Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Abstract: Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C1-C6 alkyl; R1 represents morpholino (which may be substituted with one to four C1-C6 alkyl); and R2 and R3 each represent hydrogen atom or C1-C6 alkyl.

Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Abstract: Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C1-C6 alkyl; R1 represents morpholino (which may be substituted with one to four C1-C6 alkyl); and R2 and R3 each represent hydrogen atom or C1-C6 alkyl.

Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Abstract: The present application describes a method of treating prostate cancer, melanoma or hepatic cancer in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of the heterocyclic compound represented by Formula I or its pharmaceutically acceptable salt:

Abstract: The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen atom, hydroxyl or amino; R3 represents morpholino (which may be substituted with one or two C1–C6 alkyl), pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl) or NR6R7 [R6 represents C1–C6 alkyl and R7 represents piperidinyl (which may be substituted with C1–C6 alkyl)]; R4 and R5 each represents hydrogen atom or C1–C6 alkyl, with the proviso that R2 is hydrogen atom and R3 is pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl) when R1 is hydroxyl

Abstract: The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen atom, hydroxyl or amino; R3 represents morpholino (which may be substituted with one or two C1-C6 alkyl), pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl) or NR6R7 [R6 represents C1-C6 alkyl and R7 represents piperidinyl (which may be substituted with C1-C6 alkyl)]; R4 and R5 each represents hydrogen atom or C1-C6 alkyl, with the proviso that R2 is hydrogen atom and R3 is pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl) when R1 is hydroxyl

Abstract: The present invention provides an alerting tone that daily life noises cannot mask, and that is therefore optimum to both young and elderly people. Through specifying various household activities performed in a home, measuring and analyzing frequency of the relevant operating noises (daily life noises) and quantitatively defining the actual status of background noises in a home where electric appliances are being used, alerting devices output an alerting tone having a predominant frequency substantially in a range lower than 3 kHz but not lower than 1.5 kHz, as an alerting tone designed in consideration of the daily life noises, and having the optimum frequency and sounding pattern for various apparatus.

Abstract: Contents are supplied from a studio to a plant through a CD-R disc. In the plant, when it is determined that the contents have not been encrypted in accordance with Info_Sheet, a module encrypts the contents with different keys. A key locker creating portion groups the plurality of keys with which the contents have been encrypted, encrypts grouped keys with a disc key, and creates a key locker. A disc image creating portion creates image data to be recorded on a product CD with contents of a first session and a second session and the key locker. In accordance with the image data, the CD is produced. Since keys with which contents have been encrypted are grouped and encrypted, the keys can be prevented from leaking out.

Abstract: An antibacterial compound wherein represents benzene ring, pyridine ring, pyrazine ring or 5-membered aromatic neterocycle (having one oxygen or sulfur atom as ring-constituting atom), there being no R4 where  represents 5-membered aromatic heterocycle; X and Y respectively represent hydrogen atom or CXY represents C═N—OR5 wherein R5 represents hydrogen atom, halo C1-C6 alkyl or C3-C7 cycloalkyl; R1 represents phenyl, furyl, thienyl, thiazolyl (which may be substituted by amino group), tetrazolyl or thiadiazolyl, R2, R3 and R4 respectively represent hydrogen atom, halogen, hydroxyl group, nitro, C1-C6 alkoxy, trifluoromethyl, isothiuronium C1-C6 alkyl, amino C1-C6 alkyl, halo C1-C6 alkyl, morpholino, piperidino or piperazinyl.

Abstract: s-Triazine (1,3,5-triazine) is chemically modified to obtain s-triazine derivative effective for prevention and treatment of estrogen-dependent diseases.

Abstract: An axially centering apparatus for fusion-bonding optical fibers comprising a pair of guides having long grooves on the upper surfaces thereof for engaging optical fibers, a pair of fulcra formed in parallel with the long grooves of the guides for supporting the guides, a pair of centering stands having substrates for supporting the fulcra, a pair of centering mechanisms having load imparting mechanism sections having telescopic output ends, load imparting mechanism sections, and transmitting mechanism sections for the adjusting mechanism sections so that the long grooves of said centering stands are disposed adjacent to each other to align in a rectilinear line, said centering mechanisms are associated with the centering stands to contact the output ends of the centering mechanisms with the guides of the centering stands, wherein said one centering stand satisfies the conditions that the fulcrum 3A and the long groove 4A are relatively positioned so that the crossing angle .alpha.

Abstract: A pair of guides having long grooves on the upper surfaces thereof for engaging optical fibers, a pair of fulcra formed in parallel with the long grooves of the guides for supporting the guides, a pair of centering stands having substrates for supporting the fulcra, a pair of centering mechanisms having load imparting mechanism sections having telescopic output ends, load imparting mechanism sections, and transmitting mechanism sections for the adjusting mechanism sections so that the long grooves of said centering stands are disposed adjacent to each other to align in a rectilinear line. The centering mechanisms are associated with the centering stands to contact the output ends of the centering mechanisms with the guides of the centering stands.

Abstract: An image signal encoding system wherein image signal is directly taken in through video camera, changed to digital data, broken down into PDI basic patterns, and then converted into NAPLPS code automatically. The taken-in image signal is divided into a plurality of areas and the information amount of the image signal is reduced for adequate encoding after taking in the image signal. Usually "POLYGON" command is used as the NAPLPS code.