Patents by Inventor Yoshio Shimada

Yoshio Shimada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5846793
    Abstract: A process for preparing optically active (R)-3-chloro-1,2-propanediol, which comprises subjecting (R,S)-3-chloro-1,2-propanediol to the reaction of a microorganism belonging to genus Serratia in a reaction mixture, and then collecting the residual (R)-3-chloro-1,2-propanediol. According to the process of the present invention, (R)-3-chloro-1,2-propanediol can be efficiently prepared starting from low cost (R,S)-3-chloro-1,2-propanediol.
    Type: Grant
    Filed: December 27, 1990
    Date of Patent: December 8, 1998
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hideyuki Takahashi, Satoru Tsuda, Yoshio Nakamura, Masahiro Ogura, Tadayoshi Shiraishi, Yoshio Shimada, Kiyoshi Watanabe
  • Patent number: 5476155
    Abstract: A stairway lift is provided on the treads of a stairway along a sidewall. A guide of the lift is provided on the treads along the sidewall so that a space is formed between the sidewall and the guide. The guide has a first side that faces the sidewall, a first rail provided on the first side, a chain rack on the first side that extends along the sidewall and a second side that faces away from the sidewall. A mobile body is supported by the first rail in the space formed between the sidewall and the guide. The mobile body has a drive sprocket engageable with the chain rack and an electric motor coupled with the drive sprocket for rotatively driving the drive sprocket. A carrier is provided for carrying a person or object to be moved along the stairway. A coupling arrangement couples the mobile body and the carrier so that the carrier is removably supported by the mobile body on the second side of the guide and guided for travel by the guide.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: December 19, 1995
    Assignee: Daido Kogyo Co., Ltd.
    Inventors: Masato Nakatani, Hiroshi Kawai, Chikayuki Higashide, Yoshihiro Kitamura, Megumi Nishino, Yoshimasa Yamamoto, Hideo Kikuchi, Yoshio Shimada, Hidenori Suzuki, Hiroshi Aoki, Takahiro Shimizu
  • Patent number: 5202341
    Abstract: A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.
    Type: Grant
    Filed: July 25, 1991
    Date of Patent: April 13, 1993
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Tadayoshi Shiraishi, Keiji Kameyama, Takeshi Domoto, Naohiro Imai, Yoshio Shimada, Yutaka Ariki, Kazunori Hosoe, Masaji Kawatsu, Ikuo Katsumi, Takayoshi Hidaka, Kiyoshi Watanabe
  • Patent number: 5089516
    Abstract: A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: February 18, 1992
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Tadayoshi Shiraishi, Keiji Kameyama, Takeshi Domoto, Naohiro Imai, Yoshio Shimada, Yutaka Ariki, Kazunori Hosoe, Masaji Kawatsu, Ikuo Katsumi, Takayoshi Hidaka, Kiyoshi Watanabe
  • Patent number: 5057538
    Abstract: A hydroxystyrene derivative represented by the formula (I): ##STR1## Wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sub.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O--(R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 --(Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: October 15, 1991
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Tadayoshi Shiraishi, Keiji Kameyama, Takeshi Domoto, Naohiro Imai, Yoshio Shimada, Yutaka Ariki, Kazunoro Hosoe, Masaji Kawatsu, Ikuo Katsumi, Takayoshi Hidaka, Kiyoshi Watanabe
  • Patent number: 5017484
    Abstract: A process for preparing an optically active 3-chloro-1, 2-propanediol by employing microorganism which can selectively metabolize (R)- or (S)-3-chloro-1,2-propanediol. The decomposition rate of the substrate can be accelerated and the substrate concentration can be increased by adding a compound having SH group to the reaction solution.According to the process of the present invention, the optically active 3-chloro-1,2-propanediol can be easily prepared starting from low-cost (R,S)-3-chloro-1, 2-propanediol.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: May 21, 1991
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Yoshio Nakamura, Masahiro Ogura, Yoshio Shimada, Kiyoshi Watanabe, Hideyuki Takahashi
  • Patent number: 4971996
    Abstract: A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.
    Type: Grant
    Filed: November 10, 1988
    Date of Patent: November 20, 1990
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Tadayoshi Shiraishi, Keiji Kameyama, Takeshi Domoto, Naohiro Imai, Yoshio Shimada, Yutaka Ariki, Kazunori Hosoe, Masaji Kawatsu, Ikuo Katsumi, Takayoshi Hidaka, Kiyoshi Watanabe
  • Patent number: 4925969
    Abstract: Ethyl-.beta.-benzoyacrylate is reacted with an alkali metal salt of (S)-alanine or an alkali metal salt of N.sup.6 -trifluoroacetyl-L-lysine to form the corresponding Michael addition product, and not less than an equivalent amount of acid is added after completion of the Michael addition to prevent conversion of the (S,S) form of the product to the (R,S) form.
    Type: Grant
    Filed: March 16, 1989
    Date of Patent: May 15, 1990
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Satomi Takahashi, Yasuyoshi Ueda, Kazuhiko Yamada, Yukio Yamada, Takehiko Yamane, Yoshifumi Yanagita, Yoshio Shimada, Kiyoshi Watanabe, Michio Nomura, Takehisa Ohashi, Kenji Inoue
  • Patent number: 4898822
    Abstract: A process for preparing optically active indoline-2-carboxylic acid by an optical resolution, which comprises subjecting a racemic ester of (R,S)-indoline-2-carboxylic acid having the general formula [(R,S)-I] to the action of an enzyme or a microorganism having a stereo-selective esterase activity, which is capable of asymmetrically hydrolyzing the racemic ester [(R,S)-I] to give optically active indoline-2-carboxylic acid having the formula [II*] so as to produce the hydrolysis product, i.e. optically active indoline-2-carboxylic acid [II*] and an unreacted optically active ester of indoline-2-carboxylic acid having the general formula [I*], isolating each optically active form, and further, if necessary, hydrolyzing the obtained optically active ester [I*] to give an optical antipode of the acid [II*].According to the process of the present invention, optically active indoline-2-carboxylic acid with a high optical purity can be prepared in a simple process with a good yield.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: February 6, 1990
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Masanori Asada, Shigeki Hamaguchi, Hidetoshi Katsuki, Yoshio Nakamura, Hideyuki Takahashi, Kenji Takahara, Yoshio Shimada, Takehisa Ohashi, Kiyoshi Watanabe
  • Patent number: 4821115
    Abstract: A color hard copy apparatus converts an analog video signal of a still picture frame displayed on a color graphic display into binary video data to obtain a multicolor gradation picture. A single analog-to-digital converter samples the analog video signal a plurality of times at respectively different threshold levels, each threshold level being maintained constant during the sampling of the entire picture frame, to convert the analog video signal into corresponding binary video data. The binary video data are written in a picture memory at predetermined write-in addresses according to a predetermined multicolor gradation picture program, such as an organized dither program or a density pattern, and the binary video data are read out of the picture memory according to the predetermined multicolor gradation picture program to obtain binary picture data signals for use in printing a high-quality multicolor gradation picture corresponding to the desired picture frame displayed on the color graphic display.
    Type: Grant
    Filed: September 30, 1986
    Date of Patent: April 11, 1989
    Assignee: Seiko Instruments & Electronics Ltd.
    Inventors: Kenichi Matsushima, Fumihiro Tanaka, Kaneo Yamaguchi, Yoshio Shimada, Shinya Watanabe
  • Patent number: 4812406
    Abstract: A process for preparing optically active hydantoins having the general formula (II): ##STR1## wherein R.sup.1 and R.sup.2, which are different from each other, are independently alkyl group, aralkyl group, aryl group, substituted alkyl group, substituted aralkyl group, or substituted aryl group, or R.sup.1 and R.sup.2 form an asymmetric cyclic compound, characterized in that one configuration of racemic N-carbamoyl-.alpha.-amino acid having the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are as above, is enzymatically converted into the corresponding hydantoins.The present invention provides a process for an optical resolution with a high efficiency which can be used for the synthesis of (S)-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione (USAN; Sorbinil), which is an optically active hydrantoins attracting public attention as a preventive or a remedy for the particular chronic symptoms of diabetes such as cataract and neuropathy, and (S)-.alpha.
    Type: Grant
    Filed: September 12, 1985
    Date of Patent: March 14, 1989
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Satomi Takahashi, Yukio Yamada, Yasuyoshi Ueda, Yasuhiro Katayama, Yoshio Shimada, Kiyoshi Watanabe
  • Patent number: 4780759
    Abstract: A recording apparatus receives a video signal containing a horizontal sync signal and a data signal comprised of a given number of image bit data arranged within each horizontal scanning period, and stores the number of image bit data in synchronization with the horizontal sync signal. A voltage-controlled oscillator produces in synchronization with the horizontal sync signal a frequency signal having a frequency higher than that of the sync signal. A divider frequency-divides the frequency signal by a given factor to produce a number of sampling pulses corresponding to the given number of image bit data. A data sampling circuit receives the data signal for sampling therefrom the number of image bit data in response to the corresponding sampling pulses to thereby write the image bit data into memory. Another divider frequency-divides the frequency signal by the product of the given factor and the given number to produce a feedback signal.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: October 25, 1988
    Assignee: Seiko Instruments & Electronics Ltd.
    Inventors: Kenichi Matsushima, Fumihiro Tanaka, Yoshio Shimada, Kaneo Yamaguchi, Shinya Watanabe
  • Patent number: 4779140
    Abstract: A hard copy system regulatively processes a video signal with a settable regulatory parameter to produce regulated picture information which is reproducible as a hard copy. A multiplexer receives a plurality of video signals having different signal forms to selectively apply one of the video signals to the hard copy system. A memory stores a plurality of different regulatory parameters assigned to the respective video signals and determined according to the different signal forms thereof so as to optimize the regulative processing thereof. A controller operates when a selected video signal is processed for retrieving from the memory a regulatory parameter assigned to the selected video signal to set the retrieved regulatory parameter to thereby enable the hard copy system to produce optimally regulated picture information.
    Type: Grant
    Filed: September 30, 1986
    Date of Patent: October 18, 1988
    Assignee: Seiko Instruments & Electronics Ltd.
    Inventors: Kenichi Matsushima, Fumihiro Tanaka, Kaneo Yamaguchi, Yoshio Shimada, Shinya Watanabe
  • Patent number: 4713691
    Abstract: An interface circuit of video signal hard copy apparatus for optimizing a phase of a sampling clock to an image signal. A delayed signal of a video sync signal is employed for a reference input signal of a sampling clock generation circuit. The delay quantity of the video sync signal is arbitrarily set by a control circuit. The delay quantity corresponding to the point of change of sampled data is detected by a CPU circuit according to the sequential comparison with some of the sampled data of an image signal in the plural delay quantities. A stable sampling can be attained even for a high frequency video signal exceeding 100 MHz by setting the optimum delay quantity according to the detected delay quantity.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: December 15, 1987
    Assignee: Seiko Instruments & Electronics Ltd.
    Inventors: Fumihiro Tanaka, Yoshio Shimada, Kaneo Yamaguchi, Kenichi Matsushima, Shinya Watanabe
  • Patent number: 4713690
    Abstract: A sampling clock phase correction circuit of video signal to keep stably a phase of a sampling clock to an image signal. A delayed signal of a video sync signal is employed for a reference signal of a sampling clock generation circuit. The delay quantity of the video sync signal is controlled to sample stably the video image signal according to the comparison and discrimination of a phase relation between a sampling clock signal and a video sync signal by a phase detection circuit and a CPU circuit. A precise phase correction where a characteristic change of circuit elements by a temperature drift or the like is compensated can be attained even for a high frequency video signal exceeding 100 MHz.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: December 15, 1987
    Assignee: Seiko Instruments & Electronics Ltd.
    Inventors: Shinya Watanabe, Fumihiro Tanaka, Kaneo Yamaguchi, Yoshio Shimada, Kenichi Matsushima
  • Patent number: 4625042
    Abstract: The present invention relates to 3-(4-fluorophenoxy)propionitrile having the formula (I): ##STR1## a process for preparing 3-(4-fluorophenoxy)propionitrile having the formula (I) which comprises reacting 4-fluorophenol and acrylonitrile in the presence of a tertiary amine, a process for preparing 6-fluoro-4-chromanone having the formula (II): ##STR2## which comprises reacting 3-(4-fluorophenoxy)propionitrile having the formula (I) with an acid, and a process for preparing 6-fluoro-4-chromanone having the formula (II) which comprises reacting 4-fluorophenol with acrylonitrile in the presence of a catalyst to give 3-(4-fluorophenoxy)propionitrile having the formula (I), which is then reacted with an acid. 6-Fluoro-4-chromanone is an important intermediate for the synthesis of (S)-2,3-dihydro-6-fluoro-spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'di one (USAN: sorbinil).
    Type: Grant
    Filed: July 8, 1985
    Date of Patent: November 25, 1986
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Satomi Takahashi, Yasuyoshi Ueda, Yoshio Shimada, Kiyoshi Watanabe
  • Patent number: 4540992
    Abstract: A multicolored thermal transfer copying system needs an ink film having more than three colors successively. The accurate copying is performed by driving the plural platens via one metal roller, when plural thermal heads are used for transferring each color from the ink film.
    Type: Grant
    Filed: April 7, 1983
    Date of Patent: September 10, 1985
    Assignee: Kabushiki Kaisha Daini Seikosha
    Inventors: Murato Moteki, Yoshio Shimada, Fumihiro Tanaka, Fumio Watanabe, Kazuyuki Komatsu
  • Patent number: 4194065
    Abstract: A process is disclosed wherein yeast cells containing coenzyme Q in large quantities are efficiently produced by aerobically cultivating a yeast, in which maximum specific growth rate is not less than 0.15 hr.sup.-1 under optimum cultural conditions, in a nutrient medium in which said yeast can grow, while maintaining the dissolved oxygen concentration in the culture broth at not less than 2 ppm and controlling the average specific growth rate through the whole period of cultivation at not more than 0.1 hr.sup.-1, and coenzyme Q is recovered from the resulting yeast cells.
    Type: Grant
    Filed: October 18, 1977
    Date of Patent: March 18, 1980
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Yoshio Shimada, Keiichi Kagotani, Norio Noda, Hajime Kawaharada, Kiyoshi Watanabe