Patents by Inventor Yoshitaka Isaka

Yoshitaka Isaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240127956
    Abstract: Provided herein is a method for providing information about virus infection and/or virus infection disease in a subject, comprising: making a determination on the detection and/or stage classification of virus infection and/or virus infection disease in the subject using an indicator associated with a D-amino acid in the subject; and providing information about virus infection and/or virus infection disease in the subject based on the results of the determination.
    Type: Application
    Filed: October 17, 2023
    Publication date: April 18, 2024
    Applicants: Osaka University, National Institutes of Biomedical Innovation, Health and Nutrition, Kagami Inc.
    Inventors: Yoshitaka ISAKA, Tomonori KIMURA, Shihoko KIMURA, Masashi MITA
  • Publication number: 20220003774
    Abstract: The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.
    Type: Application
    Filed: July 13, 2021
    Publication date: January 6, 2022
    Applicants: Osaka University, Kagami Inc.
    Inventors: Yoshitaka ISAKA, Tomonori KIMURA, Keiko YASUDA, Kenji Hamase, Masashi MITA
  • Patent number: 11099191
    Abstract: The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: August 24, 2021
    Assignees: Osaka University, Kagami Inc.
    Inventors: Yoshitaka Isaka, Tomonori Kimura, Keiko Yasuda, Kenji Hamase, Masashi Mita
  • Publication number: 20190317106
    Abstract: The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.
    Type: Application
    Filed: May 17, 2017
    Publication date: October 17, 2019
    Applicants: Osaka University, Shiseido Company, Ltd.
    Inventors: Yoshitaka Isaka, Tomonori Kimura, Keiko Yasuda, Kenji Hamase, Masashi Mita
  • Publication number: 20190271708
    Abstract: The purpose of the present invention is to provide: a blood sample analysis method for determining diabetes complications in subjects with kidney damage on the basis of D- and L-amino acid content, from a blood sample; a method for examining diabetes complications; and a sample analysis system that outputs pathological information about diabetes complications. The purpose of this invention is achieved by using at least one amino acid selected from the group consisting of D-aspartic acid, D-proline, L-glutamine, and L-isoleucine, in order to determine diabetes complications.
    Type: Application
    Filed: May 17, 2017
    Publication date: September 5, 2019
    Applicants: Osaka University, Shiseido Company, Ltd.
    Inventors: Yoshitaka Isaka, Tomonori Kimura, Keiko Yasuda, Kenji Hamase, Masashi Mita
  • Publication number: 20140147936
    Abstract: The present invention relates to a method for determining the prognosis of renal failure, which comprises measuring fibroblast growth factor-23 and 25-hydroxyvitamin D in a biological sample, and a kit for determining the prognosis of renal failure, which comprises a reagent for measuring fibroblast growth factor-23 and a reagent for measuring 25-hydroxyvitamin D The present invention provides a method for determining the prognosis of renal failure and a kit for determining the prognosis of renal failure, which are useful for deciding on a therapeutic strategy, such as selection of medication, introduction of a stricter diet therapy, and early introduction of dialysis treatment.
    Type: Application
    Filed: April 23, 2012
    Publication date: May 29, 2014
    Applicant: Kyowa Medex Co., Ltd.
    Inventors: Takayuki Hamano, Yoshitaka Isaka, Isao Matsui
  • Patent number: 8592159
    Abstract: A process for detecting presumed IgA nephropathy by detection of Treponema bacteria and/or Campylobacter bacteria present in a sample from the tonsil of a subject who, optionally, has a positive result in a urinary protein test and/or a urinary occult blood test, or whom is diagnosed with possible IgA nephropathy. Also, a process for detecting an IgA nephropathy patient for whom tonsillectomy is effective by detecting Treponema bacteria or Campylobacter bacteria.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: November 26, 2013
    Assignee: Osaka University
    Inventors: Yasuyuki Nagasawa, Kenichiro Iio, Yoshitaka Isaka, Shinji Fukuda, Hiroshi Ohno
  • Patent number: 8263756
    Abstract: The present invention provides a method for gene transfer through the vascular system or a ureter. In a preferable embodiment of this invention, an aqueous solution containing an expression vector comprising a desired gene is injected through the vascular system or a ureter of a desired organ to introduce the gene into the injected area. Specifically, the method of the present invention is effective for ex vivo gene therapy wherein the hepatocyte growth factor (HGF) gene is introduced by electroporation into a kidney to be transplanted. According to the present invention, the HGF functions continuously on the kidney to be transplanted, and the HGF within the treated area does not affect other organs of the body. Thus, the method of the present invention is a safe and effective treatment for maintaining the survival of transplanted kidneys.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: September 11, 2012
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiro Takahara, Enyu Imai, Yoshitaka Isaka
  • Publication number: 20120034611
    Abstract: Based on detection of Treponema bacteria or Campylobacter bacteria present in a sample derived from the tonsil of a subject who has a positive result on at least one of a urinary protein test and a urinary occult blood test, or of a patient diagnosed with possible IgA nephropathy, presumed IgA nephropathy can be detected with a high accuracy, in a simple and quick manner without physical burden on subjects. Also, an IgA nephropathy patient for whom tonsillectomy is effective in therapy of IgA nephropathy can be selected with a high accuracy, in a simple and quick manner without physical burden on subjects.
    Type: Application
    Filed: February 10, 2010
    Publication date: February 9, 2012
    Applicant: OSAKA UNIVERSITY
    Inventors: Yasuyuki Nagasawa, Kenichiro Ito, Yoshitaka Isaka, Shinji Fukuda, Hiroshi Ohno
  • Publication number: 20040175370
    Abstract: The present invention provides a method for gene transfer through the vascular system or a ureter. In a preferable embodiment of this invention, an aqueous solution containing an expression vector comprising a desired gene is injected through the vascular system or a ureter of a desired organ to introduce the gene into the injected area. Specifically, the method of the present invention is effective for ex vivo gene therapy wherein the hepatocyte growth factor (HGF) gene is introduced by electroporation into a kidney to be transplanted. According to the present invention, the HGF functions continuously on the kidney to be transplanted, and the HGF within the treated area does not affect other organs of the body. Thus, the method of the present invention is a safe and effective treatment for maintaining the survival of transplanted kidneys.
    Type: Application
    Filed: April 23, 2004
    Publication date: September 9, 2004
    Inventors: Shiro Takahara, Enyu Imai, Yoshitaka Isaka
  • Publication number: 20030170897
    Abstract: The present invention provides a viral vector that ensures highly efficient gene transfer into renal cells and its use. The use of a Paramyxovirus vector enables gene transfer into renal cells with high efficiency. The gene transferred by in vivo administration can be continuously expressed in the renal cells over a prolonged period. The vector of the present invention is suitably used in gene therapy for kidney.
    Type: Application
    Filed: April 10, 2003
    Publication date: September 11, 2003
    Inventors: Enyu Imai, Yoshitaka Isaka, Masayuki Fukumura, Mamoru Hasegawa