Abstract: There is provided an FGF2 substitute-containing medicinal composition which comprises, as an active ingredient, a chimeric protein comprising the amino acid sequence of an FGF1 protein in which a partial sequence including a sequence of at least positions 62-83 within a sequence of positions 41-83 is substituted with a partial sequence at the corresponding positions in the amino acid sequence of an FGF2 protein; and the remaining region is formed of the amino acid sequence of FGF1. In particular, this medicinal composition is used for wound healing and for the prevention and treatment of radiation-induced damage, and it exhibits a pharmacological action superior to that of an FGF2 medicinal composition, and further, it can be easily formulated into a preparation.

Abstract: There is provided an FGF2 substitute containing medicinal composition which comprises, as an active ingredient, a chimeric protein comprising the amino acid sequence of an FGF1 protein in which a partial sequence including a sequence of at least positions 62-83 within a sequence of positions 41-83 is substituted with a partial sequence at the corresponding positions in the amino acid sequence of an FGF2 protein; and the remaining region is formed of the amino acid sequence of FGF1. In particular, this medicinal composition is used for wound healing and for the prevention and treatment of radiation-induced damage, and it exhibits a pharmacological action superior to that of an FGF2 medicinal composition, and further, it can be easily formulated into a preparation.

Abstract: A monitor protein for measuring the expression of a membrane protein on a cell membrane is provided. The monitor protein includes a fusion protein in which the membrane protein and a luminescence protein are linked. Also provided are a DNA encoding the monitor protein; an expression vector for the DNA; a cell expressing the vector; a method of detection/quantitative determination of the monitor protein; and a method of measuring the inhibitory or promotive activity of a test substance against the expression of a membrane protein on the cell membrane or the intracellular transport of a membrane protein.

Abstract: The invention relates to a method and apparatus for freezing a sample by solidifying a liquid contained in the sample and widen the distance within the sample where the same is amorphously solidified. For this purpose, the sample is cooled immediately after being irradiated with an electromagnetic wave. The apparatus includes an electromagnetic irradiating means for irradiatine an electromagnetic wave on a sample immediately before freezing thereof.