Patents by Inventor Yoshisuke Machida

Yoshisuke Machida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (1R,5S,6S)-2-[(6,7-dih ydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]- 1-methyl-carbapenem-3-carboxylate and intermediate therefor
    Patent number: 4990613
    Abstract: (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[(1,2-diiminomethyl)-4-pyrazol idinyl-thio-carbapenem-3-carboxylic acid is provided as an intermediate, which is converted into (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl]thio-6 -[R-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate. This compound is an antibacterial agent, which also may be in the form of the corresponding acid or pharmaceutically acceptable salt, in which case there is included an anionic group balancing the traizolinium positive charge. As such as anionic group may be mentioned, for example, the chloride, acatate or carbonate. As the salt may be mentioned the alkali metal salts, for example, sodium.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: February 5, 1991
    Assignee: Lederle (Japan), Ltd.
    Inventors: Toshi Kumagai, Hiroshi Matsunaga, Yoshisuke Machida, Yunosuke Nagase, Muneo Hikida, Yoshimitsu Nagao
  • Antibacterially effective methods and compositions based upon (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thi o-6-[R-1-hydroxyethyl]-1-methyl-carbapenem-3-caroxylate and salts therefore
    Patent number: 4925836
    Abstract: Methods and compositions are provided for controlling or preventing a bacterial infection which are based upon (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio- 6-[R-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: May 15, 1990
    Assignee: Lederle (Japan), Ltd.
    Inventors: Toshio Kumagai, Hiroshi Matsunaga, Yoshisuke Machida, Yunosuke Nagase, Muneo Hikida, Yoshimitsu Nagao
  • Methods for the manufacture of (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl]thio -6-[R-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate
    Patent number: 4925935
    Abstract: (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[(1,2-diiminomethyl)-4-pyrazol idinyl]-thio-carbapenem-3-carboxylic acid is provided as an intermediate, which is converted into (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio- 6-[R-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate. This compound is an antibacterial agent, which also may be in the form of the corresponding acid or pharmaceutically acceptable salt, in which case there is included an anionic group balancing the traizolinium positive charge. As such an anionic group may be mentioned, for example, the chloride, acatate or carbonate. As the salt may be mentioned the alkali metal salts, for example, sodium.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: May 15, 1990
    Assignee: Lederle (Japan), Ltd.
    Inventors: Toshio Kumagai, Hiroshi Matsunaga, Yoshisuke Machida, Yunosuke Nagase, Muneo Hikida, Yoshimitsu Nagao
  • (1R,5S,6S)-2-[(6,7-dihydr o-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-m ethyl-carbapenum-3-carboxylate
    Patent number: 4866171
    Abstract: (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[(1,2-diiminomethyl)-4-pyrazol idinyl]-thio-carbapenum-3-carboxylic acid is provided as an intermediate, which is converted into (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio- 6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate. This compound is an antibacterial agent, which also may be in the form of the corresponding acid or pharmaceutically acceptable salt, in which case there is included an anionic group balancing the traizolinium positive charge. As such an anionic group may be mentioned, for example, the chloride, acatate or carbonate. As the salt may be mentioned the alkali metal salts, for example, sodium.
    Type: Grant
    Filed: December 8, 1987
    Date of Patent: September 12, 1989
    Assignee: Lederle (Japan), Ltd.
    Inventors: Toshio Kumagai, Hiroshi Matsunaga, Yoshisuke Machida, Yunosuke Nagase, Muneo Hikida, Yoshimitsu Nagao