Patents by Inventor Yoshiya Sugai
Yoshiya Sugai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10143667Abstract: Provided are an agent for imparting ceramide-like function, an agent for reinforcing skin barrier function, a moisturizing agent and a skin drug for external use. The agent for imparting ceramide-like function comprises as an effective ingredient a derivative of succinic acid diamide represented by the following formula (1): [wherein R1 and R2 each independently represents a hydroxyalkyl group of from 1 to 6 carbon atoms, R3 represents a group: —CH2CH2CH2CH2—R4 or a group: —CH2CH?CHCH2—R4 (wherein R4 represents an alkyl group of from 8 to 26 carbon atoms)].Type: GrantFiled: March 11, 2014Date of Patent: December 4, 2018Assignee: KAO CORPORATIONInventors: Yoshiya Sugai, Taisuke Aosaki
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Patent number: 10064800Abstract: A transglutaminase activator containing at least one kind selected from the group consisting of an extract from Justicia procumbens, an extract from Peristrophe japonica, and a compound represented by Formula (1), as an active ingredient: wherein R1 and R2 represent a hydrogen atom, a hydroxyl group, or an alkoxy group having 1 to 4 carbon atoms; R3 represents a hydrogen atom, or a group for forming a methylenedioxy group by bonding with R2; R4 and R5 represent a hydrogen atom, or a group for forming a methylenedioxy group by bonding with each other; R6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms, an acyloxy group having 1 to 4 carbon atoms, or a specific sugar residue.Type: GrantFiled: August 29, 2013Date of Patent: September 4, 2018Assignee: Kao CorporationInventors: Junko Ishikawa, Shino Mitsunaga, Shi Chen, Akiko Kawasaki, Yoshiya Sugai, Yoshie Shimotoyodome, Naoki Oya
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Patent number: 9682029Abstract: A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovata, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).Type: GrantFiled: August 5, 2016Date of Patent: June 20, 2017Assignee: Kao CorporationInventors: Yoshie Shimotoyodome, Shotaro Ito, Yoshiya Sugai, Hiroshi Hashimoto, Junko Ishikawa
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Publication number: 20160338933Abstract: A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovata, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).Type: ApplicationFiled: August 5, 2016Publication date: November 24, 2016Applicant: Kao CorporationInventors: Yoshie SHIMOTOYODOME, Shotaro Ito, Yoshiya Sugai, Hiroshi Hashimoto, Junko Ishikawa
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Patent number: 9445987Abstract: A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovate, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).Type: GrantFiled: September 27, 2010Date of Patent: September 20, 2016Assignee: Kao CorporationInventors: Yoshie Shimotoyodome, Shotaro Ito, Yoshiya Sugai, Hiroshi Hashimoto, Junko Ishikawa
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Publication number: 20160038443Abstract: Provided are an agent for imparting ceramide-like function, an agent for reinforcing skin barrier function, a moisturizing agent and a skin drug for external use. The agent for imparting ceramide-like function comprises as an effective ingredient a derivative of succinic acid diamide represented by the following formula (1): [wherein R1 and R2 each independently represents a hydroxyalkyl group of from 1 to 6 carbon atoms, R3 represents a group: —CH2CH2CH2CH2—R4 or a group: —CH2CH?CHCH2—R4 (wherein R4 represents an alkyl group of from 8 to 26 carbon atoms)].Type: ApplicationFiled: March 11, 2014Publication date: February 11, 2016Applicant: KAO CORPORATIONInventors: Yoshiya SUGAI, Taisuke AOSAKI
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Publication number: 20150238404Abstract: A transglutaminase activator containing at least one kind selected from the group consisting of an extract from Justicia procumbens, an extract from Peristrophe japonica, and a compound represented by Formula (1), as an active ingredient: wherein R1 and R2 represent a hydrogen atom, a hydroxyl group, or an alkoxy group having 1 to 4 carbon atoms; R3 represents a hydrogen atom, or a group for forming a methylenedioxy group by bonding with R2; R4 and R5 represent a hydrogen atom, or a group for forming a methylenedioxy group by bonding with each other; R6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms, an acyloxy group having 1 to 4 carbon atoms, or a specific sugar residue.Type: ApplicationFiled: August 29, 2013Publication date: August 27, 2015Applicant: Kao CorporationInventors: Junko Ishikawa, Shino Mitsunaga, Shi Chen, Akiko Kawasaki, Yoshiya Sugai, Yoshie Shimotoyodome, Naoki Oya
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Publication number: 20130244984Abstract: Provided are a drug, a cosmetic, etc. for promoting production of ceramide. Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.Type: ApplicationFiled: April 25, 2013Publication date: September 19, 2013Applicant: Kao CorporationInventors: Yoshiya SUGAI, Hiroshi HASHIMOTO, Shinya AMANO, Shotaro ITO, Yoshie SHIMOTOYODOME, Yoriko NAKAGIRI
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Patent number: 8440645Abstract: Provided are a drug, a cosmetic, etc. for promoting production of ceramide. Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.Type: GrantFiled: July 30, 2009Date of Patent: May 14, 2013Assignee: Kao CorporationInventors: Yoshiya Sugai, Hiroshi Hashimoto, Shinya Amano, Shotaro Ito, Yoshie Shimotoyodome, Yoriko Nakagiri
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Publication number: 20120196841Abstract: A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovate, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).Type: ApplicationFiled: September 27, 2010Publication date: August 2, 2012Applicant: Kao CorporationInventors: Yoshie Shimotoyodome, Shotaro Ito, Yoshiya Sugai, Hiroshi Hashimoto, Junko Ishikawa
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Publication number: 20110105439Abstract: Provided are a drug, a cosmetic, etc. for promoting production of ceramide. Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.Type: ApplicationFiled: July 30, 2009Publication date: May 5, 2011Applicant: Kao CorporationInventors: Yoshiya Sugai, Hiroshi Hashimoto, Shinya Amano, Shotaro Ito, Yoshie Shimotoyodome, Yoriko Nakagiri
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Patent number: 7550135Abstract: The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.Type: GrantFiled: October 19, 2004Date of Patent: June 23, 2009Assignee: Kao CorporationInventors: Masahide Hoshino, Hiroaki Saito, Yoshiya Sugai, Mituru Sugiyama, Yoshinori Nishizawa, Yasushi Katayama
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Patent number: 7528171Abstract: The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.Type: GrantFiled: December 9, 2003Date of Patent: May 5, 2009Assignee: Kao CorporationInventors: Masahide Hoshino, Hiroaki Saito, Yoshiya Sugai, Mituru Sugiyama, Yoshinori Nishizawa, Yasushi Katayama
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Patent number: 7351716Abstract: The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R1 represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, R2 represents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and R3 represents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.Type: GrantFiled: December 10, 2003Date of Patent: April 1, 2008Assignee: Kao CorporationInventors: Masahide Hoshino, Yoshiya Sugai, Akiyo Kameyama, Hiroaki Saito, Yoshinori Nishizawa, Yutaka Takagi
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Patent number: 7087646Abstract: The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.Type: GrantFiled: February 26, 2002Date of Patent: August 8, 2006Assignee: Kao CorporationInventors: Masahide Hoshino, Hiroaki Saito, Yoshiya Sugai, Mituru Sugiyama, Yoshinori Nishizawa, Yasushi Katayama
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Publication number: 20050112082Abstract: The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.Type: ApplicationFiled: October 19, 2004Publication date: May 26, 2005Applicant: Kao CorporationInventors: Masahide Hoshino, Hiroaki Saito, Yoshiya Sugai, Mituru Sugiyama, Yoshinori Nishizawa, Yasushi Katayama
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Publication number: 20040122103Abstract: The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): 1Type: ApplicationFiled: December 9, 2003Publication date: June 24, 2004Applicant: Kao CorporationInventors: Masahide Hoshino, Hiroaki Saito, Yoshiya Sugai, Mituru Sugiyama, Yoshinori Nishizawa, Yasushi Katayama
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Publication number: 20040115162Abstract: The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): 1Type: ApplicationFiled: December 10, 2003Publication date: June 17, 2004Applicant: KAO CORPORATIONInventors: Masahide Hoshino, Yoshiya Sugai, Akiyo Kameyama, Hiroaki Saito, Yoshinori Nishizawa, Yutaka Takagi
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Patent number: 6685953Abstract: The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R1 represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, R2 represents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and R3 represents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.Type: GrantFiled: October 4, 2001Date of Patent: February 3, 2004Assignee: Kao CorporationInventors: Masahide Hoshino, Yoshiya Sugai, Akiyo Kameyama, Hiroaki Saito, Yoshinori Nishizawa, Yutaka Takagi
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Publication number: 20030026818Abstract: The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): 1Type: ApplicationFiled: February 26, 2002Publication date: February 6, 2003Applicant: Kao CorporationInventors: Masahide Hoshino, Hiroaki Saito, Yoshiya Sugai, Mituru Sugiyama, Yoshinori Nishizawa, Yasushi Katayama