Patents by Inventor Yoshio Hayase

Yoshio Hayase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6004952
    Abstract: The object of the present invention is to provide a novel compound which has various biological activities and is useful for medical and animal drugs. The present invention provides a compound represented by the formula: ##STR1## wherein R.sup.1 is COOR.sup.4, CONR.sup.5 R.sup.6, CO--R.sup.7 --OR or CH.sub.2 OR.sup.8 ; R.sup.2 is hydrogen atom, alkyl, aralkyl, heteroaryl, heteroarylalkyl, COR.sup.13, COOR.sup.14, CONR.sup.15 R.sup.16 ; R.sup.3 is hydrogen atom or OR.sup.3 ; a broken line ( - - - ) represents the presence of a double bond when R.sup.3 is oxygen atom and the absence of a double bond when R.sup.3 is OR.sup.3, or a salt or metal chelete thereof.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: December 21, 1999
    Assignee: Shinogi & Co., Ltd.
    Inventors: Yoshio Hayase, Shinobu Kobayashi, Kazuo Ueda, Shigetada Hidaka
  • Patent number: 5707838
    Abstract: The invention is a compound of the formula: ##STR1## wherein M is a bivalent or trivalent metal ion, and X is OH or O.sup..crclbar.. The above compound of the present invention is useful for prevention or treatment of mycoplasmosis.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: January 13, 1998
    Assignee: Shionogi & Co., Ltd.
    Inventors: Reiji Takeda, Shigetada Hidaka, Shinobu Kobayashi, Yoshio Hayase, Mamoru Ozaki, Hiroshi Nakai
  • Patent number: 5548078
    Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: August 20, 1996
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
  • Patent number: 5401877
    Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted sibyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH=CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: March 28, 1995
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
  • Patent number: 5371223
    Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: December 6, 1994
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
  • Patent number: 5371222
    Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: December 6, 1994
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
  • Patent number: 5360810
    Abstract: There is disclosed a compound of the formula (I): ##STR1## wherein X is a hydrogen atom or 1 to 5 substituents which may be the same or different and are selected from the group consisting of a hydrogen atom, alkyl, alkenyl, alkynyl, optionally substituted phenyl, an optionally substituted heterocyclic group, alkoxy, alkenyloxy, alkynyloxy, optionally substituted phenoxy, mono-, di- or tri-substituted halogenoalkyl and a halogen atom; Y is CH or N; m is 0 or 1; A is a group of the formula: ##STR2## (wherein R.sup.1 is a hydrogen atom or alkyl; n is 0 or 1; B is O, S or NR.sup.3 ; R.sup.2 and R.sup.3 are the same or different and are a hydrogen atom, alkyl, alkenyl, alkynyl, phenyl, benzyl, acyl or phenacyl). There are also disclosed the production thereof and an agricultural fungicide containing the compound as an active component.
    Type: Grant
    Filed: March 18, 1993
    Date of Patent: November 1, 1994
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hayase, Hideyuki Takenaka, Norihiko Tanimoto, Michio Masuko, Toshihiko Takahashi
  • Patent number: 5248687
    Abstract: There is disclosed a compound of the formula (I): ##STR1## wherein X is a hydrogen atom or 1 to 5 substituents which may be the same or different and are selected from the group consisting of a hydrogen atom, alkyl, alkenyl, alkynyl, optionally substituted phenyl, an optionally substituted heterocyclic group, alkoxy, alkenyloxy, alkynyloxy, optionally substituted phenoxy, mono-, di- or tri-substituted halogenoalkyl and a halogen atom; Y is CH or N; m is 0 or 1; A is a group of the formula: ##STR2## (wherein R.sup.1 is a hydrogen atom or alkyl; n is 0 or 1; B is O, S or NR.sup.3 ; R.sup.2 and R.sup.3 are the same or different and are a hydrogen atom, alkyl, alkenyl, alkynyl, phenyl, benzyl, acyl or phenacyl). There are also disclosed the production thereof and an agricultural fungicide containing the compound as an active component.
    Type: Grant
    Filed: August 3, 1992
    Date of Patent: September 28, 1993
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hayase, Hideyuki Takenaka, Norihiko Tanimoto, Michio Masuko, Toshio Takahashi
  • Patent number: 5185342
    Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.
    Type: Grant
    Filed: May 16, 1990
    Date of Patent: February 9, 1993
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
  • Patent number: 5089043
    Abstract: A heterocyclic oxy-phenoxyacetic acid derivative of the formula: ##STR1## , or its salt, which is useful as a herbicide.
    Type: Grant
    Filed: November 6, 1990
    Date of Patent: February 18, 1992
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hayase, Kohei Matsumoto, Kazuo Kamei, Kinya Ide, Toshio Takahashi
  • Patent number: 4720488
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each represent C.sub.1 -C.sub.5 alkoxy or C.sub.1 -C.sub.5 alkylthio, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each represent hydrogen or C.sub.1 -C.sub.5 alkyl, R.sup.7, R.sup.8 and R.sup.9 each represent hydrogen, C.sub.1 -C.sub.5 alkyl or halogen, and X represents oxygen or sulfur. A process for preparing the compound (I) and a pesticidal composition containing the compound (I) are also provided.
    Type: Grant
    Filed: December 8, 1986
    Date of Patent: January 19, 1988
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hayase, Mitsuhiro Ichinari, Kazuo Kamei, Junji Taguchi, Katsuaki Oba, Toshio Takahashi
  • Patent number: 4695312
    Abstract: A compound (I) of the formula: ##STR1## (wherein X and Y each is halogen) and herbicidal compositions containing the compound (I) are provided.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: September 22, 1987
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hayase, Toshikazu Ohtsuka, Kinya Ide, Toshio Takahashi
  • Patent number: 4681874
    Abstract: Novel thiazinephosphonic acid derivatives (I): ##STR1## wherein R.sup.1 and R.sup.2 each is lower alkoxy, lower alkynyloxy, lower alkylthio, arylthio (e.g., monocyclic aromatic group), or lower alkylamino; R.sup.3 and R.sup.4 each is hydrogen or lower alkyl; R.sup.5, R.sup.6, and R.sup.7 each is hydrogen, lower alyl, lower alkoxy, halogen, or trifluoromethyl; and X is oxygen or sulfur, are disclosed. A method for the production thereof, and pesticides comprising said compounds (I) are provided.
    Type: Grant
    Filed: September 6, 1985
    Date of Patent: July 21, 1987
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hayase, Mitsuhiro Ichinari, Junji Taguchi, Takeo Ishiguro, Toshio Takahashi
  • Patent number: 4663314
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each phenyl optionally substituted by one selected from the group consisting of C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkylthio, C.sub.1 -C.sub.5 alkylenedioxy, halogen, nitro, and halogeno-C.sub.1 -C.sub.5 alkoxy; R.sup.3 and R.sup.4 are each C.sub.1 -C.sub.5 alkyl; and Z is N or CH. A method for preparing the compound (I) and a pesticidal formulation containing the same are also provided.
    Type: Grant
    Filed: May 6, 1986
    Date of Patent: May 5, 1987
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hayase, Toshikazu Ohtsuka, Takeo Ishiguro, Toshio Takahashi
  • Patent number: 4648898
    Abstract: Novel triazine derivatives (I) and herbicides are provided. ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 each is hydrogen, aliphatic hydrocarbon residue, lower alkoxy-(lower alkyl), cyano-(lower alkyl), or aryl-(lower alkyl); or (R.sup.1 and R.sup.2) or (R.sup.3 and R.sup.4) taken together form lower alkylene.
    Type: Grant
    Filed: August 9, 1985
    Date of Patent: March 10, 1987
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshio Hayase, Koichi Morita, Kinya Ide, Toshio Takahashi
  • Patent number: D376066
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: December 3, 1996
    Assignee: Tanico Corporation
    Inventors: Tatsuo Taniguchi, Masayuki Fujimori, Yoshio Hayase