Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Abstract: A control apparatus for work machines includes a position designation reception unit configured to identify designation of a position with respect to a state image displayed on a display panel and a screen control unit configured to perform screen control according to an image displayed at the position that has been identified, among partial images constituting parts of the state image.

Abstract: In a construction method using an excavator that is controlled by manual operation, and an excavator that includes an automatic working-equipment control unit automatically controlling second working equipment on the basis of at least one of a current terrain and a designed terrain of a construction range in a construction site, and a tooth-edge position of the second working equipment, a progress rate that indicates a volume of soil having been excavated by the excavator to a target volume of soil to be excavated by the excavator in the construction range is calculated, and when the progress rate is equal to or larger than a threshold, the excavator stops construction of the construction range, and the excavator takes over the construction of the construction range, from the excavator.

Abstract: The work state identifying unit identifies a work state of a work machine disposed in a construction site at each time point and a work state of a transport vehicle traveling at the construction site at each time point. The time chart generation unit that generates a time chart representing the work state of the work machine at each time point and a time chart representing the work state of the transport vehicle at each time point on the basis of the identified work states. The output control unit that outputs the time charts on an identical screen with a time axis as a common axis.

Abstract: A control apparatus for work machines includes a position designation reception unit configured to identify designation of a position with respect to a state image displayed on a display panel and a screen control unit configured to perform screen control according to an image displayed at the position that has been identified, among partial images constituting parts of the state image.

Abstract: A reproduction device includes an acquisition unit, a reception unit, and a reproduction unit. The acquisition unit acquires log information including angle information of a movable part of a work machine. The log information is associated with time. The reception unit receives a reproduction instruction usable to reproduce a movement of the work machine. The reproduction unit reproduces the movement of the work machine by sequentially applying the angle information to a work machine model upon receiving the reproduction instruction.

Abstract: A topographic information transmission device which is provided in a construction site includes an image data reception unit that receives a plurality of pieces of image data in which a landform of the construction site is captured, a three-dimensional data creation unit that creates three-dimensional data of the construction site on the basis of the plurality of pieces of image data, an amount-reduction processing unit that performs an amount reduction process of reducing a total data amount of the created three-dimensional data, and a topographic information transmission unit that transmits amount-reduced three-dimensional data having undergone the amount reduction process to an information providing device.

Abstract: The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).

Abstract: A work state identifying unit identifies work states of a work machine. A parameter identifying unit identifies a parameter related to a work amount per unit time of the work machine or a parameter related to a speed of the work machine for each of the identified work states on the basis of a time series of position data, azimuth data, or speed data of the work machine.

Abstract: A reproduction device includes an acquisition unit, a reception unit, a reproduction unit, and an estimation unit. The acquisition unit acquires log information of a work machine, which is associated with time. The reception unit receives a reproduction instruction for an operation of the work machine. The reproduction unit reproduces the operation of the work machine, by sequentially applying angle information of the work machine that is included in the log information, to a work machine model in a case of receiving the reproduction instruction. The estimation unit estimates a work content of the work machine at each time, based on the log information.

Abstract: An entry direction determination unit determines whether or not an entry direction of a vehicle into an output determination region is a predetermined direction in a case where the vehicle is located in a predetermined region or at a predetermined point. An output unit determines whether or not predetermined information is to be output on the basis of whether or not the entry direction is the predetermined direction.

Abstract: An operation information transmission device transmits a state of each work medium performing work in a construction site (F) to an information providing device. The operation information transmission device includes an image data acquisition unit that acquires image data including the work medium, a type/state specifying unit that specifies the type and a state of the work medium included in the image data, and an operation information transmission unit that transmits operation information indicating the specified type and state of the work medium to the information providing device.

Abstract: The present invention establishes a method for treating cardiac dysfunction. An oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to a part of the intron 55 region of a dystrophin gene, which comprises the sequence of 5?-TGTCTTCCT-3? or 5?-CAGCTTGAACCGGGC-3? (SEQ ID NO: 64) (wherein “T” may be “U” in either sequence), a pharmacologically acceptable salt thereof, or a solvate thereof. A prophylactic and/or a therapeutic for cardiac dysfunction, comprising the above-described oligonucleotide, a pharmacologically acceptable salt thereof, or a solvate thereof. A suppressor of Dp116 expression, comprising the above-described oligonucleotide, a pharmacologically acceptable salt thereof, or a solvate thereof.

Abstract: An operation information transmission device transmits a state of each work medium performing work in a construction site (F) to an information providing device. The operation information transmission device includes an image data acquisition unit that acquires image data including the work medium, a type/state specifying unit that specifies the type and a state of the work medium included in the image data, and an operation information transmission unit that transmits operation information indicating the specified type and state of the work medium to the information providing device.

Abstract: A topographic information transmission device which is provided in a construction site includes an image data reception unit that receives a plurality of pieces of image data in which a landform of the construction site is captured, a three-dimensional data creation unit that creates three-dimensional data of the construction site on the basis of the plurality of pieces of image data, an amount-reduction processing unit that performs an amount reduction process of reducing a total data amount of the created three-dimensional data, and a topographic information transmission unit that transmits amount-reduced three-dimensional data having undergone the amount reduction process to an information providing device.

Abstract: A position/pose acquisition unit acquires a position and a pose of a viewpoint in a real space. A site data disposition unit disposes site data which is three-dimensional data representing a shape of a construction site in a virtual space on the basis of the position and the pose of the viewpoint. A machine data disposition unit disposes machine data which is three-dimensional data representing a shape of a work machine at a position corresponding to the site data in the virtual space. A rendering unit renders the disposed machine data.

Abstract: A construction site management device generates a dynamic state image which includes a map including a construction site, a vehicle mark representing a portion corresponding to a location where a vehicle disposed in the construction site on the map is located, identification information of the vehicle indicated by the vehicle mark, and a standstill mark representing a portion corresponding to a location where the vehicle is at a standstill, and which represents a dynamic state of the vehicle in a predetermined period.

Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to the cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648G>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Abstract: An entry direction determination unit determines whether or not an entry direction of a vehicle into an output determination region is a predetermined direction in a case where the vehicle is located in a predetermined region or at a predetermined point. An output unit determines whether or not predetermined information is to be output on the basis of whether or not the entry direction is the predetermined direction.

Abstract: The work state identifying unit identifies a work state of a work machine disposed in a construction site at each time point and a work state of a transport vehicle traveling at the construction site at each time point. The time chart generation unit that generates a time chart representing the work state of the work machine at each time point and a time chart representing the work state of the transport vehicle at each time point on the basis of the identified work states. The output control unit that outputs the time charts on an identical screen with a time axis as a common axis.