Abstract: The present invention provides methods of inhibiting or sequestering 14-3-3 protein from binding to the insulin receptor substrate −1 or −2 by administering a substance which inhibits the interaction of these two proteins.

Abstract: The present invention relates to a remedy for diseases caused by insulin resistance, which comprises, as an active ingredient, a substance exhibiting activity for inhibiting the binding of the full-length insulin receptor substrate-1 (IRS-1) or insulin receptor substrate-2 (IRS-2) or a portion of the same to the full-length 14-3-3 protein or a portion of the same; and to a screening method for a remedy for diseases caused by insulin resistance, which comprises assaying the activity for inhibiting the binding.

Abstract: There is provided a mouse lacking the function of the endotheline-1 gene by insertion of another gene into the endotheline-1 gene.The mouse is useful for elucidation of the pathological physiology and causes of and development of therapies for cardiovascular diseases such as hypertension, arteriosclerosis and ischemic heart disease.

Abstract: Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500.+-.300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S--S bond.In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium.The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.

Abstract: A diagnostic agent for heart disease comprising a radiolabeled monoclonal antibody having specificity to cardiac myosin heavy chain or its active fragment is disclosed. The diagnostic agent is useful for topographic diagnosis of heart disease such as myocardial infarction and myocardial disease by imaging.

Abstract: Disclosed are an annular light source unit using electrodeless discharge and a method of lighting the same. The unit comprises an annular electrodeless discharge tube, a bowl-shaped microwave cavity device, and a plurality of microwave oscillators. The cavity unit is disposed in such a manner as to cover substantially the whole outer surface of the discharge tube excluding an underside thereof. The unit has slit antennas at a plurality of portions thereof prepared by dividing into substantially equal parts a whole circumferential portion thereof facing a whole circumferential surface of the discharge tube. The method comprises the step of individually sequentially starting the operations of the microwave oscillators after the stabilization of the discharge at a portion of the discharge tube in the vicinity of the corresponding slit antenna due to supply, therefrom, of microwave powers transmitted from the immediately preceding microwave oscillator.

Abstract: A monoclonal antibody having specificity to an isozyme of cardiac myosin heavy chain. The monoclonal antibody is useful as a reagent important for biochemical and pathological researches relating to cardiac muscles and diagnosis of myocardial infarction.

Abstract: Disclosed is a transfer type each-side exposure apparatus which comprises light sources which oppose each other and transfer means which transfer materials to be exposed between the light sources. In one aspect, the apparatus further comprises light shielding means which prevent the passage of the light rays for irradiation as required, and control means which controls the actuation of the light shielding means. In another aspect, the apparatus further comprises reflectors which consist each of a cold mirror. In still another aspect, the apparatus is such that the light sources are each disposed in a manner that a cathode constituting its light emitting portion is displaced by a small distance from one of focal points of a corresponding reflector provided in the light source.

Abstract: In an exposure device, the light rays emitted from a light source and radiated at an illumination surface, the light rays directly incident to the illuminated surface, the light rays incident to the illuminated surface at greater angles of incidents and the light rays which cause the overexposure of the object to be exposed are interrupted by an optical shielding plate interposed between the light source and the illuminated surface so that the unwanted light rays can be cut-off.The illuminated surface has a specific illumination distribution pattern inherent to the light source used so that the integrated quantities of light rays each incident to each point on the surface of the object to be exposed do not become uniform.

Abstract: A movable light-source type exposure apparatus comprising a light source disposed at the focal point of a parabolic reflector, a first light-shielding member disposed right beneath the light source and intended to prevent the light rays from the light source from being irradiated directly over a mask and a work, a second light-shielding member disposed closely to the mask and work so as to cause the formation of a shadow capable of equalizing the cumulated amounts of light rays at points thereon, a positioning/fixing means intended, for each exposure, to position and fix a retaining frame for the mask and a retaining frame for the work, and a light-source moving means for moving a lamp house having the parabolic reflector, light source, first light-shielding member and second shielding member over the mask and work for purpose of causing the same to be exposed.

Abstract: At least one strip of dry film assembly is supplied continuously to a plurality of mutually spaced apart boards which are also being fed continuously. The film assembly consists of a photosensitive layer sandwiched between a protective film and a base. The base is removed from the assembly when the assembly is supplied to the boards, so that each of the boards may be bonded to the photosensitive layer. The boards and the film assembly are fed intermittently, and the photosensitive layer is exposed to light to print a predetermined pattern on each board. The protective film is removed from the film assembly, and each printed board is subjected to developing treatment.

Abstract: An exposure apparatus comprises a fly eye lens through which the light beam from a light source condensed by a first optical system is supplied to a second optical system which collimates the light to direct it to a work through a mask pattern so that the pattern is printed on the work, the fly eye lens being rotated to uniform the distribution of illuminance so that a clear printed pattern is formed on the work without interference fringes.

Abstract: A printing apparatus for exposing works, such as printed circuit boards, to light uses a pallet in which a number of works and at least one associated mask are stored. The works are located in stacked relation to one another. The mask is located above the works. The printing apparatus comprises an exposure device including light sources and transparent plates, an admitting device for holding the pallet in an access position and for holding the uppermost one of the mask and works in the pallet at a certain height, a conveying device including a rail extending from the access position to a takeout position past an exposure position at which an exposure operation is performed, and an attraction device including attraction plates having a number of attraction pads mounted to the underside thereof for attracting and holding the mask and works. Each attraction plate is vertically movable while keeping a horizontal posture.

Abstract: An ultraviolet ray projector comprises a reflector; a mercury lamp disposed in the reflector; a casing having one opening port which receives the reflector and the mercury lamp; a holder connected on an outer wall of the casing.The opening port of the casing has a shielding mechanism for controlling diffusion of ultraviolet rays.