Patents by Inventor Yoshiro Ishimaru

Yoshiro Ishimaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for screening saltiness enhancer using saltiness receptor
    Patent number: 11547102
    Abstract: A method for screening an active ingredient of a saltiness enhancer, the screening method including the following steps: (i) a step for determining whether a test substance is a compound capable of promoting functional expression of the TMC4 gene or TMC4 protein; and (ii) a step for selecting, as an active ingredient of a saltiness enhancer, a test substance that has been determined in step (i) to be a compound capable of promoting functional expression of the TMC4 gene or TMC4 protein.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: January 10, 2023
    Assignees: NISSIN FOODS HOLDINGS CO., LTD., THE UNIVERSITY OF TOKYO
    Inventors: Yoichi Kasahara, Tomiko Asakura, Keiko Abe, Yoshiro Ishimaru, Masataka Narukawa
  • METHOD FOR SCREENING SALTINESS ENHANCER USING SALTINESS RECEPTOR
    Publication number: 20210360907
    Abstract: A method for screening an active ingredient of a saltiness enhancer, the screening method including the following steps: (i) a step for determining whether a test substance is a compound capable of promoting functional expression of the TMC4 gene or TMC4 protein; and (ii) a step for selecting, as an active ingredient of a saltiness enhancer, a test substance that has been determined in step (i) to be a compound capable of promoting functional expression of the TMC4 gene or TMC4 protein.
    Type: Application
    Filed: December 27, 2018
    Publication date: November 25, 2021
    Applicants: NISSIN FOODS HOLDINGS CO., LTD., THE UNIVERSITY OF TOKYO
    Inventors: Yoichi KASAHARA, Tomiko ASAKURA, Keiko ABE, Yoshiro ISHIMARU, Masataka NARUKAWA
  • Methods of identifying ligands to sour-taste receptors comprising PKD1L3 and PKDPKD2L1
    Patent number: 8512965
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: August 20, 2013
    Assignee: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • CELL LINES COMPRISING SOUR-TASTE RECEPTORS
    Publication number: 20120322084
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Application
    Filed: August 21, 2012
    Publication date: December 20, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • CELL LINES COMPRISING SOUR-TASTE RECEPTORS
    Publication number: 20110311986
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Application
    Filed: August 22, 2011
    Publication date: December 22, 2011
    Applicant: DUKE UNIVERSITY
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • Cell lines comprising sour-taste receptors
    Patent number: 8003384
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: August 23, 2011
    Assignee: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • SOUR TASTE RECEPTOR COMPOSITIONS AND METHODS
    Publication number: 20100136602
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Application
    Filed: December 7, 2009
    Publication date: June 3, 2010
    Applicant: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • Sour taste receptor compositions and methods
    Patent number: 7629134
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: December 8, 2009
    Assignee: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • Sour taste receptor compositions and methods
    Publication number: 20080081345
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Application
    Filed: July 10, 2007
    Publication date: April 3, 2008
    Applicant: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru