Abstract: An advantage of the present invention is to suppress an increase in resistance during high-rate charge and discharge and a reduction in capacity during a charge and discharge cycle. An electrical storage module of the present embodiment includes: an electrical storage device, and an elastic body that is placed with the electrical storage device and receives a load from the electrical storage device in a placement direction. The electrical storage device includes a positive electrode, a negative electrode, and a separator. The negative electrode includes a negative-electrode active material layer. The negative-electrode active material layer includes a first layer formed on the negative-electrode current collector, and a second layer that is formed on the first layer and has a higher compression modulus than the first layer. The separator has a lower compression modulus than the first layer, and the elastic body has a lower compression modulus than the separator.

Abstract: Provided is an all-solid-state battery configured to suppress the collapse of an end in the plane direction of an electrode laminate. Disclosed is an all-solid-state battery comprising an electrode laminate that comprises a cathode comprising a cathode layer, an anode comprising an anode layer, and a solid electrolyte layer disposed between the cathode layer and the anode layer, wherein a resin layer containing a polymer is disposed in at least a part of an end in a plane direction of the electrode laminate, the polymer having a self-healing function and a structure crosslinked via bonding between a host molecule and a guest molecule.

Abstract: To provide a separator for all-solid-state batteries, which is configured to achieve both increased tensile strength and excellent ion conductivity, a method for producing the same, and an all-solid-state battery comprising the separator for all-solid-state batteries. Disclosed is a separator for all-solid-state batteries, the separator comprising a first solid electrolyte layer comprising a solid electrolyte and a hydrogenated rubber-based resin where a content of the hydrogenated rubber-based resin in the first solid electrolyte layer is 15% by volume or more and 30% by volume or less, and the separator optionally further comprising, on at least one surface of the first solid electrolyte layer, a second solid electrolyte layer comprising a solid electrolyte and a hydrogenated rubber-based resin where a content of the hydrogenated rubber-based resin in the second solid electrolyte layer is 0.1% by volume or more and less than 15% by volume.

Abstract: An advantage of the present invention is to suppress an increase in resistance during high-rate charge and discharge and a reduction in capacity during a charge and discharge cycle. An electrical storage module of the present embodiment includes: an electrical storage device, and an elastic body that is placed with the electrical storage device and receives a load from the electrical storage device in a placement direction. The electrical storage device includes a positive electrode, a negative electrode, and a separator. The negative electrode includes a negative-electrode active material layer. The negative-electrode active material layer includes a first layer formed on the negative-electrode current collector, and a second layer that is formed on the first layer and has a higher compression modulus than the first layer. The separator has a lower compression modulus than the first layer, and the elastic body has a lower compression modulus than the separator.

Abstract: A solid electrolyte laminate which can prevent a reduction in the discharge capacity of an all-solid-state battery despite the inclusion of an insulator such as alumina in the solid electrolyte laminate is disclosed. The disclosed solid electrolyte laminate includes a solid electrolyte and an insulator, wherein the solid electrolyte laminate has a multi-layer structure including a first low-insulator-content solid electrolyte layer, a high-insulator-content solid electrolyte layer, and a second low-insulator-content solid electrolyte layer laminated in this order. The content ratio of the insulator in each of the first and the second low-insulator-content solid electrolyte layer is lower than the content ratio of the insulator in the high-insulator-content solid electrolyte layer.

Abstract: Provided is an all-solid-state battery configured to suppress the collapse of an end in the plane direction of an electrode laminate. Disclosed is an all-solid-state battery comprising an electrode laminate that comprises a cathode comprising a cathode layer, an anode comprising an anode layer, and a solid electrolyte layer disposed between the cathode layer and the anode layer, wherein a resin layer containing a polymer is disposed in at least a part of an end in a plane direction of the electrode laminate, the polymer having a self-healing function and a structure crosslinked via bonding between a host molecule and a guest molecule.

Abstract: A main object of the present disclosure is to provide an all solid state battery in which both the improvement of uniformity of electrode reaction in a power generating element and inhibition of degrading in energy density are achieved.

Abstract: To provide a separator for all-solid-state batteries, which is configured to achieve both increased tensile strength and excellent ion conductivity, a method for producing the same, and an all-solid-state battery comprising the separator for all-solid-state batteries. Disclosed is a separator for all-solid-state batteries, the separator comprising a first solid electrolyte layer comprising a solid electrolyte and a hydrogenated rubber-based resin where a content of the hydrogenated rubber-based resin in the first solid electrolyte layer is 15% by volume or more and 30% by volume or less, and the separator optionally further comprising, on at least one surface of the first solid electrolyte layer, a second solid electrolyte layer comprising a solid electrolyte and a hydrogenated rubber-based resin where a content of the hydrogenated rubber-based resin in the second solid electrolyte layer is 0.1% by volume or more and less than 15% by volume.

Abstract: A solid electrolyte laminate which can prevent a reduction in the discharge capacity of an all-solid-state battery despite the inclusion of an insulator such as alumina in the solid electrolyte laminate is disclosed. The disclosed solid electrolyte laminate includes a solid electrolyte and an insulator, wherein the solid electrolyte laminate has a multi-layer structure including a first low-insulator-content solid electrolyte layer, a high-insulator-content solid electrolyte layer, and a second low-insulator-content solid electrolyte layer laminated in this order. The content ratio of the insulator in each of the first and the second low-insulator-content solid electrolyte layer is lower than the content ratio of the insulator in the high-insulator-content solid electrolyte layer.

Abstract: It is intended to provide a CAPRIN-1-targeting antibody superior in antitumor activity to conventional antibodies, and use thereof as a therapeutic and/or preventive agent for a cancer. The present invention provides an antibody targeting a CAPRIN-1 polypeptide specifically expressed on the surface of cancer cells, and use of the antibody as a therapeutic and/or preventive agent for a cancer. The present invention provides an antibody which comprises a heavy chain variable region comprising complementarity-determining regions of SEQ ID NOs: 1, 2, and 3 and a light chain variable region comprising complementarity-determining regions of SEQ ID NOs: 4, 5, and 6 and has immunological reactivity with a CAPRIN-1 protein, or a fragment thereof, and a pharmaceutical composition for the treatment and/or prevention of a cancer, comprising this antibody or fragment as an active ingredient.

Abstract: The invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

Abstract: It is intended to provide a CAPRIN-1-targeting antibody superior in antitumor activity to conventional antibodies, and use thereof as a therapeutic and/or preventive agent for a cancer. The present invention provides an antibody targeting a CAPRIN-1 polypeptide specifically expressed on the surface of cancer cells, and use of the antibody as a therapeutic and/or preventive agent for a cancer. The present invention provides an antibody which comprises a heavy chain variable region comprising complementarity-determining regions of SEQ ID NOs: 1, 2, and 3 and a light chain variable region comprising complementarity-determining regions of SEQ ID NOs: 4, 5, and 6 and has immunological reactivity with a CAPRIN-1 protein, or a fragment thereof, and a pharmaceutical composition for the treatment and/or prevention of a cancer, comprising this antibody or fragment as an active ingredient.

Abstract: Provided is an antibody effective for treatment and/or prevention of liver cancer. A pharmaceutical composition for treatment and/or prevention of liver cancer contains as an active ingredient an antibody or a fragment thereof having immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising at least seven consecutive amino acid residues of the amino acid sequence of the protein.

Abstract: This invention relates to a pharmaceutical composition for treatment and/or prevention of pancreatic cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 to 12 or more consecutive amino acid residues.

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.

Abstract: It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.

Abstract: An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.

Abstract: Provided is an antibody effective for treatment and/or prevention of liver cancer. A pharmaceutical composition for treatment and/or prevention of liver cancer contains as an active ingredient an antibody or a fragment thereof having immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising at least seven consecutive amino acid residues of the amino acid sequence of the protein.

Abstract: The present invention provides a method for producing a ceramic laminate capable of preventing coming-off of materials and warpage of the ceramic laminate by a heat treatment at a relatively-low temperature, and a ceramic laminate produced by the production method. Disclosed is a method for producing a ceramic laminate having a layer structure in which two or more layers are laminated, including: a step of producing a laminate including a first layer and a second layer, the first layer containing a solid electrolyte and the second layer containing at least composite particles obtained by covering an electrode active material with the solid electrolyte; and a step of performing a heat treatment on the laminate including the first and second layers at a temperature of 500° C. or more and less than 700° C.

Abstract: The invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.