Patents by Inventor Yoshitaka Nakazawa
Yoshitaka Nakazawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11529374Abstract: It is an object of the present invention to provide an extract from inflamed skins of rabbits inoculated with vaccinia virus wherein the quality is more stabilized, and a preparation containing the extract, etc. The use of the amount of N-acetylneuraminic acid contained in an extract from inflamed skins of rabbits inoculated with vaccinia virus and a preparation containing the extract as an index makes possible to warrant the quality of each manufacturing lot of the extract and the preparation in more stable manner. The extract from inflamed skins of rabbits inoculated with vaccinia virus and the preparation containing the extract which are manufactured as above, and in which the quality thereof becomes more stable, are warranted to maintain efficacy and safety in more strict manner, and thus extremely useful.Type: GrantFiled: December 6, 2018Date of Patent: December 20, 2022Assignee: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Yoshitaka Nakazawa, Yoji Shibayama, Ko Nakamura
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Publication number: 20190151370Abstract: It is an object of the present invention to provide an extract from inflamed skins of rabbits inoculated with vaccinia virus wherein the quality is more stabilized, and a preparation containing the extract, etc. The use of the amount of N-acetylneuraminic acid contained in an extract from inflamed skins of rabbits inoculated with vaccinia virus and a preparation containing the extract as an index makes possible to warrant the quality of each manufacturing lot of the extract and the preparation in more stable manner. The extract from inflamed skins of rabbits inoculated with vaccinia virus and the preparation containing the extract which are manufactured as above, and in which the quality thereof becomes more stable, are warranted to maintain efficacy and safety in more strict manner, and thus extremely useful.Type: ApplicationFiled: December 6, 2018Publication date: May 23, 2019Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Yoshitaka NAKAZAWA, Yoji SHIBAYAMA, Ko NAKAMURA
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Patent number: 9884077Abstract: An extract from inflamed skins of rabbits inoculated with vaccinia virus is provided where the quality of the extract is more stabilized. A preparation, etc. containing said extract as an active ingredient is also provided. When the amount of sulfated tyrosine contained in an extract from inflamed skins of rabbits inoculated with vaccinia virus and also contained in a preparation containing said extract as an active ingredient is used as an index, the quality of the extract and the preparation among the manufacturing lots can be warranted as a more stabilized one. In the extract from inflamed skins of rabbits inoculated with vaccinia virus and the preparation containing said extract where the quality thereof is more stabilized by such a method, the efficacy and the safety thereof are now guaranteed more strictly resulting in very high usefulness.Type: GrantFiled: April 30, 2014Date of Patent: February 6, 2018Assignee: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Yoshitaka Nakazawa, Yoji Shibayama, Ko Nakamura
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Patent number: 9540338Abstract: A cinnamic acid amide derivative having an excellent analgesic action is disclosed herein. The cinnamic acid amide derivative shows excellent analgesic actions to not only a nociceptive pain model animal, but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains. The cinnamic acid amide derivative may be a compound represented by formula (I).Type: GrantFiled: December 27, 2013Date of Patent: January 10, 2017Assignee: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Tomohiro Ookubo, Ko Nakamura, Yoshitaka Nakazawa, Hiroyoshi Nanba, Hiroyuki Yoshida
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Publication number: 20160089402Abstract: An object of the present invention is to provide an extract from inflamed skins of rabbits inoculated with vaccinia virus where the quality of the extract is more stabilized and also to provide a preparation, etc. containing said extract as an active ingredient. When the amount of sulfated tyrosine contained in an extract from inflamed skins of rabbits inoculated with vaccinia virus and also contained in a preparation containing said extract as an active ingredient is used as an index, the quality of the extract and the preparation among the manufacturing lots can be warranted as a more stabilized one. In the extract from inflamed skins of rabbits inoculated with vaccinia virus and the preparation containing said extract where the quality thereof is more stabilized by such a method, the efficacy and the safety thereof are now guaranteed more strictly resulting in very high usefulness.Type: ApplicationFiled: April 30, 2014Publication date: March 31, 2016Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Yoshitaka NAKAZAWA, Yoji SHIBAYAMA, Ko NAKAMURA
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Publication number: 20150322024Abstract: The present invention provides a cinnamic acid amide derivative having an excellent analgesic action. The cinnamic acid amide derivative of the present invention is a compound showing excellent analgesic actions to not only a nociceptive pain model animal but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains.Type: ApplicationFiled: December 27, 2013Publication date: November 12, 2015Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Tomohiro OOKUBO, Ko NAKAMURA, Yoshitaka NAKAZAWA, Hiroyoshi NANBA, Hiroyuki YOSHIDA
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Patent number: 9150510Abstract: The amino acid derivative of the present invention provides a novel compound that shows excellent analgesic action. The amino acid derivative of the present invention is a novel compound that shows excellent analgesic action to not only a model animal for nociceptive pains but also a model animal for neuropathic pains, so that the amino acid derivative is very useful as a drug for treating various pain diseases.Type: GrantFiled: September 17, 2009Date of Patent: October 6, 2015Assignee: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Tomohiro Ookubo, Ko Nakamura, Hiroyoshi Nanba, Hiroyuki Yoshida, Yoshitaka Nakazawa
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Publication number: 20150265655Abstract: It is an object of the present invention to provide an extract from inflamed skins of rabbits inoculated with vaccinia virus wherein the quality is more stabilized, and a preparation containing the extract, etc. The use of the amount of N-acetylneuraminic acid contained in an extract from inflamed skins of rabbits inoculated with vaccinia virus and a preparation containing the extract as an index makes possible to warrant the quality of each manufacturing lot of the extract and the preparation in more stable manner. The extract from inflamed skins of rabbits inoculated with vaccinia virus and the preparation containing the extract which are manufactured as above, and in which the quality thereof becomes more stable, are warranted to maintain efficacy and safety in more strict manner, and thus extremely useful.Type: ApplicationFiled: October 9, 2013Publication date: September 24, 2015Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Yoshitaka Nakazawa, Yoji Shibayama, Ko Nakamura
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Patent number: 8492350Abstract: A method for treating neuropathic pain by administering a pharmaceutical preparation containing N-acetylneuraminic acid or a pharmaceutically acceptable salt thereof to a person in need of treatment of neuropathic pain. Examples of neuropathic pain include trigeminal neuralgia, postherpetic neuralgia, strangulated neuropathy, complex regional pain syndrome (CRPS), diabetic neuropathy, neuropathy caused by trauma, phantom limb pain, central pain, and neuropathic pain caused by drug therapy or radiation therapy.Type: GrantFiled: February 6, 2008Date of Patent: July 23, 2013Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventor: Yoshitaka Nakazawa
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Patent number: 8324261Abstract: The present invention is to provide a novel compound which is useful as a pharmaceutical agent such as an analgesic. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present invention has a very high intermigration into the blood upon oral administration and is very useful as a pharmaceutical agent, especially an analgesic for the treatment of acute or chronic pain diseases and of neuropathic pain diseases.Type: GrantFiled: July 18, 2008Date of Patent: December 4, 2012Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Yoshitaka Nakazawa, Kenji Mitsuda, Tomohiro Ookubo, Teppei Seguchi, Hiroyoshi Nanba
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Patent number: 8236844Abstract: A novel histidine derivative represented by the following formula (I), and a pharmaceutically acceptable salt and hydrate thereof, useful as a pharmaceutical agent such as analgesics for the treatment of various kinds of acute or chronic pain diseases and of neuropathic pain diseases: wherein, R1 is hydrogen, alkyl having 1 to 6 carbon(s) or benzyl which may be substituted with alkyl having 1 to 4 carbon(s) or halogen; R2 is hydrogen or alkyl having 1 to 4 carbon(s); R3 and R4 are same or different and each is hydrogen, alkyl having 1 to 4 carbon(s) or phenyl which may be substituted with any one or two of alkyl having 1 to 6 carbon(s), alkoxy having 1 to 6 carbon(s), halogen, trifluoromethyl, nitro and cyano; and R5 is hydrogen or an alkyl group having 1 to 4 carbon(s).Type: GrantFiled: January 23, 2007Date of Patent: August 7, 2012Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Ko Nakamura, Yoshitaka Nakazawa, Minoru Kawamura, Kunihiko Higashiura, Tomoshi Miura
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Publication number: 20110172442Abstract: The amino acid derivative of the present invention provides a novel compound that shows excellent analgesic action. The amino acid derivative of the present invention is a novel compound that shows excellent analgesic action to not only a model animal for nociceptive pains but also a model animal for neuropathic pains, so that the amino acid derivative is very useful as a drug for treating various pain diseases.Type: ApplicationFiled: September 17, 2009Publication date: July 14, 2011Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Tomohiro Ookubo, Ko Nakamura, Hiroyoshi Nanba, Hiroyuki Yoshida, Yoshitaka Nakazawa
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Publication number: 20100152459Abstract: The present invention is to provide a novel compound which is useful as a pharmaceutical agent such as an analgesic. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present invention has a very high intermigration into the blood upon oral administration and is very useful as a pharmaceutical agent, especially an analgesic for the treatment of acute or chronic pain diseases and of neuropathic pain diseases.Type: ApplicationFiled: July 18, 2008Publication date: June 17, 2010Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Yoshitaka Nakazawa, Kenji Mitsuda, Tomohiro Ookubo, Teppei Seguchi, Hiroyoshi Nanba
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Publication number: 20100121040Abstract: Disclosed is an analgesic agent for a non-inflammatory pain disease, which comprises a sialic acid or a pharmaceutically acceptable salt thereof as an active ingredient. The sialic acid which is an active ingredient for the agent has an analgesic effect on a disease model animal of neurogenic pain which is a non-inflammatory pain. Therefore, the analgesic agent is useful as a pharmaceutical agent for the treatment of a non-inflammatory pain disease such as a neurogenic pain disease, e.g. trigeminal neuralgia, postherpetic neuralgia, entrapment neuropathy, complex regional pain syndrome, diabetic neuropathy, traumatic neuropathy, phantom limb pain, central pain after spinal cord injury or stroke, and neuropathy caused by pharmacotherapy or radiation therapy, or the like.Type: ApplicationFiled: February 6, 2008Publication date: May 13, 2010Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventor: Yoshitaka Nakazawa
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Publication number: 20090149658Abstract: The present invention is to provide a novel compound which is useful as an excellent analgesic agent. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present invention is very useful as a pharmaceutical agent such as analgesics for the treatment of various kinds of acute or chronic pain diseases and of neuropathic pain diseases.Type: ApplicationFiled: January 23, 2007Publication date: June 11, 2009Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Ko Nakamura, Yoshitaka Nakazawa, Minoru Kawamura, Kunihiko Higashiura, Tomoshi Miura