Patents by Inventor Yoshiyuki Morishima
Yoshiyuki Morishima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10266871Abstract: It is an object of the present invention to provide a measurement method capable of easily evaluating combined effects in a single assay system, when antithrombotic agents having different mechanisms of action are used in combination. A method for measuring thrombin generation comprising: (1) a step of adding an anticoagulant, a P2Y12 receptor inhibitor, adenosine diphosphate and tissue factor to platelet rich plasma; (2) a step of adding a fluorogenic thrombin substrate and a calcium-containing solution thereto; and (3) a step of measuring fluorescence intensity.Type: GrantFiled: December 17, 2013Date of Patent: April 23, 2019Assignee: Daiichi Sankyo Company, LimitedInventors: Yoshiyuki Morishima, Yuko Honda
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Patent number: 9988583Abstract: A method for producing a highly aromatic base oil of the present invention includes a step of hydrorefining a clarified oil to obtain a highly aromatic base oil having an aromatic content of 50% by mass or more determined by a column chromatography analysis method. The step of hydrorefining a clarified oil is preferably performed under conditions of a hydrogen pressure of 5.0 to 20.0 MPa, a temperature of 280 to 400° C., a hydrogen oil ratio of 300 to 750 NL/L, and a space velocity of 0.3 to 2.0 h?1. According to the present invention, a highly aromatic base oil used for rubber processing, asphalt reclamation and the like, and a novel method for producing a highly aromatic base oil can be provided.Type: GrantFiled: September 9, 2016Date of Patent: June 5, 2018Assignee: JX NIPPON OIL & ENERGY CORPORATIONInventors: Yoshiyuki Morishima, Takashi Ito
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Publication number: 20170368037Abstract: It is intended to provide a novel pharmaceutical composition that can promote fibrinolysis. The present invention provides a pharmaceutical composition for the promotion of fibrinolysis, comprising edoxaban or a pharmaceutically acceptable salt thereof, or a hydrate of the compound or the salt. The present invention further provides a pharmaceutical composition for the promotion of fibrinolysis, comprising edoxaban or a pharmaceutically acceptable salt thereof, or a hydrate of the compound or the salt and further comprising a TAFIa inhibitor.Type: ApplicationFiled: December 25, 2015Publication date: December 28, 2017Applicant: Daiichi Sankyo Company, LimitedInventors: Taketoshi Furugori, Yoshiyuki Morishima
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Publication number: 20170296521Abstract: It is intended to provide a novel pharmaceutical composition that can suppress thromboembolism after stent placement. The present invention provides a pharmaceutical composition for the suppression of thromboembolism after stent placement, comprising edoxaban or a pharmaceutically acceptable salt thereof, or a hydrate of the compound or the salt.Type: ApplicationFiled: September 1, 2015Publication date: October 19, 2017Applicant: Daiichi Sankyo Company, LimitedInventors: Yoshiyuki Morishima, Yuko Honda, Chikako Kamisato
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Publication number: 20160376510Abstract: A method for producing a highly aromatic base oil of the present invention includes a step of hydrorefining a clarified oil to obtain a highly aromatic base oil having an aromatic content of 50% by mass or more determined by a column chromatography analysis method. The step of hydrorefining a clarified oil is preferably performed under conditions of a hydrogen pressure of 5.0 to 20.0 MPa, a temperature of 280 to 400° C., a hydrogen oil ratio of 300 to 750 NL/L, and a space velocity of 0.3 to 2.0 h?1. According to the present invention, a highly aromatic base oil used for rubber processing, asphalt reclamation and the like, and a novel method for producing a highly aromatic base oil can be provided.Type: ApplicationFiled: September 9, 2016Publication date: December 29, 2016Applicant: JX NIPPON OIL & ENERGY CORPORATIONInventors: Yoshiyuki MORISHIMA, Takashi ITO
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Patent number: 9476006Abstract: A method for producing a highly aromatic base oil of the present invention includes a step of hydrorefining a clarified oil to obtain a highly aromatic base oil having an aromatic content of 50% by mass or more determined by a column chromatography analysis method. The step of hydrorefining a clarified oil is preferably performed under conditions of a hydrogen pressure of 5.0 to 20.0 MPa, a temperature of 280 to 400° C., a hydrogen oil ratio of 300 to 750 NL/L, and a space velocity of 0.3 to 2.0 h?1. According to the present invention, a highly aromatic base oil used for rubber processing, asphalt reclamation and the like, and a novel method for producing a highly aromatic base oil can be provided.Type: GrantFiled: January 7, 2013Date of Patent: October 25, 2016Assignee: JX NIPPON OIL & ENERGY CORPORATIONInventors: Yoshiyuki Morishima, Takashi Ito
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Publication number: 20150322480Abstract: It is an object of the present invention to provide a measurement method capable of easily evaluating combined effects in a single assay system, when antithrombotic agents having different mechanisms of action are used in combination. A method for measuring thrombin generation comprising: (1) a step of adding an anticoagulant, a P2Y12 receptor inhibitor, adenosine diphosphate and tissue factor to platelet rich plasma; (2) a step of adding a fluorogenic thrombin substrate and a calcium-containing solution thereto; and (3) a step of measuring fluorescence intensity.Type: ApplicationFiled: December 17, 2013Publication date: November 12, 2015Inventors: Yoshiyuki MORISHIMA, Yuko HONDA
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Publication number: 20150057205Abstract: A method for producing a highly aromatic base oil of the present invention includes a step of hydrorefining a clarified oil to obtain a highly aromatic base oil having an aromatic content of 50% by mass or more determined by a column chromatography analysis method. The step of hydrorefining a clarified oil is preferably performed under conditions of a hydrogen pressure of 5.0 to 20.0 MPa, a temperature of 280 to 400° C., a hydrogen oil ratio of 300 to 750 NL/L, and a space velocity of 0.3 to 2.0 h?1. According to the present invention, a highly aromatic base oil used for rubber processing, asphalt reclamation and the like, and a novel method for producing a highly aromatic base oil can be provided.Type: ApplicationFiled: January 7, 2013Publication date: February 26, 2015Inventors: Yoshiyuki Morishima, Takashi Ito
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Publication number: 20090318316Abstract: This invention relates to a lubricating oil composition being excellent in oxidation stability and low-temperature flowability, and more particularly to a lubricating oil composition characterized by using as a base oil a diester obtained from a straight-chain dihydric alcohol having a carbon number of 6 to 12 and having a hydroxyl group at both terminal carbon atoms respectively and a branched-chain saturated monovalent fatty acid having a carbon number of 6 to 12.Type: ApplicationFiled: August 23, 2007Publication date: December 24, 2009Applicant: JAPAN ENERGY CORPORATIONInventor: Yoshiyuki Morishima
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Publication number: 20090318317Abstract: Disclosed is a lubricating oil for a fluid bearing, which has a low viscosity, a reduced amount of evaporation, and superior low-temperature flowability. The lubricating oil includes, as a base oil, a high-purity diester synthesized from a carboxylic acid material containing 90 mass % or more of azelaic acid and an alcohol material containing 90 mass % or more of 2-ethyl-1-hexanol. The carboxylic acid material contains glutaric acid, adipic acid, pimelic acid, suberic acid, sebacic acid and 1,9-nanomethylenedicarboxylic acid in a total amount of 5 mass % or less.Type: ApplicationFiled: August 31, 2007Publication date: December 24, 2009Applicants: JAPAN ENERGY CORPORATION, NIDEC CORPORATIONInventor: Yoshiyuki MORISHIMA
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Patent number: 7601253Abstract: A process oil comprising a 95/5 to 5/95 by weight mixture of: an extract having a DMSO extractable content less than 3 wt % obtained by solvent-extracting an oil obtained by deasphalting a vacuum distillation bottom; and either a mineral oil base having a DMSO extractable content less than 3 wt % which is a raffinate obtained by the solvent refining of a vacuum distillate or a mineral oil base having a DMSO extractable content less than 3 wt % obtained by subjecting a raffinate obtained by the solvent refining of a vacuum distillate to hydrorefining and/or dewaxing. The process oil has a kinematic viscosity at 100° C. of less than 32 mm2/s, % CA of 15 to 30, aniline point of 100° C. or lower, weight change through evaporation of 0.5% or less, and mutagenicity index of less than 1.Type: GrantFiled: September 30, 2002Date of Patent: October 13, 2009Assignee: Japan Energy CorporationInventors: Takashi Kaimai, Yoshiyuki Morishima, Kenji Fujino
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Publication number: 20060254955Abstract: A process oil comprising a 95/5 to 5/95 by weight mixture of: an extract having a DMSO extractable content less than 3 wt % obtained by solvent-extracting an oil obtained by deasphalting a vacuum distillation bottom; and either a mineral oil base having a DMSO extractable content less than 3 wt % which is a raffinate obtained by the solvent refining of a vacuum distillate or a mineral oil base having a DMSO extractable content less than 3 wt % obtained by subjecting a raffinate obtained by the solvent refining of a vacuum distillate to hydrorefining and/or dewaxing. The process oil has a kinematic viscosity at lOOoC of less than 32 mm2/s, % CA of 15 to 30, aniline point of lOOoC or lower, weight change through evaporation of 0.5% or less, and mutagenicity index of less than 1.Type: ApplicationFiled: September 30, 2002Publication date: November 16, 2006Inventors: Takashi Kaimai, Yoshiyuki Morishima, Kenji Fujino
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Patent number: 6878263Abstract: Disclosed is a rubber process oil in which the content of polycyclic aromatics (PCAs) as determined by the IP 346 method is less than 3% by mass and which is rich in aromatic hydrocarbons, and a method for producing the same. The aniline point of the rubber process oil is 80° C. or less, and the % CA value as determined by ring analysis according to the Kurtz method is from 20 to 50%. The rubber process oil is produced by using extraction of lube oil fraction with a solvent having a selective affinity for aromatics. The extraction conditions are determined so that the extraction yield is regulated to a predetermined requirement defined by the PCAs content of the lube oil fraction. Alternatively, the extract is cooled to further separate into the extract and the raffinate, and the second raffinate is used for the rubber process oil.Type: GrantFiled: April 27, 2001Date of Patent: April 12, 2005Assignee: Japan Energy CorporationInventors: Takashi Kaimai, Kazumitsu Fujihara, Yoshiyuki Morishima
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Patent number: 6365037Abstract: A process for producing a low pour-point oil which permits the production of a lower pour point oil without severer hydrodewaxing conditions is disclosed, which comprises hydrodewaxing a mineral oil fraction, which has been separated from a crude oil by distillation and has a boiling point ranging from 250 to 600° C., at a temperature range of from 250° C. to 500° C. in the presence of a zeolite catalyst; and separating a lighter fraction by distillation.Type: GrantFiled: December 15, 1998Date of Patent: April 2, 2002Assignee: Japan Energy CorporationInventors: Kazumitu Fujihara, Yoshiyuki Morishima
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Publication number: 20010045377Abstract: A novel process for the production of an extract useful as a process oil and a raffinate useful as a high-viscosity base oil by solvent refining is provided, characterized in that reduced pressure distillation is effected under the condition that the end point of distillate is 580° C. or higher as calculated in terms of atmospheric pressure or the initial boiling point of the residue is 450° C. or higher as calculated in terms of atmospheric pressure, the resulting residual oil is deasphalted under the condition that the carbon residue content in the deasphalted oil reached 1.6% or less, and the resulting deasphalted oil is subjected to solvent refining under the condition that the yield of extract is from 35% to 60%. It is a novel and economically excellent process for the preparation of a rubber process oil having a high safety, a high penetrating power with respect to rubber polymer and the content of PCA extract of less than 3%.Type: ApplicationFiled: April 19, 2001Publication date: November 29, 2001Inventors: Yoshiyuki Morishima, Kenji Fujino
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Publication number: 20010023307Abstract: Disclosed is a rubber process oil in which the content of polycyclic aromatics (PCAs) as determined by the IP 346 method is less than 3% by mass and which is rich in aromatic hydrocarbons, and a method for producing the same. The aniline point of the rubber process oil is 80° C. or less, and the %CA value as determined by ring analysis according to the Kurtz method is from 20 to 50%. The rubber process oil is produced by using extraction of lube oil fraction with a solvent having a selective affinity for aromatics. The extraction conditions are determined so that the extraction yield is regulated to a predetermined requirement defined by the PCAs content of the lube oil fraction. Alternatively, the extract is cooled to further separate into the extract and the raffinate, and the second raffinate is used for the rubber process oil.Type: ApplicationFiled: April 27, 2001Publication date: September 20, 2001Applicant: Japan Energy CorporationInventors: Takashi Kaimai, Kazumitsu Fujihara, Yoshiyuki Morishima
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Patent number: 6248929Abstract: Disclosed is a rubber process oil in which the content of polycyclic aromatics (PCAs) as determined by the IP 346 method is less than 3% by mass and which is rich In aromatic hydrocarbons, and a method for producing the same. The aniline point of the rubber process oil is 80° C. or less, and the % CA value as determined by ring analysis according to the Kurtz method is from 20 to 50%. The rubber process oil is produced by using extraction of lube oil fraction with a solvent having a selective affinity for aromatics. The extraction conditions are determined so that the extraction yield is regulated to a predetermined requirement defined by the PCAs content of the lube oil fraction. Alternatively, the extract is cooled to further separate into the extract and the raffinate, and the second raffinate is used for the rubber process oil.Type: GrantFiled: January 21, 1999Date of Patent: June 19, 2001Assignee: Japan Energy CorporationInventors: Takashi Kaimai, Kazumitsu Fujihara, Yoshiyuki Morishima
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Patent number: 5232924Abstract: A heterocyclic compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group, an aryl group which may be substituted with one or more substituents selected from the group consisting of a halogen atom, an alkoxy group, an alkyl group and a trihalogenomethyl group; .lambda. represents 0 or 1; ring A represents a 6 membered heterocyclic ring containing the nitrogen atom shared with the triazine ring and which may contain one or more double bonds; Y represents a substituted or unsubstituted alkylene group having 1 to 15 carbon atoms; and Q represents a group represented by formula (II): ##STR2## wherein R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are represented by substituents disclosed herein; or salt thereof, and intermediates therefor are described.The compound of formula (I) or salt thereof exhibit selective serotonin 2-receptor antagonistic activity and are useful for the prevention or treatment of circulatory diseases, e.g.Type: GrantFiled: June 5, 1990Date of Patent: August 3, 1993Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Yoshifumi Watanabe, Hiroyuki Usui, Toshiro Shibano, Tsuyoshi Tanaka, Yoshiyuki Morishima, Megumi Yasuoka