Co., Ltd.Inventors: Allison C. Chin, Ryan Holcomb, Mieczyslaw A. Piatyszek, Upinder Singh, Richard L. Tolman, Tsutomu Akama, Yutaka Kanda, Akira Asai, Yoshinori Yamashita, Kaori Endo, Hiroyuki Yamaguchi
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Patent number: 6487431Abstract: A radiographic apparatus is disclosed, which allows a biopsy needle or a drug injection needle to be run into a patient accurately and quickly. Once a needle entry point on a body surface of the patient and a target point in the patient are designated and inputted on the screen of a display monitor, the radiographic apparatus in this invention automatically displays, en block on the display monitor, a guideline linking the two points, intersection marks indicative of intersections of the guideline and CT images, and angles and length serving as a reference for determining a direction and depth of running the needle. The operator has only to run the needle to a required depth along the guideline and intersection marks in the direction indicated by the angles displayed. Thus, the biopsy needle or injection needle may be run into the patient accurately and quickly.Type: GrantFiled: September 15, 1999Date of Patent: November 26, 2002Assignee: Shimadzu CorporationInventors: Teruaki Iwano, Yoshinori Yamashita, Takashi Marume
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Patent number: 6165398Abstract: A method of slip casting using a casting mold provided with a water-absorbent layer that has a self-water-absorbent ability, substantially has a water resistance, and is controlled in the saturated water content thereof, the slip casting being conducted by employing mainly a capillary sucking force as the driving force of the water-absorbent layer of cast formation. An open-cell porous body usable as the water-absorbent layer is produced by agitating a mixture comprising a compound having at least one epoxy ring in its molecule, a curing agent which cures the epoxy compound by reaction, a filler developing for a self-water-absorbent ability and a mold release property, and water to prepare an O/W emulsion slurry and curing the slurry, as such in a hydrous state.Type: GrantFiled: February 26, 1998Date of Patent: December 26, 2000Assignee: Toto Ltd.Inventors: Akio Matsumoto, Takeshi Sato, Yoshifumi Misumi, Akira Hirayama, Katsuhiro Hasebe, Yoshinori Yamashita
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Patent number: 5977165Abstract: The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.Type: GrantFiled: October 27, 1997Date of Patent: November 2, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsutomu Agatsuma, Yutaka Saitoh, Yoshinori Yamashita, Tamio Mizukami, Shiro Akinaga, Katsushige Gomi, Kazuhito Akasaka, Isami Takahashi
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Patent number: 5965604Abstract: The present invention relates to chrolactomycin compound represented by the following formula (I): ##STR1## or pharmaceutically acceptable salts thereof having antibacterial and antitumor activities.Type: GrantFiled: December 17, 1998Date of Patent: October 12, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoshinori Yamashita, Ryuichiro Nakai, Tamio Mizukami, Shingo Kakita, Shigeru Chiba, Shiro Akinaga
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Patent number: 5826472Abstract: A wire processing apparatus is provided with a prefeeder 120, a feeding unit 12 and an accumulator 110 therebetween. A detector is provided to determine if there is a cause for stopping the prefeeder 120. In response to such a detected cause, a controller stops the prefeeder 120 while simultaneously permitting the feeding unit 12 to draw a wire from the accumulator to permit continued operation of the wire processing apparatus.Type: GrantFiled: September 12, 1996Date of Patent: October 27, 1998Assignee: Sumitomo Wiring Systems, Ltd.Inventors: Yoshikazu Tamura, Yoshinori Yamashita
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Patent number: 5798379Abstract: UCS1025 compounds represented by the following formula (I): ##STR1## wherein R represents hydrogen or hydroxyl group, or tautomers or pharmacologically acceptable salts thereof.Type: GrantFiled: December 18, 1997Date of Patent: August 25, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tamio Mizukami, Harumi Ogawa, Ryuichiro Nakai, Akira Asai, Yoshinori Yamashita, Katsuhiko Ando, Tsutomu Agatsuma, Shiro Akinaga, Kozo Ouchi, Hideki Kawasaki
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Patent number: 5717110Abstract: This invention relates to UCH15 compounds of the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a hydroxyl group.Type: GrantFiled: May 12, 1997Date of Patent: February 10, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tamio Mizukami, Akira Asai, Yoshinori Yamashita, Hirofumi Nakano, Shingo Kakita, Youichi Uosaki, Keiko Ochiai, Tadashi Ashizawa, Akira Mihara
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Patent number: 5663298Abstract: The present invention relates to UCK14 compounds having antitumor activity which are represented by the formula: ##STR1## wherein R.sup.1 is hydrogen or --COOC(CH.sub.3).sub.3 ; and R.sup.2 and R.sup.3 are taken together to form --CH.sub.2 --, or each R.sup.2 and R.sup.3 independently are hydrogen,and pharmaceutically acceptable salts thereof.Type: GrantFiled: October 15, 1996Date of Patent: September 2, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tamio Mizukami, Akira Asai, Yoshinori Yamashita, Ritsuko Katahira, Atsuhiro Hasegawa, Keiko Ochiai, Shiro Akinaga
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Patent number: 5656736Abstract: The present invention relates to the compound UCH9 represented by the following formula: ##STR1## which has antibacterial and anti-tumor activity, and pharmaceutically acceptable salts thereof.Type: GrantFiled: April 21, 1995Date of Patent: August 12, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hirofumi Nakano, Harumi Ogawa, Yoshinori Yamashita, Ritsuko Katahira, Shigeru Chiba, Toshiaki Iwasaki, Tadashi Ashizawa
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Patent number: 5522717Abstract: A mold for pressure-cast-molding a ceramic article having a filter material made of an open-cell porous material. The open-cell porous material is prepared by stirring a mixture of a resin material, a microballoon, a curing agent and water to provide an emulsion slurry, casting the slurry in a water-impermeable mold and curing the slurry in the water-containing state. The portions occupied by the water during the preparation of the porous material mainly form open pores.Type: GrantFiled: February 24, 1995Date of Patent: June 4, 1996Assignee: Toto Ltd.Inventors: Akio Matsumoto, Shingo Kasahara, Yoshifumi Misumi, Yoshinori Yamashita
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Patent number: 5510501Abstract: The present invention relates to Saintopin derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is SO.sub.2 OH (UCE 1022), or R.sup.1 is acetyl and R.sup.2 is H (Saintopin E), which are useful as antibacterial and anti-tumor agents.Type: GrantFiled: July 21, 1994Date of Patent: April 23, 1996Assignee: Kyowa Hakko Kogyo, Co. Ltd.Inventors: Hirofumi Nakano, Noboru Fujii, Yoshinori Yamashita, Yutaka Saitoh, Tsutomu Agatsuma, Katsuhiko Ando, Yasushi Nishiie, Katsunori Kita, Naoki Morishima, Katsushige Gomi
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Patent number: 5366966Abstract: A compound represented by formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is provided, which has an excellent antitumor activity.Type: GrantFiled: June 4, 1993Date of Patent: November 22, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hirofumi Nakano, Noboru Fujii, Yoshinori Yamashita, Youichi Uosaki, Shigeru Chiba, Shigeo Katsumata, Yukari Tsuji
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Patent number: 5259272Abstract: In a continuously variable transmission of the type in which a speed change ratio is changed in a manner that the radius of rotation of a belt wound around a drive pulley and a driven pulley is varied by changing the width of a groove between the pulley parts of each pulley with an oil pressure. A control means for controlling an oil pressure in various control modes shifts the control mode from a hold mode to a start mode, when a driver manipulates a vehicle carrying the continuously variable transmission with his intention to start the vehicle, and an amount of discharge flow of an oil pump for generating an oil pressure exceeds a preset value. The safety factor in a stationary state is calculated using the effective tension of the CVT belt, secondary side oil pressure, and the speed change ratio.Type: GrantFiled: September 25, 1992Date of Patent: November 9, 1993Assignees: Mitsubishi Denki K.K., Suzuki Motor Corp.Inventors: Hiroaki Yamamoto, Yoshinori Yamashita, Katsuhiko Taniguchi
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Patent number: 5170868Abstract: A method of controlling a friction type clutch of a vehicle having an engine and a drive train, which clutch is operated by hydraulic oil and is frictionally engageable to transfer rotational driving force from an output shaft of the engine to the drive train, includes the steps of causing the clutch to assume a slipping state of engagement upon starting of the vehicle, and defining a first amount of time as a function of the temperature of the hydrauilc oil. When the first amount of time has elapsed since the starting of the vehicle, the clutch is positively urged from slipping state of engagement into a locked up state of engagement.Type: GrantFiled: October 11, 1991Date of Patent: December 15, 1992Assignees: Suzuki Motor Corporation, Mitsubishi Denki Kabushiki KaishaInventors: Yoshinori Yamashita, Hiroaki Yamamoto
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Patent number: 5131297Abstract: A shift control method is provided for controlling shifting in a continuously variable transmission. The transmission changes a gear ratio by increasing or decreasing the turning radius of a belt installed on a pair of pulleys. Each pulley includes a fixed pulley member and a movable pulley member, and the belt turning radius is varied by varying the width of a groove defined between the respective pulley members. The transmission has a shift control range associated therewith which is determined on the basis of the component structural elements thereof, and this shift control range is bounded by a ratio line. The shift control method includes providing a control means for setting a target engine speed according to input throttle opening and vehicle speed information, and setting a limit value of said target engine speed in the vicinity of the ratio line but outside of the shift control range.Type: GrantFiled: February 28, 1991Date of Patent: July 21, 1992Assignees: Suzuki Motor Corporation, Mitsubishi Denki Kabushiki KaishaInventors: Yoshinori Yamashita, Hiroaki Yamamoto
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Patent number: 5114383Abstract: An apparatus for controlling a continuously variable vehicle transmission includes a fixed pulley member and a movable pulley member which is supported for movement toward and away from the fixed pulley member. A groove defined between the pulley members has a width which is decreased and increased to thereby respectively increase and decrease the rotational radius of a belt which is received in the groove. A control arrangement executes speed change control to change the belt ratio. The control arrangement includes a control unit which receives throttle opening degree and vehicle velocity detection signals and determines first and second target engine rotational speed which are based respectively on these detection signals. The control unit determines an optimum target engine rotational speed based on the firt and second target engine rotational speeds and sets upper and lower limit values of the optimum target engine rotational speed in accordance with predetermined conditions.Type: GrantFiled: June 12, 1991Date of Patent: May 19, 1992Assignees: Suzuki Jidosha Kogyo Kabushiki Kaisha, Mitsubishi Denki Kabushiki KaishaInventors: Sadayuki Hirano, Yoshinori Yamashita, Takumi Tatsumi, Hiroaki Yamamoto
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Patent number: 5082096Abstract: A control apparatus for an automatic clutch device which comprises a primary pressure controlling valve for controlling a primary pressure in an oil clutch, a line pressure controlling valve for controlling a line pressure in the oil clutch, a clutch pressure controlling valve for controlling a clutch pressure in the oil clutch, first, second and third electromagnetic valves for controlling respectively the primary pressure controlling valve, the line pressure controlling valve and the clutch pressure controlling valve, and a control section which controls the first, second and third electromagnetic valves and effects a feed-back control of engine speed to the third electromagnetic valve, and which stores values obtained by the learning of feedback quantities of the engine speed until the last time and changes a clutch pressure control duty to the third electromagnetic valve by modifying a feed forward quantity with the value by learning.Type: GrantFiled: October 4, 1990Date of Patent: January 21, 1992Assignees: Mitsubishi Denki K.K., Suzuki Motor CorporationInventors: Yoshinori Yamashita, Hiroaki Yamamoto
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Patent number: 5079376Abstract: Disclosed is novel compound UCT-1003 represented by the following formula: ##STR1## and having anti-tumor activity. UCT-1003 is produced by culturing a microorganism belonging to the genus Paecilomyces.Type: GrantFiled: January 23, 1990Date of Patent: January 7, 1992Assignee: Kyowa Hakko Kogyo, Ltd.Inventors: Hirofumi Nakano, Yoshinori Yamashita, Katsuhiko Ando, Yutaka Saito, Keiichi Takahashi, Hiroe Ohno