Patents by Inventor Yoshio Toyomaki

Yoshio Toyomaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kallikrein inhibitor substance, a process for preparation and pharmaceutical compositions thereof
    Patent number: 5057324
    Abstract: A physiologically active substance is extracted from infected tissues inoculated with a poxvirus. The novel substance of the present invention has inhibitory action against the formation of kallikrein, thus is useful as drugs such as antiinflammatory, analgesic and antiallergic agents.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: October 15, 1991
    Assignee: Nippon Zoki Pharmaceutical Co., Ltd.
    Inventors: Yoji Shibayama, Yoshio Toyomaki
  • Parabanic acid derivatives and pharmaceutical compositions thereof
    Patent number: 4985453
    Abstract: Parabanic acid compound of the formula (I): ##STR1## wherein R is hydrogen or a lower alkyl group, X is hydrogen, an alkyl group, a cycloalkyl group, a lower alkylcycloalkyl group, a phenyl group or a phenalkyl group, and n represents an integer of 1 to 4, exhibit excellent aldose reductase inhibitory activity and are useful as drugs for treating or prevention of complications of diabetes.
    Type: Grant
    Filed: July 26, 1989
    Date of Patent: January 15, 1991
    Assignee: Nippon Zoki Pharmaceutical Co., Ltd.
    Inventors: Akira Ishii, Masahiro Yamakawa, Yoshio Toyomaki
  • Method of assaying kallikrein formation substances
    Patent number: 4985354
    Abstract: A method of assaying a physiologically active substance, which comprises activating blood coagulation factor XII in plasma in the presence of said physiologically active substance being tested to convert prekallikrein in the plasma into kallikrein, and measuring the activity of kallikrein thus formed.
    Type: Grant
    Filed: September 10, 1987
    Date of Patent: January 15, 1991
    Assignee: Nippon Zoki Pharmaceutical Co., Ltd.
    Inventors: Yoshio Toyomaki, Katsumi Nishikawa, Hitoshi Kawakubo
  • Vincamine derivatives useful as cerebral metabolic and circulatory regulators
    Patent number: 4364947
    Abstract: This invention relates to novel vincamine derivatives useful as cerebral metabolic and circulatory regulators. The compounds have the following structural formula: ##STR1## wherein R.sub.1 is hydrogen or a hydroxyl group and R.sub.2 is an alkyl group.
    Type: Grant
    Filed: May 8, 1981
    Date of Patent: December 21, 1982
    Assignee: Nippon Zoki Pharmaceutical Co., Ltd.
    Inventor: Yoshio Toyomaki