Patents by Inventor Yoshio Aramaki
Yoshio Aramaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20100130737Abstract: The present invention provides a GPR receptor function regulator comprising the compound represented by the formula: [wherein ring A is an optionally substituted isocyclic or heterocyclic ring, P is a bond or spacer, ring D is an optionally substituted monocyclic aromatic ring which may be condensed with a 5- to 7-membered ring, V is a bond or the group represented by the formula —CR14?CR15— or —N?CR16— (wherein R14, R15 and R16 each represents a hydrogen atom or optionally substituted hydrocarbon group), Q is a bond or spacer, and W is a carboxyl or a group biologically equivalent to a carboxyl] or its salt or a prodrug thereof.Type: ApplicationFiled: February 17, 2006Publication date: May 27, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Fumio Itoh, Eiji Kimura, Yumi Imai, Masaaki Mori, Yoshio Aramaki, Yasuhisa Kohara, Tsukasa Sugo, Yoji Hayase, Hiromi Kobayashi, Kazuhiro Ogi
-
Patent number: 7262185Abstract: The present invention provides a novel benzazepine derivative represented by formula: wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula —W1—X2—W2— (W1 and W2 are independently S(O)m1 (m1 is 0, 1, or 2), etc., and X2 is an optionally substituted alkylene group etc.), a preparation method and use thereof.Type: GrantFiled: August 7, 2002Date of Patent: August 28, 2007Assignee: Takeda Chemical Industries Ltd.Inventors: Mitsuru Shiraishi, Masanori Baba, Masaki Seto, Yoshio Aramaki, Naoyuki Kanzaki, Naoki Miyamoto, Yuji Iizawa
-
Patent number: 6936602Abstract: Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1 is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1 and Z2 are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2 and R3 are each optionally substituted aliphatic hydrocarbyl or an optionally Substituted hetero-alicyclic group.Type: GrantFiled: June 15, 2000Date of Patent: August 30, 2005Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Masanori Baba, Yoshio Aramaki, Naoyuki Kanzaki, Osamu Nishimura
-
Publication number: 20040235822Abstract: The present invention provides a novel benzazepine derivative represented by formula: 1Type: ApplicationFiled: February 5, 2004Publication date: November 25, 2004Inventors: Mitsuru Shiraishi, Masanori Baba, Masaki Seto, Yoshio Aramaki, Naoyuki Kanzaki, Naoki Miyamoto, Yuji Iizawa
-
Patent number: 6413947Abstract: This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an, optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.Type: GrantFiled: September 13, 2000Date of Patent: July 2, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Takahito Kitayoshi, Yoshio Aramaki, Susumu Honda, Tsuneo Oda
-
Patent number: 6376536Abstract: This invention is to provide a compound for antagonizing CCR5, said compound being represented by the formula: wherein R1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is —CH2—, —S— or —O—; and R2, R3 and R4 are independently an optionally substituted aliphatic hydrocarbon group or an optionally substituted alicyclic heterocyclic ring group, and being effective for the prevention and treatment of infectious disease of HIV.Type: GrantFiled: May 26, 2000Date of Patent: April 23, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Masanori Baba, Yoshio Aramaki, Osamu Nishimura, Naoyuki Kanzaki
-
Patent number: 6268354Abstract: This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof.Type: GrantFiled: September 13, 2000Date of Patent: July 31, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Osamu Nishimura, Masanori Baba, Hidekazu Sawada, Naoyuki Kanzaki, Ken-ichi Kuroshima, Mitsuru Shiraishi, Yoshio Aramaki
-
Patent number: 6172061Abstract: This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof.Type: GrantFiled: December 17, 1998Date of Patent: January 9, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Osamu Nishimura, Masanori Baba, Hidekazu Sawada, Naoyuki Kanzaki, Ken-ichi Kuroshima, Mitsuru Shiraishi, Yoshio Aramaki
-
Patent number: 6166006Abstract: This invention is to provide a compound of the formula: ##STR1## wherein R.sup.1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: ##STR2## wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R.sup.2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.Type: GrantFiled: December 17, 1998Date of Patent: December 26, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Takahito Kitayoshi, Yoshio Aramaki, Susumu Honda, Tsuneo Oda
-
Patent number: 6096780Abstract: This invention is to provide a compound for antagonizing CCR5, said compound being represented by the formula: ##STR1## wherein R.sup.1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is --CH.sub.2 --, --S-- or --O--; and R.sup.2, R.sup.3 and R.sup.4 are independently an optionally substituted aliphatic hydrocarbon group or an optionally substituted alicyclic heterocyclic ring group, and being effective for the prevention and treatment of infectious disease of HIV.Type: GrantFiled: August 19, 1999Date of Patent: August 1, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Masanori Baba, Yoshio Aramaki, Osamu Nishimura, Naoyuki Kanzaki
-
Patent number: 5420275Abstract: An assay method which comprises utilizing chemiluminescence of a pyridopyridazine compound of the formula ##STR1## wherein R.sub.1 is a hydrocarbon group or a heterocyclic group each of which may be substituted and R.sub.2 is hydroxy group, thiol group, amino group or a monosubstituted amino group, and when R.sub.2 is a monosubstituted amino group, R.sub.2 may be taken together with R.sub.1 to form the ring; R.sub.3 is hydrogen atom, a hydroxy group which may be substituted, an amino group which may be substituted, a thiol group which may be substituted, a halogen atom, a heterocyclic group, nitro group, cyano group, carboxyl group which may be esterified or amidated, azido group, sulfo group or an organic sulfonyl group, provided that when R.sub.1 is an aliphalic group, R.sub.3 is not hydrogen atom; and X is oxygen atom or sulfur atom/or a salt thereof; and a novel compound of the formula (I) wherein the symbols are as defined above with proviso that R.sub.3 is hydrogen atom, R.sub.Type: GrantFiled: November 2, 1993Date of Patent: May 30, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirotomo Masuya, Yoshio Aramaki
-
Patent number: 5246968Abstract: A compound having glutamate receptor inhibitor activity represented by the formula: ##STR1## where R represents a hydrogen atom or a group of the formula: ##STR2## m and n each represents an integer of 3 or 4 and p represents an integer of 0 or 1, or a salt thereof is provided. The compounds are useful for an insecticide.Type: GrantFiled: June 30, 1992Date of Patent: September 21, 1993Assignees: Takeda Chimical Industries, Ltd., Tokyo Metropolitan Institute for NeurosciencesInventors: Terumi Nakajima, Yoshio Aramaki, Tadashi Yasuhara, Tsutomu Higashijima, Nobufumi Kawai, Akiko Miwa, Masanori Yoshioka