Abstract: Provided is a guide device including a cylindrical insertion part that is inserted into a body and that opens near a distal end thereof and on a proximal side thereof, a perforating part that is disposed at the distal end of the insertion part and that perforates tissue, a moving part disposed near the distal end of the insertion part so as to be displaceable between a nearby position near the insertion part and a farther position farther away from the insertion part than the nearby position, a biasing mechanism that biases the moving part in a direction away from the insertion part, and a displacement-detecting mechanism that detects displacement of the moving part in the body.

Abstract: Therapeutic solution of an amount corresponding to a plurality of injections is injected with the distal end kept inserted in the pericardial cavity via an access port formed to penetrate under the xiphoid process. Provided is a therapeutic-solution injecting device (1) including an injection needle (3) for puncturing living tissue; a tube (6) having the injection needle (3) at a distal end thereof; a syringe connector (5) provided at a proximal end of the tube (6) and allowing connection and disconnection of a therapeutic-solution syringe (4) containing therapeutic solution; and a three-way valve (8) provided in the tube (6) between the syringe connector (5) and the injection needle (3) and having an open end.

Abstract: A procedure of positioning a treatment part at various sites on an organ is facilitated, and the positioning thereof can be stably maintained for treatment with accurate positioning. A treatment instrument includes a rigid rod-shaped insertion section having a treatment part at a distal end thereof and a manipulating section secured to a proximal end of the insertion section and gripped and manipulated by an operator. The insertion section includes a main body extending in a straight line, a first curved portion disposed at a distal end of the main body and curved in one direction with respect to the main body, and a second curved portion disposed on a distal side of the first curved portion and curved in a direction opposite to the direction in which the first curved portion is curved. The treatment part is inclined with respect to the longitudinal axis of the main body.

Abstract: In a pericardioscopic procedure, without providing an endoscope or surgical instrument with special space ensuring means and without unnecessarily dilating the pericardial space, a space necessary for operation of the endoscope or surgical instrument is ensured, so that maneuverability is improved while suppressing complications. Provided is a space ensuring device comprising: a pericardium pressing part for pressing a pericardium from the pericardial space side; a heart pressing part for pressing the surface of a heart from the pericardial space side; and an interconnecting part interconnecting the pericardium pressing part and the heart pressing part, wherein the interconnecting part generates the resilient force enabling expansion against a pressure applied by a pericardium and a heart so as to ensure a space between the pericardium pressing part and the heart pressing part.

Abstract: It is an object to provide an endoscopic heart surgery method with which it is possible to observe an endoscopic image with a stable field of view in the pericardial space. Provided is an endoscopic heart surgery method including an inserting step of inserting an inserted portion of an endoscope into a body from the subxiphoid area and inserting the inserted portion into the pericardial space by penetrating the pericardium in the vicinity of the heart apex; a moving step of advancing the inserted portion toward the base of the heart so that the inserted portion passes through the vicinity of the roof of the pericardial space and is moved toward the heart apex to a treated area in the pericardial space; and an observing step of observing the treated area with the endoscope.

Abstract: It is an object to provide an endoscopic heart surgery method with which it is possible to observe an endoscopic image with a stable field of view in the pericardial space. Provided is an endoscopic heart surgery method including an inserting step of inserting an inserted portion of an endoscope into a body from the subxiphoid area and inserting the inserted portion into the pericardial space by penetrating the pericardium in the vicinity of the heart apex; a moving step of advancing the inserted portion toward the base of the heart so that the inserted portion passes through the roof of the pericardial space and is moved toward the heart apex to a treated area in the pericardial space; and an observing step of observing the treated area with the endoscope.

Abstract: With an endoscope including a long, thin inserted portion that is inserted into the body of a patient, securing means for securing the inserted portion to tissue inside the body, the securing means being provided at least at a distal-end portion of the inserted portion, an observation optical system that is provided at the inserted portion and that acquires an image of the tissue, and observation-distance adjusting means for adjusting the distance between the observation optical system and a surface of the tissue, it is possible to attain a stable field of view without having to stop the pulsation or the like of the heart or other tissue.

Abstract: A fragrance composition which contains 1,3-dimethoxy-5-methylbenzene in an amount of from 0.01 to 30% by weight as a fragrance modifier that provides a sedative effect. 1,3-Dimethoxy-5-methylbenzene used in the present invention can exhibit a sedative effect not only by itself but also when mixed with various formulations of jasmine, floral and the like types having stimulative effects. Also, since a single chemical is used as an active ingredient, the present invention is more effective than the sedative function of natural essential oil from a viewpoint of sedation. In addition, since 1,3-dimethoxy-5-methylbenzene itself has a mild scent, its sedative effect can be obtained without altering original fragrance of interest.