Patents by Inventor Yoshitaka Numajiri

Yoshitaka Numajiri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enantioselective synthesis of ?-quaternary Mannich adducts by palladium-catalyzed allylic alkylation
    Patent number: 11377396
    Abstract: This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: July 5, 2022
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Yoshitaka Numajiri, Beau P. Pritchett, Koji Chiyoda
  • Guanidine derivative and medical use thereof
    Patent number: 10662156
    Abstract: A compound has a guanidine skeleton that inhibits the protease activity of MALT1 and exerts a therapeutic or prophylactic effect on autoimmune disease such as psoriasis or allergic disease such as atopic dermatitis. The guanidine derivative is typified by the following formula or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: May 26, 2020
    Assignee: Toray Industries, Inc.
    Inventors: Yoshitaka Numajiri, Keiichi Okimura, Yuki Matsumura, Kennunettsu Asaba, Tomohide Masuda, Kazuyuki Tokumaru, Yasufumi Goto, Shigeo Fujii
  • ENANTIOSELECTIVE SYNTHESIS OF ALPHA-QUATERNARY MANNICH ADDUCTS BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION
    Publication number: 20200157020
    Abstract: This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
    Type: Application
    Filed: September 23, 2019
    Publication date: May 21, 2020
    Inventors: Brian M. Stoltz, Yoshitaka Numajiri, Beau P. Pritchett, Koji Chiyoda
  • Enantioselective synthesis of ?-quaternary mannich adducts by palladium-catalyzed allylic alkylation
    Patent number: 10421696
    Abstract: This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: September 24, 2019
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Yoshitaka Numajiri, Beau P. Pritchett, Koji Chiyoda
  • GUANIDINE DERIVATIVE AND MEDICAL USE THEREOF
    Publication number: 20190233376
    Abstract: A compound has a guanidine skeleton that inhibits the protease activity of MALT1 and exerts a therapeutic or prophylactic effect on autoimmune disease such as psoriasis or allergic disease such as atopic dermatitis. The guanidine derivative is typified by the following formula or a pharmacologically acceptable salt thereof.
    Type: Application
    Filed: July 28, 2017
    Publication date: August 1, 2019
    Inventors: Yoshitaka Numajiri, Keiichi Okimura, Yuki Matsumura, Kennunettsu Asaba, Tomohide Masuda, Kazuyuki Tokumaru, Yasufumi Goto, Shigeo Fujii
  • ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST
    Publication number: 20190055182
    Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.
    Type: Application
    Filed: October 22, 2018
    Publication date: February 21, 2019
    Inventors: Brian M. Stoltz, Alexander N. Marziale, Robert A. Craig, Douglas Duquette, Kelly E. Kim, Marc Liniger, Yoshitaka Numajiri
  • Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst
    Patent number: 10106479
    Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: October 23, 2018
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Alexander N. Marziale, Robert A. Craig, Douglas Duquette, Kelly E. Kim, Marc Liniger, Yoshitaka Numajiri
  • ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST
    Publication number: 20160280623
    Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.
    Type: Application
    Filed: March 25, 2016
    Publication date: September 29, 2016
    Inventors: Brian M. Stoltz, Alexander N. Marziale, Robert A. Craig, Douglas Duquette, Kelly E. Kim, Marc Liniger, Yoshitaka Numajiri
  • ENANTIOSELECTIVE SYNTHESIS OF alpha-QUATERNARY MANNICH ADDUCTS BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION
    Publication number: 20160176773
    Abstract: This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
    Type: Application
    Filed: December 17, 2015
    Publication date: June 23, 2016
    Inventors: Brian M. Stoltz, Yoshitaka Numajiri, Beau P. Pritchett, Koji Chiyoda
  • ENANTIOSELECTIVE SYNTHESIS OF DIALKYLATED N,O-HETEROCYCLES BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION
    Publication number: 20160096810
    Abstract: This invention provides enantioenriched N,O-heterocyclic compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
    Type: Application
    Filed: October 7, 2015
    Publication date: April 7, 2016
    Inventors: Brian M. Stoltz, Yoshitaka Numajiri, Douglas C. Behenna