Patents by Inventor Yoshio Kozai

Yoshio Kozai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Deletion muteins of hst-1
    Patent number: 5639862
    Abstract: A deletion type mutein of heparin-binding secretory transforming factor (hst-1) possesses excellent cell growth promoting activity and is stable. The present mutein can therefore be used as a therapeutic medicine such as a healing promoter for burns, wounds, surgical injuries etc.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: June 17, 1997
    Assignees: President of National Cancer Center, Takeda Chemical Industries, Ltd.
    Inventors: Masaaki Terada, Hiromi Sakamoto, Teruhiko Yoshida, Koichi Igarashi, Yoshio Kozai
  • Imidazopyridine derivatives and their use
    Patent number: 5587383
    Abstract: A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: December 24, 1996
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Muneo Takatani, Yoshio Kozai, Kiminori Tomimatsu, Yumiko Shibouta
  • Imidazopyridine derivatives and their use
    Patent number: 5395839
    Abstract: A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: March 7, 1995
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Takatani Muneo, Yoshio Kozai, Kiminori Tomimatsu, Yumiko Shibouta
  • Cell proliferation inhibitor
    Patent number: 5272180
    Abstract: A compound of the formula: ##STR1## wherein, R.sup.1 and R.sup.2 are the same or different/representing methyl or methoxy groups, or form --CH.dbd.CH--CH.dbd.CH-- by binding to each other; R.sup.3 is an aromatic group or a heterocyclic group which may be substituted; and n is an integer of 2 to 8, shows inhibitory effect of cell proliferation and is useful as cell proliferation inhibitor.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: December 21, 1993
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Naoto Hashimoto, Kaneyoshi Kato, Yoshio Kozai
  • Imidazopyridine derivatives and their pharmaceutical use
    Patent number: 5244908
    Abstract: A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.
    Type: Grant
    Filed: July 30, 1991
    Date of Patent: September 14, 1993
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Muneo Takatani, Yoshio Kozai, Kiminori Tomimatsu, Yumiko Shibouta
  • Lipid derivatives, their production and use
    Patent number: 4737518
    Abstract: Novel lipid derivatives of the formula ##STR1## [wherein R.sup.1 is alkyl or alkylcarbamoyl; R.sup.2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R.sup.3 is a chemical binding or alkylene which may be substituted; R.sup.4 is hydrogen, alkyl or aralkyl; X and Y are independently O, S or an imino group which may be substituted, and when Y is an imino group, Y, together with the imino group represented by X or R.sup.4, may form a ring; and Z is imino or a nitrogen-containing heterocyclic ring which may be substituted] and salts thereof have inhibiting activity on platelet activating factor and are useful as a preventive or therapeutic agent for a variety of circulatory diseases and allergic disorders and also as an antineoplastic agent.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: April 12, 1988
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroaki Nomura, Kohei Nishikawa, Susumu Tsushima, Yoshio Kozai