Patents by Inventor Yoshiteru Eikyu
Yoshiteru Eikyu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7750155Abstract: This invention relates to novel N-hydroxyacrylamide compounds of formula (I) and pharmaceutically acceptable salts thereof. More particularly, it relates to novel N-hydroxyacrylamide compounds and pharmaceutically acceptable salts thereof which act as a HDAC inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of HDAC-related disease.Type: GrantFiled: February 6, 2007Date of Patent: July 6, 2010Assignee: Astellas Pharma Inc.Inventors: Fumiyuki Shirai, Hideo Tsutsumi, Hiromichi Itani, Yoshihiro Kozuki, Yoshiteru Eikyu, Taro Masunaga
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Publication number: 20100069388Abstract: A compound having the following formula (I): wherein —R1 is hydrogen, optionally substituted lower alkyl, cyclo(lower)alkyl, cyclo(higher)alkyl, optionally substituted aryl, optionally substituted heterocyclyl, or aryl-fused cyclo(lower)alkyl, R2 is hydrogen or halogen, Z is CH or N, X is formula (II) R3 is lower alkyl which may be substituted with —OH or optionally substituted aryl, or lower alkanoyl, R4 is hydrogen or lower alkyl, Y is optionally substituted lower alkylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.Type: ApplicationFiled: December 14, 2007Publication date: March 18, 2010Applicant: ASTELLAS PHARMA INC.Inventors: Yoshikazu Inoue, Yoshiteru Eikyu, Fumiyuki Shirai
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Patent number: 7557127Abstract: Compounds having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is pyrrolidinylene or piperidinylene, Y is pyridylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, and salts thereof are useful as a histone deacetylase inhibitors.Type: GrantFiled: November 4, 2008Date of Patent: July 7, 2009Assignee: Astellas Pharma Inc.Inventors: Naoki Ishibashi, Yuki Sawada, Yasuharu Urano, Shigeki Satoh, Yoshikazu Inoue, Yoshiteru Eikyu, Koichiro Mukoyoshi, Kazunori Kamijo, Fumiyuki Shirai, Hisashi Takasugi
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Publication number: 20090054465Abstract: This invention relates to novel N-hydroxyacrylamide compounds of formula (I) and pharmaceutically acceptable salts thereof. More particularly, it relates to novel N-hydroxyacrylamide compounds and pharmaceutically acceptable salts thereof which act as a HDAC inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of HDAC-related disease.Type: ApplicationFiled: February 6, 2007Publication date: February 26, 2009Applicant: Astella Pharma Inc.Inventors: Fumiyuki Shirai, Hideo Tsutsumi, Hiromichi Itani, Yoshihiro Kozuki, Yoshiteru Eikyu, Taro Masunaga
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Publication number: 20090054464Abstract: Compounds having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is pyrrolidinylene or piperidinylene, Y is pyridylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, and salts thereof are useful as a histone deacetylase inhibitors.Type: ApplicationFiled: November 4, 2008Publication date: February 26, 2009Applicant: Astellas Pharma Inc.Inventors: Naoki ISHIBASHI, Yuki SAWADA, Yasuharu URANO, Shigeki SATOH, Yoshikazu INOUE, Yoshiteru EIKYU, Koichiro MUKOYOSHI, Kazunori KAMIJO, Fumiyuki SHIRAI, Hisashi TAKASUGI
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Patent number: 7465731Abstract: A compound having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is arylene, heterorarylene, cycloalkylene, heterocycloalkylene or aryl-fused cycloalkene, Y is arylene, heteroarylene, which may be substituted with one or more suitable substituent(s), Z lower alenylene, which may be substituted with lower alkyl or halogen, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.Type: GrantFiled: August 9, 2005Date of Patent: December 16, 2008Assignee: Astellas Pharma Inc.Inventors: Naoki Ishibashi, Yuki Sawada, Yasuharu Urano, Shigeki Satoh, Yoshikazu Inoue, Yoshiteru Eikyu, Koichiro Mukoyoshi, Kazunori Kamijo, Fumiyuki Shirai, Hisashi Takasugi
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Publication number: 20070123532Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: ApplicationFiled: November 21, 2006Publication date: May 31, 2007Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Kazuhiko Take, Nobukiyo Konishi, Shinji Shigenaga, Natsuko Kayakiri, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Masataka Morita
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Patent number: 7166598Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: GrantFiled: October 20, 2004Date of Patent: January 23, 2007Assignee: Astellas Pharma Inc.Inventors: Kazuhiko Take, Nobukiyo Konishi, Shinji Shigenaga, Natsuko Kayakiri, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Masataka Morita
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Publication number: 20060052599Abstract: A compound having the following formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower) alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is arylene, heteroarylene, cycloalkylene, heterocycloalkylene or aryl-fused cycloalkylene, Y is arylene or heteroarylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.Type: ApplicationFiled: August 9, 2005Publication date: March 9, 2006Applicant: Astellas Pharma Inc.Inventors: Naoki Ishibashi, Yuki Sawada, Yasuharu Urano, Shigeki Satoh, Yoshikazu Inoue, Yoshiteru Eikyu, Koichiro Mukoyoshi, Kazunori Kamijo, Fumiyuki Shirai, Hisashi Takasugi
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Publication number: 20060014948Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: ApplicationFiled: October 20, 2004Publication date: January 19, 2006Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Kazuhiko Take, Nobukiyo Konishi, Shinji Shigenaga, Natsuko Kayakiri, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Masataka Morita
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Publication number: 20050171350Abstract: A compound of the formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.Type: ApplicationFiled: December 16, 2002Publication date: August 4, 2005Applicant: Fujisawa Pharamaceutical Co., Ltd.Inventors: Kazuhiko Take, Chiyoshi Kasahara, Shinji Shigenaga, Yoshiteru Eikyu, Takashi Tojo
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Patent number: 6924278Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: GrantFiled: November 24, 2003Date of Patent: August 2, 2005Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroshi Miyake, Kazuhiko Take, Shinji Shigenaga, Hidenori Azami, Hiroshi Sasaki, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Takashi Manabe, Nobukiyo Konishi, Tadashi Terasaka
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Publication number: 20050027121Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: ApplicationFiled: November 24, 2003Publication date: February 3, 2005Applicant: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroshi Miyake, Kazuhiko Take, Shinji Shigenaga, Hidenori Azami, Hiroshi Sasaki, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Takashi Manabe, Nobukiyo Konishi, Tadashi Terasaka
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Publication number: 20040220403Abstract: A compound of the formula (I): wherein in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.Type: ApplicationFiled: June 30, 2003Publication date: November 4, 2004Inventors: Kazuhiko Take, Chiyoshi Kasahara, Shinji Shigenaga, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Masataka Morita
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Patent number: 6787543Abstract: A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.Type: GrantFiled: December 20, 2002Date of Patent: September 7, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kazuhiko Take, Chiyoshi Kasahara, Shinji Shigenaga, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Masataka Morita
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Publication number: 20030176430Abstract: A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.Type: ApplicationFiled: December 20, 2002Publication date: September 18, 2003Inventors: Kazuhiko Take, Chiyoshi Kasahara, Shinji Shigenaga, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Masataka Morita
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Publication number: 20030114668Abstract: This invention relates to piperazine derivatives of formula (I), wherein Y is bond or lower alkylene, R1 is aryl which may have substituent(s), R2 is aryl or indolyl, each of which may have substituent(s), R3 is hydrogen or lower alkyl, and R4 is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human beings or animals.Type: ApplicationFiled: January 7, 2000Publication date: June 19, 2003Inventors: HIROSHI MIYAKE, KAZUHIKO TAKE, SHINJI SHIGENAGA, HIDENORI AZAMI, HIROSHI SASAKI, YOSHITERU EIKYU, KAZUO NAKAI, JUNYA ISHIDA, TAKASHI MANABE, NOBUKIYO KONISHI, TADASHI TERASAKA
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Patent number: 6159961Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is hydrogen or hydroxy protective group,R.sup.3 is carboxy or protected carboxy,R.sup.4 is hydrogen, lower alkenyl, acyloxy(lower)alkenyl, optionally substituted heterocyclic(lower)alkenyl, optionally substituted heterocyclic(lower)alkenylthio, optionally substituted heterocyclic(lower)alkylthio, or optionally substituted heterocyclic-thio(lower)alkylthio andR5 is halogen or lower alkyland pharmaceutically acceptable salts thereof, which is useful as a medicament for prophylactic and therapeutic treatment of infectious diseases.Type: GrantFiled: July 19, 1999Date of Patent: December 12, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kohji Kawabata, Hirofumi Yamamoto, Yoshiteru Eikyu, Shinya Okuda, Hisashi Takasugi
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Patent number: 5958914Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is amino, R.sup.2 is hydrogen,R.sup.3 is carboxy,R.sup.4 is heterocyclic(lower)alkylthio wherein said heterocyclic group is pyrazolyl and said lower alkyl group is methyl, andR.sup.5 is halogen; and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 26, 1998Date of Patent: September 28, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kohji Kawabata, Hirofumi Yamamoto, Yoshiteru Eikyu, Shinya Okuda, Hisashi Takasugi