Abstract: Present invention is to provide a sustained-release composition which contains a physiologically active substance in high content even when gelatin is not included, and suppresses its initial excessive release and, thus, can achieve a stable release rate over about one month. A sustained-release composition containing a lactic acid-glycolic acid polymer having a ratio or weight average molecular weight and number average molecular weight of about 1.90 or lower, or a salt thereof, and a physiologically active substance.

Abstract: A process for producing a biodegradable polymer having free carboxyl at the &ohgr;-end charcterized by polymerizing a cyclic ester compound in the presence of a hydroxymonocarboxylic acid derivative having protected carboxyl or a hydroxydicarboxylic acid derivative having protected carboxyl, and then deprotecting the thus obtained polymer having protected carboxyl at the &ohgr;-end. Use of the above process makes it easy to control the molecular weight of the target biodegradable polymer and the content of free carboxyl therein, thereby enabling the efficient production of a polymer having a high purity and being contaminated with littel catalyst remaining therein.

Abstract: The present invention relates to a process for producing a sustained-release preparation comprising removing a solvent from an organic solvent solution containing a poorly water-soluble nonpeptidic physiologically active compound, a polyvalent metal compound and a biodegradable polymer, said physiologically active compound dissolved in an amount exceeding the solubility thereof in the organic solvent solution of biodegradable polymer in the absence of the polyvalent metal compound; a sustained-release preparation obtained by the process; a sustained-release solid pharmaceutical composition comprising a nonpeptidic physiologically active substance and a biodegradable polymer, wherein about 0.05% by weight or more, based on the weight of the composition, of a polyvalent metal is present on the surface of the composition; etc.

Abstract: A sustained-release composition containing a hydroxynaphthoic acid salt of a biologically active substance and a biodegradable polymer, a method of its production, and a pharmaceutical composition containing said sustained-release composition.

Abstract: A sustained-release preparation comprising a bioactive substance having an acidic group and a biodegradable polymer having an optionally protected basic group which improves the rate of incorporation of the bioactive substance, suppresses its leakage early after adminstration, and exhibits constantly suppressed release for an extended period of time.

Abstract: A composition prepared by containing or blending a physiologically active non-peptide substance and a biodegradable polymer having two or more carboxylic groups at its end or a salt thereof features: (1) larger content of the physiologically active non-peptide substance can be contained, as well as release of the same can be controlled or accelerated, whereby secure pharmaceutical effect is achieved; (2) when the physiologically active non-peptide substance causes subcutaneous stimulation, an activity of canceling the stimulation by strongly acidic group at its end is expected; and (3) high glass transition point and high stability.

Abstract: A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.

Abstract: A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided.

Abstract: A sustained-release preparation comprising a bioactive substance having an acidic group and a biodegradable polymer having improves the rate of incorporation of the bioactive substance, suppresses its leakage early after administration, and exhibits constantly suppressed release for an extended period of time.

Abstract: A sustained-release preparation comprising a bioactive substance having an acidic group and a biodegradable polymer having an optionally protected basic group which improves the rate of incorporation of the bioactive substance, suppresses its leakage early after administration, and exhibits constantly suppressed release for an extended period of time.

Abstract: A disk cartridge (21) for loading on a flat tray (1) included in a disk loading apparatus. Recesses (29) are provided on the back side of the disk cartridge near the rear end (27a) thereof, and projections (16) are provided on the tray for judging whether the disk cartridge is loaded properly on the tray. In addition, notches (30) are formed on the right (27d) and left (27c) sides of the disk cartridge between the recesses and the rear end thereof for engagement with an automatic cartridge-changer.

Abstract: A disk cartridge (21) for loading on a flat tray (1) included in a disk loading apparatus, wherein positioning holes (28) are provided at the rear end (27a), on a peripheral side, of the disk cartridge, and protrusions (18) are formed on the tray providing for a rigid positioning of the cartridge in order to fix the cartridge at the specified position on the tray. In addition, a groove (32) is formed on the face side and on the back side of the cartridge extending in a lateral direction, and a resin flow inlet (33) is provided at the rear end (27a) to improve the productability of a thin portion (26) of the cartridge.

Abstract: A flat tray (1) for receiving a disk cartridge (21) for a disk loading apparatus, wherein positioning holes (28) are provided at the rear end (27a), on a peripheral side, of the disk cartridge, and protrusions (18) are formed on the tray providing for a rigid positioning of the cartridge in order to fix the cartridge at the specified position on the tray. The protrusions (18) may be made of leaf springs that are formed with one end curved. When the disk cartridge (21) is pushed into the tray (1), the curved portions of the protrusions match the positioning holes (28) on the disk cartridge.

Abstract: A disk cartridge (21) for loading on a flat tray (1) included in a disk loading apparatus, wherein an inclined groove (32) is formed on the face side (22a) and the back side (22b) of the disk cartridge to extend in the moving direction of the shutter (23). A resin flow inlet (33) is provided at the rear end (27a) to improve the productability of the thin part of the cartridge. The inclination of the groove enables to detect when a wrong side of the disk cartridge is put on the tray.

Abstract: An armature of a three-phase magneto for generating three-phase AC output has a core having a plurality of magnetic poles arranged in an annular array on the periphery thereof. The armature has three series winding circuits corresponding to the respective phases, each series winding circuit including series-connected windings wound on every three magnetic poles. The winding direction of the windings of one of the three series winding circuits is opposite to the winding direction of the windings of the other two series winding circuits. The armature also has three connection conductors for connecting ends of the three series winding circuits into a delta connection and providing output terminals of the three-phase AC output.

Abstract: A mechanism for actuating a platen of a printer in which a cooperating pin and lever are provided to permit a plurality of printing rings with the desired characters thereon to be printed to be placed into a printing position, to move a platen into abutting engagement with the printing rings and hold them engaged for printing, all during a first period of time, and to remove the platen from the printing rings during a second period of time, and in which the first time period is about two to three times longer than the second time period so that the speed of the printer for each printing operation is increased.