Patents by Inventor Yoshinori Yamashita

Yoshinori Yamashita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030141390
    Abstract: A stationary core has a press fitting portion and is secured to an inner peripheral wall of a tubular member by press fitting, so that an outer peripheral wall of the press fitting portion of the stationary core is engaged with the inner peripheral wall of the tubular member, and a radial space is formed upstream of the press fitting portion of the stationary core between the stationary core and the tubular member. The stationary core can have a tapered annular outer surface section, which is arranged in an outer peripheral wall of a downstream end portion of the stationary core and is tapered toward a downstream end of the stationary core at a taper angle of 2 to 60 degrees to have a reduced outer diameter.
    Type: Application
    Filed: December 31, 2002
    Publication date: July 31, 2003
    Inventors: Tetsuharu Matsuo, Yoshinori Yamashita, Takayuki Hokao
  • Patent number: 6518268
    Abstract: Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: February 11, 2003
    Assignees: Geron Corporation, Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Allison C. Chin, Ryan Holcomb, Mieczyslaw A. Piatyszek, Upinder Singh, Richard L. Tolman, Tsutomu Akama, Yutaka Kanda, Akira Asai, Yoshinori Yamashita, Kaori Endo, Hiroyuki Yamaguchi
  • Patent number: 6487431
    Abstract: A radiographic apparatus is disclosed, which allows a biopsy needle or a drug injection needle to be run into a patient accurately and quickly. Once a needle entry point on a body surface of the patient and a target point in the patient are designated and inputted on the screen of a display monitor, the radiographic apparatus in this invention automatically displays, en block on the display monitor, a guideline linking the two points, intersection marks indicative of intersections of the guideline and CT images, and angles and length serving as a reference for determining a direction and depth of running the needle. The operator has only to run the needle to a required depth along the guideline and intersection marks in the direction indicated by the angles displayed. Thus, the biopsy needle or injection needle may be run into the patient accurately and quickly.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: November 26, 2002
    Assignee: Shimadzu Corporation
    Inventors: Teruaki Iwano, Yoshinori Yamashita, Takashi Marume
  • Patent number: 6165398
    Abstract: A method of slip casting using a casting mold provided with a water-absorbent layer that has a self-water-absorbent ability, substantially has a water resistance, and is controlled in the saturated water content thereof, the slip casting being conducted by employing mainly a capillary sucking force as the driving force of the water-absorbent layer of cast formation. An open-cell porous body usable as the water-absorbent layer is produced by agitating a mixture comprising a compound having at least one epoxy ring in its molecule, a curing agent which cures the epoxy compound by reaction, a filler developing for a self-water-absorbent ability and a mold release property, and water to prepare an O/W emulsion slurry and curing the slurry, as such in a hydrous state.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: December 26, 2000
    Assignee: Toto Ltd.
    Inventors: Akio Matsumoto, Takeshi Sato, Yoshifumi Misumi, Akira Hirayama, Katsuhiro Hasebe, Yoshinori Yamashita
  • Patent number: 5977165
    Abstract: The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: November 2, 1999
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsutomu Agatsuma, Yutaka Saitoh, Yoshinori Yamashita, Tamio Mizukami, Shiro Akinaga, Katsushige Gomi, Kazuhito Akasaka, Isami Takahashi
  • Patent number: 5965604
    Abstract: The present invention relates to chrolactomycin compound represented by the following formula (I): ##STR1## or pharmaceutically acceptable salts thereof having antibacterial and antitumor activities.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: October 12, 1999
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yoshinori Yamashita, Ryuichiro Nakai, Tamio Mizukami, Shingo Kakita, Shigeru Chiba, Shiro Akinaga
  • Patent number: 5826472
    Abstract: A wire processing apparatus is provided with a prefeeder 120, a feeding unit 12 and an accumulator 110 therebetween. A detector is provided to determine if there is a cause for stopping the prefeeder 120. In response to such a detected cause, a controller stops the prefeeder 120 while simultaneously permitting the feeding unit 12 to draw a wire from the accumulator to permit continued operation of the wire processing apparatus.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: October 27, 1998
    Assignee: Sumitomo Wiring Systems, Ltd.
    Inventors: Yoshikazu Tamura, Yoshinori Yamashita
  • Patent number: 5798379
    Abstract: UCS1025 compounds represented by the following formula (I): ##STR1## wherein R represents hydrogen or hydroxyl group, or tautomers or pharmacologically acceptable salts thereof.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: August 25, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tamio Mizukami, Harumi Ogawa, Ryuichiro Nakai, Akira Asai, Yoshinori Yamashita, Katsuhiko Ando, Tsutomu Agatsuma, Shiro Akinaga, Kozo Ouchi, Hideki Kawasaki
  • Patent number: 5717110
    Abstract: This invention relates to UCH15 compounds of the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a hydroxyl group.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: February 10, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tamio Mizukami, Akira Asai, Yoshinori Yamashita, Hirofumi Nakano, Shingo Kakita, Youichi Uosaki, Keiko Ochiai, Tadashi Ashizawa, Akira Mihara
  • Patent number: 5663298
    Abstract: The present invention relates to UCK14 compounds having antitumor activity which are represented by the formula: ##STR1## wherein R.sup.1 is hydrogen or --COOC(CH.sub.3).sub.3 ; and R.sup.2 and R.sup.3 are taken together to form --CH.sub.2 --, or each R.sup.2 and R.sup.3 independently are hydrogen,and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 15, 1996
    Date of Patent: September 2, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tamio Mizukami, Akira Asai, Yoshinori Yamashita, Ritsuko Katahira, Atsuhiro Hasegawa, Keiko Ochiai, Shiro Akinaga
  • Patent number: 5656736
    Abstract: The present invention relates to the compound UCH9 represented by the following formula: ##STR1## which has antibacterial and anti-tumor activity, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: August 12, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Harumi Ogawa, Yoshinori Yamashita, Ritsuko Katahira, Shigeru Chiba, Toshiaki Iwasaki, Tadashi Ashizawa
  • Patent number: 5522717
    Abstract: A mold for pressure-cast-molding a ceramic article having a filter material made of an open-cell porous material. The open-cell porous material is prepared by stirring a mixture of a resin material, a microballoon, a curing agent and water to provide an emulsion slurry, casting the slurry in a water-impermeable mold and curing the slurry in the water-containing state. The portions occupied by the water during the preparation of the porous material mainly form open pores.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: June 4, 1996
    Assignee: Toto Ltd.
    Inventors: Akio Matsumoto, Shingo Kasahara, Yoshifumi Misumi, Yoshinori Yamashita
  • Patent number: 5510501
    Abstract: The present invention relates to Saintopin derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is SO.sub.2 OH (UCE 1022), or R.sup.1 is acetyl and R.sup.2 is H (Saintopin E), which are useful as antibacterial and anti-tumor agents.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: April 23, 1996
    Assignee: Kyowa Hakko Kogyo, Co. Ltd.
    Inventors: Hirofumi Nakano, Noboru Fujii, Yoshinori Yamashita, Yutaka Saitoh, Tsutomu Agatsuma, Katsuhiko Ando, Yasushi Nishiie, Katsunori Kita, Naoki Morishima, Katsushige Gomi
  • Patent number: 5366966
    Abstract: A compound represented by formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is provided, which has an excellent antitumor activity.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: November 22, 1994
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Noboru Fujii, Yoshinori Yamashita, Youichi Uosaki, Shigeru Chiba, Shigeo Katsumata, Yukari Tsuji
  • Patent number: 5259272
    Abstract: In a continuously variable transmission of the type in which a speed change ratio is changed in a manner that the radius of rotation of a belt wound around a drive pulley and a driven pulley is varied by changing the width of a groove between the pulley parts of each pulley with an oil pressure. A control means for controlling an oil pressure in various control modes shifts the control mode from a hold mode to a start mode, when a driver manipulates a vehicle carrying the continuously variable transmission with his intention to start the vehicle, and an amount of discharge flow of an oil pump for generating an oil pressure exceeds a preset value. The safety factor in a stationary state is calculated using the effective tension of the CVT belt, secondary side oil pressure, and the speed change ratio.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: November 9, 1993
    Assignees: Mitsubishi Denki K.K., Suzuki Motor Corp.
    Inventors: Hiroaki Yamamoto, Yoshinori Yamashita, Katsuhiko Taniguchi
  • Patent number: 5170868
    Abstract: A method of controlling a friction type clutch of a vehicle having an engine and a drive train, which clutch is operated by hydraulic oil and is frictionally engageable to transfer rotational driving force from an output shaft of the engine to the drive train, includes the steps of causing the clutch to assume a slipping state of engagement upon starting of the vehicle, and defining a first amount of time as a function of the temperature of the hydrauilc oil. When the first amount of time has elapsed since the starting of the vehicle, the clutch is positively urged from slipping state of engagement into a locked up state of engagement.
    Type: Grant
    Filed: October 11, 1991
    Date of Patent: December 15, 1992
    Assignees: Suzuki Motor Corporation, Mitsubishi Denki Kabushiki Kaisha
    Inventors: Yoshinori Yamashita, Hiroaki Yamamoto
  • Patent number: 5131297
    Abstract: A shift control method is provided for controlling shifting in a continuously variable transmission. The transmission changes a gear ratio by increasing or decreasing the turning radius of a belt installed on a pair of pulleys. Each pulley includes a fixed pulley member and a movable pulley member, and the belt turning radius is varied by varying the width of a groove defined between the respective pulley members. The transmission has a shift control range associated therewith which is determined on the basis of the component structural elements thereof, and this shift control range is bounded by a ratio line. The shift control method includes providing a control means for setting a target engine speed according to input throttle opening and vehicle speed information, and setting a limit value of said target engine speed in the vicinity of the ratio line but outside of the shift control range.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: July 21, 1992
    Assignees: Suzuki Motor Corporation, Mitsubishi Denki Kabushiki Kaisha
    Inventors: Yoshinori Yamashita, Hiroaki Yamamoto
  • Patent number: 5114383
    Abstract: An apparatus for controlling a continuously variable vehicle transmission includes a fixed pulley member and a movable pulley member which is supported for movement toward and away from the fixed pulley member. A groove defined between the pulley members has a width which is decreased and increased to thereby respectively increase and decrease the rotational radius of a belt which is received in the groove. A control arrangement executes speed change control to change the belt ratio. The control arrangement includes a control unit which receives throttle opening degree and vehicle velocity detection signals and determines first and second target engine rotational speed which are based respectively on these detection signals. The control unit determines an optimum target engine rotational speed based on the firt and second target engine rotational speeds and sets upper and lower limit values of the optimum target engine rotational speed in accordance with predetermined conditions.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: May 19, 1992
    Assignees: Suzuki Jidosha Kogyo Kabushiki Kaisha, Mitsubishi Denki Kabushiki Kaisha
    Inventors: Sadayuki Hirano, Yoshinori Yamashita, Takumi Tatsumi, Hiroaki Yamamoto
  • Patent number: 5082096
    Abstract: A control apparatus for an automatic clutch device which comprises a primary pressure controlling valve for controlling a primary pressure in an oil clutch, a line pressure controlling valve for controlling a line pressure in the oil clutch, a clutch pressure controlling valve for controlling a clutch pressure in the oil clutch, first, second and third electromagnetic valves for controlling respectively the primary pressure controlling valve, the line pressure controlling valve and the clutch pressure controlling valve, and a control section which controls the first, second and third electromagnetic valves and effects a feed-back control of engine speed to the third electromagnetic valve, and which stores values obtained by the learning of feedback quantities of the engine speed until the last time and changes a clutch pressure control duty to the third electromagnetic valve by modifying a feed forward quantity with the value by learning.
    Type: Grant
    Filed: October 4, 1990
    Date of Patent: January 21, 1992
    Assignees: Mitsubishi Denki K.K., Suzuki Motor Corporation
    Inventors: Yoshinori Yamashita, Hiroaki Yamamoto
  • Patent number: 5079376
    Abstract: Disclosed is novel compound UCT-1003 represented by the following formula: ##STR1## and having anti-tumor activity. UCT-1003 is produced by culturing a microorganism belonging to the genus Paecilomyces.
    Type: Grant
    Filed: January 23, 1990
    Date of Patent: January 7, 1992
    Assignee: Kyowa Hakko Kogyo, Ltd.
    Inventors: Hirofumi Nakano, Yoshinori Yamashita, Katsuhiko Ando, Yutaka Saito, Keiichi Takahashi, Hiroe Ohno