Abstract: An ampoule guide and a drug solution administering unit having excellent stability. An ampoule guide (30) is provided with a hollow cylindrical guard (31) at a tipping portion and which accommodates therein an ampoule (20); a drug solution administering unit provided with an ampoule guide (30) which is provided with a hollow cylindrical guard (31) at a tipping portion and which accommodates therein an ampoule (20), a gasket (40) which is set within the ampoule (20) for accommodating and pushing out a drug solution, and a plunger activating portion (50) provided with a push-out mechanism for pushing out the gasket (40); and the like.

Abstract: An ampoule which is hard to crack on a barrel while increasing cleavability required for a hermetical container end. An ampoule (20) is provided with a front edge portion (1), a main body (2), a connection (3), and a joint (4), wherein a hermetical container end (10) which includes the front edge portion (1), the joint (4) and the connection (3) is formed separately from the main body (2), and the joint (4) breaks when a force is applied from a lateral direction with respect to the central axis (5), so that a head portion of the connection (3) which is circular truncated cone shaped is exposed and the space portion (13) of the connection (3) becomes an open end.

Abstract: An easy-to-open end portion of a hermetically sealed container contains a substantially flat opening surface. The opening surface is free of broken pieces when the end portion is opened. The container comprises a tip portion, a truncated conical coupling portion for coupling the tip portion and a body portion, and a joint portion, wherein the tip portion, the joint portion, the coupling portion, and the body portion are arranged coaxially to have a central axis, and space portions are provided to extend continuously from the body portion to the middle of the joint portion. The joint portion can be broken by applying a force from the lateral direction of the central axis on the tip portion. As a result, the head portion of the truncated conical portion is exposed and the space portion of the coupling portion becomes a free end.

Abstract: A novel bookbinding system, and bookbinding method, solving various problems attributed to the use of stapler needle. This is provided a bookbinding system, and bookbinding method, comprising, with respect to a book produced through application of an adhesive to printed sheets, sheet folding and cutting, making perforations for adhesive penetration along a fold line on the stitch side thereof, carrying out adhesive application on a line or in a broken line, and performing sheet folding and stitching.

Abstract: The object is to provide an ampoule usable as a syringe, and a syringe unit which are easy to handle, excellent in quantitative accuracy, and further more excellent in hygienic aspect. The above object is solved by an ampoule usable as a syringe comprising: a front edge portion (4) which is removed when the ampoule is used; an ampoule body (2) which can accommodate a drug solution (10); and a liquid infusing portion (3) connecting the front edge portion (4) and the ampoule body (2); the ampoule body (2) being able to place a movable stopper (5) in contact with an internal surface of the ampoule body (2), and being able to accommodate the drug solution (10) hermetically-sealed in the through-hole (6) between the movable stopper (5) and the sealing portion (4a).

Abstract: A film sheet having a pressure valve portion with one or more holes passing partially through the sheet film on one side of the sheet film, and a thin portion covering each of the one or more holes. The thin portion is preferably constructed to rupture when a predetermined maximum sustainable pressure differential is applied across the sheet film. In one embodiment, sheet film has a first film layer; and a second film layer, having one or more through holes, laminated to the first film layer. In another embodiment, the sheet film has a first film layer, a second film layer having one or more through holes, and a third film layer having one or more through holes, wherein the second film layer is laminated on one side of the first film layer, and the third film layer is laminated on the other side of the first film layer so that the one or more through holes of the second film layer are aligned with the one or more through holes of the third film layer.

Abstract: Human tissue plasminogen activator is produced by culturing a human rhabdomyosarcoma-derived cell, KYM-SF, in a medium, followed by purification of single-chain and/or double-chain human tissue plasminogen activator from the medium.

Abstract: A method of and an apparatus for assembling a slide fastener slider by fitting together a slider body having an attachment lug provided on the upper surface thereof and a pull tab having an aperture in the one end thereof. There is a large enough gap between a distal end of the attachment lug and the upper surface of the slider body to allow the distal end to pass through the aperture of the pull tab. The method is characterized by gradually pressing the distal end of the attachment lug toward the slider body as the slider body is transported along the transport path by using feed rollers having combined functions to constitute a die and to transport the slider body thereon as well as a punch roller.

Abstract: A feed mechanism for an elongate flexible article includes a pair of parallel grippers reciprocable between a first position and a second position for advancing the article along a longitudinal path. The grippers are closed at the first position to grip the article on a pair of spaced leading end portions thereof, and are opened at the second position to release the article. A removal lever, which has a first and a second leg, is disposed adjacent to the second position and is pivotable, in response to the arrival of the grippers at the second position, to cause the first leg to project through a space between the pair of grippers to kick down the article from the grippers while the latter are opened.

Abstract: A method of attaching bottom stops of a generally H-shaped cross section to a slide fastener chain. One of successive spaced pairs of opposed blank tape portions of the fastener chain is spread apart. A bottom stop, which has two pairs of gripping legs, is placed between the spread pair of opposed blank tape portions. The spread pair of opposed blank tape portions is then released and thereby allowed to come toward each other until a pair of opposed blank beaded tape edges are threaded one through a space between each pair of the gripping legs of the bottom stop. Then, the blank beaded tape edges are compressed against the bottom stop on opposite sides. Finally, the gripping legs of each pair are clinched about the compressed beaded edge of a respective one of the stringer tapes. An apparatus for carrying this method is also disclosed.

Abstract: Apparatus for applying top end stops to a continuous fastener chain is provided with camming means for taking a pressure roller into and out of engagement with its associated feed or drive roller at respective time points coincidental with the supplying of top end stops to the fastener chain and with the completion of clamping the end stops onto the fastener chain.