Abstract: Disclosed is an image synthesizer including an image frames memory which memorizes a plurality of image frames which are produced by continuously taking pictures of a subject, an image synthesizer which synthesizes a plurality of image frames to a summation image, an image brightness adjuster which adjusts brightness of the summation image by synthesizing the image frames with the image synthesizer, and a display which displays the summation image which is being synthesized by the image synthesizing means in the image brightness adjusting processing.

Abstract: To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.

Abstract: [Problems] To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.

Abstract: To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.

Abstract: To achieve more appropriate interpolation of a missing pixel, an image is input to a processing section for interpolation. The interpolation is applied utilizing image data of pixels located around the pixel to be interpolated. Specifically, correlations between the image data of the pixels to be interpolated, and pixel data in a horizontal direction, vertical direction, and diagonal direction, are compared to one another; pixel data having stronger correlation is used for the interpolation. Correlation between the image data of the pixels to be interpolated and which direction is strong is determined, so that different weighting for interpolation is used accordingly.

Abstract: Disclosed is an image synthesizer including an image frames memory which memorizes a plurality of image frames which are produced by continuously taking pictures of a subject, an image synthesizer which synthesizes a plurality of image frames to a summation image, an image brightness adjuster which adjusts brightness of the summation image by synthesizing the image frames with the image synthesizer, and a display which displays the summation image which is being synthesized by the image synthesizing means in the image brightness adjusting processing.

Abstract: [Problems] To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.

Abstract: The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-? mediated diseases.

Abstract: In a computer generation of a dither mask for conversion of a continuous-tone image into a halftone image, a pixel array having a size in accordance with the dither mask is partitioned into blocks. Initial pixel values are determined such that the occurrences of pixel values will be substantially uniform in the blocks. A pair of exchange target pixels are selected at random from the pixels in one of the blocks and function values of a predetermined evaluation function that indicates a characteristic of the pixel value configuration of the pixels in this block are computed for the two cases where pixel values are exchanged among the exchange target pixels and where not exchanged. These function values are compared to judge whether exchange should be performed.

Abstract: The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-? mediated diseases

Abstract: To achieve more appropriate interpolation of a missing pixel, an image is input to a processing section for interpolation. The interpolation is applied utilizing image data of pixels located around the pixel to be interpolated. Specifically, correlations between the image data of the pixels to be interpolated, and pixel data in a horizontal direction, vertical direction, and diagonal direction, are compared to one another; pixel data having stronger correlation is used for the interpolation. Correlation between the image data of the pixels to be interpolated and which direction is strong is determined, so that different weighting for interpolation is used accordingly.

Abstract: The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-? mediated diseases

Abstract: The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-? mediated diseases.

Abstract: Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy inhibitory action.

Abstract: The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-? mediated diseases.

Abstract: A sulfonamide compound of the formula (I): R1—SO2NHCO—A—X—R2??(I) wherein R1 is alky, alkenyl, alkynyl and the like; A is an optionally substitutedheteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyland 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.

Abstract: The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

Abstract: The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-? mediated diseases.

Abstract: A compound of the formula: in which R1 is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted bicyclic heterocyclic group, optionally substituted lower alkenyl or optionally substituted lower alkynyl, and R2 is carboxy or protected carboxy, or a salt thereof, useful for treating and/or preventing MMP- or TNF-&agr; mediated diseases.

Abstract: A sulfonamide compound of the formula (I):