Patents by Inventor Yoshitsugu Akiyama

Yoshitsugu Akiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing folic acid derivatives
    Patent number: 7585973
    Abstract: This invention provides a process for efficient production of folic acid derivatives suitable for forming conjugates of anticancer drug with folic acid. It discloses a process comprising a step of reacting 2-amino-protected pteroylimidazole with ?-lower alkyl glutamate; and a step of reacting the resulting product with an amino compound having a reactive group which is readily reactable with a functional group of the drug.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: September 8, 2009
    Assignee: Japan Science and Technology Agency
    Inventors: Kazunori Kataoka, Yoshitsugu Akiyama
  • Process for producing folic acid derivatives
    Publication number: 20070142387
    Abstract: This invention provides a process for efficient production of folic acid derivatives suitable for forming conjugates of anticancer drug with folic acid. It discloses a process comprising a step of reacting 2-amino-protected pteroylimidazole with ?-lower alkyl glutamate; and a step of reacting the resulting product with an amino compound having a reactive group which is readily reactable with a functional group of the drug.
    Type: Application
    Filed: March 25, 2005
    Publication date: June 21, 2007
    Inventors: Kazunori Kataoka, Yoshitsugu Akiyama
  • Block copolymers having polymer segment derived from oxazoline
    Patent number: 6974856
    Abstract: Disclosed are block copolymers represented by the following general formula (I) wherein AI represents a hydroxyl group or an organic residue derived from an anionic polymerization initiator, R represents a hydrogen atom or an acyl group, NP represents a residue derived from a nucleophilic reagent, m is an integer of 2 to 20,000, and n is an integer of 1 to 20,000.
    Type: Grant
    Filed: June 27, 2000
    Date of Patent: December 13, 2005
    Assignee: Nanocarrier Co., Ltd.
    Inventors: Kazunori Kataoka, Yukio Nagasaki, Yoshitsugu Akiyama
  • Biochip sensor surface carrying polyethylene glycolated nanoparticles
    Publication number: 20050106570
    Abstract: The invention provides high sensitivity bioassay sensor systems in which non-specific adsorption of impurities such as, for example, proteins, in biological samples is inhibited. Polyethylene glycolated particles enclosing metal or semi-conductor which is in common with the sensor material are used for amplification.
    Type: Application
    Filed: March 24, 2003
    Publication date: May 19, 2005
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Kazunori Kataoka, Yukio Nagasaki, Hidenori Otsuka, Katsumi Uchida, Takehiko Ishii, Yuko Suzuki, Yoshitsugu Akiyama, Seiji Takae