Patents by Inventor Yoshiyuki Saruwatari
Yoshiyuki Saruwatari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11608447Abstract: Disclosed are a cell culture substrate that can be modified from its cell-inadhesibleness to make it cell-adhesible, by a convenient and low-cost treatment, and particularly, a substrate that allows position-specific culture of one or more kinds of cells. The substrate has on its surface a layer made of a photomodifiable polymer that comprises a monomer, as component (A), represented by Formula (1): wherein R1 denotes hydrogen or a methyl group, and R2 denotes an alkyl group having 1-22 carbon atoms, respectively, and n denotes an integer of 1-30, and a component (B) having a trialkoxysilyl group, which forms a layer.Type: GrantFiled: November 9, 2017Date of Patent: March 21, 2023Assignees: THE UNIVERSITY OF TOYAMA, OSAKA ORGANIC CHEMICAL INDUSTRY CO., LTD.Inventors: Hiromi Kitano, Tadashi Nakaji, Yoshiyuki Saruwatari, Kazuyoshi Matsuoka
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Patent number: 11530286Abstract: The present invention provides a protein aggregation inhibitor for use in preventing aggregation of a protein, containing a crosslinked polymer obtained by polymerizing polymerizable polymer components containing a sulfobetaine polymer obtained by polymerizing monomer components containing a sulfobetaine monomer, the sulfobetaine monomer, and a crosslinkable monomer.Type: GrantFiled: May 30, 2017Date of Patent: December 20, 2022Assignees: OSAKA ORGANIC CHEMICAL INDUSTRY LTD., JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kazuaki Matsumura, Rajan Robin, Yoko Taniyama, Yoshiyuki Saruwatari
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Patent number: 10995160Abstract: The present invention provides a protein aggregation inhibitor for use in preventing aggregation of a protein, which contains a terminal sulfanyl group-containing sulfobetaine polymer having a repeat unit derived from a sulfobetaine monomer represented by the formula (II), and a noble metal particle, and in which the terminal sulfanyl group-containing sulfobetaine polymer is chemisorbed on the noble metal particle by the sulfanyl group (the groups in the following formula are as defined in the DESCRIPTION).Type: GrantFiled: June 29, 2017Date of Patent: May 4, 2021Assignees: OSAKA ORGANIC CHEMICAL INDUSTRY LTD., JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kazuaki Matsumura, Rajan Robin, Yoko Taniyama, Yoshiyuki Saruwatari
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Publication number: 20200332044Abstract: The present invention provides a protein aggregation inhibitor for use in preventing aggregation of a protein, containing a crosslinked polymer obtained by polymerizing polymerizable polymer components containing a sulfobetaine polymer obtained by polymerizing monomer components containing a sulfobetaine monomer, the sulfobetaine monomer, and a crosslinkable monomer.Type: ApplicationFiled: May 30, 2017Publication date: October 22, 2020Applicants: OSAKA ORGANIC CHEMICAL INDUSTRY LTD., JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kazuaki MATSUMURA, Rajan ROBIN, Yoko TANIYAMA, Yoshiyuki SARUWATARI
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Publication number: 20190322784Abstract: Disclosed are a cell culture substrate that can be modified from its cell-inadhesibleness to make it cell-adhesible, by a convenient and low-cost treatment, and particularly, a substrate that allows position-specific culture of one or more kinds of cells. The substrate has on its surface a layer made of a photomodifiable polymer that comprises a monomer, as component (A), represented by Formula (1): wherein R1 denotes hydrogen or a methyl group, and R2 denotes an alkyl group having 1-22 carbon atoms, respectively, and n denotes an integer of 1-30, and a component (B) having a trialkoxysilyl group, which forms a layer.Type: ApplicationFiled: November 9, 2017Publication date: October 24, 2019Inventors: Hiromi KITANO, Tadashi NAKAJI, Yoshiyuki SARUWATARI, Kazuyoshi MATSUOKA
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Publication number: 20190161563Abstract: The present invention provides a protein aggregation inhibitor for use in preventing aggregation of a protein, which contains a terminal sulfanyl group-containing sulfobetaine polymer having a repeat unit derived from a sulfobetaine monomer represented by the formula (II), and a noble metal particle, and in which the terminal sulfanyl group-containing sulfobetaine polymer is chemisorbed on the noble metal particle by the sulfanyl group (the groups in the following formula are as defined in the DESCRIPTION).Type: ApplicationFiled: June 29, 2017Publication date: May 30, 2019Applicants: OSAKA ORGANIC CHEMICAL INDUSTRY LTD., JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kazuaki MATSUMURA, Rajan ROBIN, Yoko TANIYAMA, Yoshiyuki SARUWATARI
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Publication number: 20180305573Abstract: Provided are a clear coating composition which is used for top coats, the composition containing a crosslinking agent and a functional group-containing (meth)acrylate polymer formed by polymerization of a monomer component that includes an aromatic ring-containing (meth)acrylate and a functional group-containing monomer. Also provided is a clear coat composition which is used for top coats, the composition containing a crosslinking agent and a functional group-containing (meth)acrylate polymer formed by polymerization of a monomer component that includes a functional group-containing monomer and a fluorine atom-containing monomer. This clear coat composition has low colorability, has a high refractive index without the use of a filler, provides excellent glossy even when a filler is used, and can be applied to a thick film.Type: ApplicationFiled: June 29, 2018Publication date: October 25, 2018Applicants: OSAKA ORGANIC CHEMICAL INDUSTRY LTD., HONDA MOTOR CO., LTD.Inventors: Mitsuko Kitanohara, Kazuyoshi Matsuoka, Yoshiyuki Saruwatari, Keisuke Kojima, Masuo Kondo
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Patent number: 10040965Abstract: Provided are a clear coating composition which is used for top coats, the composition containing a crosslinking agent and a functional group-containing (meth)acrylate polymer formed by polymerization of a monomer component that includes an aromatic ring-containing (meth)acrylate and a functional group-containing monomer. Also provided is a clear coat composition which is used for top coats, the composition containing a crosslinking agent and a functional group-containing (meth)acrylate polymer formed by polymerization of a monomer component that includes a functional group-containing monomer and a fluorine atom-containing monomer. This clear coat composition has low colorability, has a high refractive index without the use of a filler, provides excellent glossy even when a filler is used, and can be applied to a thick film.Type: GrantFiled: November 19, 2014Date of Patent: August 7, 2018Assignees: OSAKA ORGANIC CHEMICAL INDUSTRY LTD., HONDA MOTOR CO., LTD.Inventors: Mitsuko Kitanohara, Kazuyoshi Matsuoka, Yoshiyuki Saruwatari, Keisuke Kojima, Masuo Kondo
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Patent number: 9976000Abstract: An aqueous gel that is prepared by gelling a polymer components, the polymer components containing polymer A, which is obtained by polymerizing a monomer component containing a betaine monomer represented by the formula (I): wherein R1 represents hydrogen atom or an alkyl group, R2 represents an alkylene, arylene, aralkylene, —COOH— or —CONH— group; R3 and R4 represent an alkyl group, and R5 represents an alkylene group, and a polymer B, which is obtained by polymerizing a monomer component containing an acidic monomer represented by the formula (II): wherein R1 represents hydrogen atom or an alkyl group; R6 represents an optionally neutralized sulfonate group, an optionally neutralized phosphate group, or an alkyl, aryl, aralkyl, carboxyl or amino group carrying an optionally neutralized sulfonate group or an optionally neutralized phosphate group.Type: GrantFiled: November 7, 2014Date of Patent: May 22, 2018Assignees: NATIONAL UNIVERSITY CORP. HOKKAIDO UNIVERSITY, OSAKA ORGANIC CHEMICAL INDUSTRIES LTD.Inventors: Jian Ping Gong, Takayuki Kurokawa, Haiyan Yin, Taigo Akasaki, Yoshiyuki Saruwatari
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Publication number: 20180118859Abstract: Provided is a protein aggregation inhibitor capable of inhibiting aggregation of a protein even when the protein is heated, and further, capable of inhibiting a decrease in the protein activity even when the protein is heated, which characteristically contains a sulfobetaine polymer obtained by polymerizing monomer components containing sulfobetaine monomer represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group, R2 is an alkylene group having a carbon number of 1-4, R3 is an alkyl group having a carbon number of 1-4, R4 is an alkylene group having a carbon number of 1-4, and X is an —NH— group or an —O— group.Type: ApplicationFiled: May 10, 2016Publication date: May 3, 2018Applicants: OSAKA ORGANIC CHEMICAL INDUSTRY LTD., JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kazuaki MATSUMURA, Rajan ROBIN, Tsuyoshi FURUKAWA, Kentaro MAEHARA, Yoshiyuki SARUWATARI
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Publication number: 20160297984Abstract: Provided are a clear coating composition which is used for top coats, the composition containing a crosslinking agent and a functional group-containing (meth)acrylate polymer formed by polymerization of a monomer component that includes an aromatic ring-containing (meth)acrylate and a functional group-containing monomer. Also provided is a clear coat composition which is used for top coats, the composition containing a crosslinking agent and a functional group-containing (meth)acrylate polymer formed by polymerization of a monomer component that includes a functional group-containing monomer and a fluorine atom-containing monomer. This clear coat composition has low colorability, has a high refractive index without the use of a filler, provides excellent glossy even when a filler is used, and can be applied to a thick film.Type: ApplicationFiled: November 19, 2014Publication date: October 13, 2016Applicants: OSAKA ORGANIC CHEMICAL INDUSTRY LTD., HONDA MOTOR CO., LTD.Inventors: Mitsuko Kitanohara, Kazuyoshi Matsuoka, Yoshiyuki Saruwatari, Keisuke Kojima, Masuo Kondo
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Patent number: 9434858Abstract: A hydrophilic coating agent for use in the formation of a coating film that can keep hydrophilicity, an anti-fogging property and an anti-fogging effect thereof and has water resistance, the coating agent including an alkoxysilyl-group-containing compound, a film which has an anti-fogging property and can be produced by shaping the hydrophilic coating agent into a film-like form; and a product which has an anti-fogging layer formed on the surface thereof, wherein the anti-fogging layer is formed from the hydrophilic coating agent.Type: GrantFiled: May 28, 2015Date of Patent: September 6, 2016Assignee: OSAKA ORGANIC CHEMICAL INDUSTRY LTD.Inventors: Kazuyoshi Matsuoka, Yoshiyuki Saruwatari, Masayuki Ando
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Patent number: 9434927Abstract: A method for manufacturing a cell culture substrate obtained by forming a coating layer of a polymer on the surface of a substrate, wherein the polymer is formed by polymerizing a monomer component containing a nitrogen atom-containing monomer represented by formula (I): wherein R1 is hydrogen atom or methyl group, R2 is an alkylene group having 1 to 6 carbon atoms, each of R3 and R4 is independently an alkyl group having 1 to 4 carbon atoms, R5 is an alkylene group having 1 to 4 carbon atoms, and Y is oxygen atom or —NH— group, includes irradiating the polymer with ion beam at a predetermined position of the coating layer of the polymer, to remove the coating layer of the polymer irradiated with the ion beam.Type: GrantFiled: August 30, 2011Date of Patent: September 6, 2016Assignee: OSAKA ORGANIC CHEMICAL INDUSTRY LTD.Inventors: Hiromi Kitano, Yoshiyuki Saruwatari, Kazuyoshi Matsuoka
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Publication number: 20150259570Abstract: A hydrophilic coating agent for use in the formation of a coating film that can keep hydrophilicity, an anti-fogging property and an anti-fogging effect thereof and has water resistance, the coating agent including an alkoxysilyl-group-containing compound, a film which has an anti-fogging property and can be produced by shaping the hydrophilic coating agent into a film-like form; and a product which has an anti-fogging layer formed on the surface thereof, wherein the anti-fogging layer is formed from the hydrophilic coating agent.Type: ApplicationFiled: May 28, 2015Publication date: September 17, 2015Applicant: OSAKA ORGANIC CHEMICAL INDUSTRY LTD.Inventors: Kazuyoshi Matsuoka, Yoshiyuki Saruwatari, Masayuki Ando
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Publication number: 20150133566Abstract: An aqueous gel that is prepared by gelling a polymer components, the polymer components containing polymer A, which is obtained by polymerizing a monomer component containing a betaine monomer represented by the formula (I): wherein R1 represents hydrogen atom or an alkyl group, R2 represents an alkylene, arylene, aralkylene, —COOH- or —CONH-group; R3 and R4 represent an alkyl group, and R5 represents an alkylene group, and a polymer B, which is obtained by polymerizing a monomer component containing an acidic monomer represented by the formula (II): wherein R1 represents hydrogen atom or an alkyl group; R6 represents an optionally neutralized sulfonate group, an optionally neutralized phosphate group, or an alkyl, aryl, aralkyl, carboxyl or amino group carrying an optionally neutralized sulfonate group or an optionally neutralized phosphate group.Type: ApplicationFiled: November 7, 2014Publication date: May 14, 2015Inventors: Jian Ping Gong, Takayuki Kurokawa, Haiyan Yin, Taigo Akasaki, Yoshiyuki Saruwatari
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Publication number: 20130224861Abstract: A method for manufacturing a cell culture substrate obtained by forming a coating layer of a polymer on the surface of a substrate, wherein the polymer is formed by polymerizing a monomer component containing a nitrogen atom-containing monomer represented by formula (I): wherein R1 is hydrogen atom or methyl group, R2 is an alkylene group having 1 to 6 carbon atoms, each of R3 and R4 is independently an alkyl group having 1 to 4 carbon atoms, R5 is an alkylene group having 1 to 4 carbon atoms, and Y is oxygen atom or —NH— group, includes irradiating the polymer with ion beam at a predetermined position of the coating layer of the polymer, to remove the coating layer of the polymer irradiated with the ion beam.Type: ApplicationFiled: August 30, 2011Publication date: August 29, 2013Applicant: OSAKA ORGANIC CHEMICAL INDUSTRY LTD.Inventors: Hiromi Kitano, Yoshiyuki Saruwatari, Kazuyoshi Matsuoka
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Patent number: 7662898Abstract: A biocompatible material having excellent biocompatibility such as small interaction with a component of a living body such as a protein or blood cell. A biocompatible material comprising a polymer obtained by polymerizing a monomer composition comprising an amino acid-type betaine monomer represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group; R2 is an alkylene group having 1 to 6 carbon atoms; each of R3 and R4 is independently an alkyl group having 1 to 4 carbon atoms; R5 is an alkylene group having 1 to 4 carbon atoms; and Z is an oxygen atom or an —NH group; and a polymerizable monomer represented by the formula (II): wherein R1 is as defined above; and R6 is a monovalent organic group, in a weight ratio, i.e. amino acid-type betaine monomer/polymerizable monomer, of from 1/99 to 100/1. The biocompatible material can be suitably used, for example, in food, a food additive, a medicament, a quasi-drug, a medical device, cosmetics, a toiletry article, or the like.Type: GrantFiled: May 18, 2005Date of Patent: February 16, 2010Assignee: Osaka Organic Chemical Ind., Ltd.Inventors: Hiromi Kitano, Makoto Genmei, Yoshiyuki Saruwatari, Takahiro Mukaiyama
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Publication number: 20080262181Abstract: A biocompatible material having excellent biocompatibility such as small interaction with a component of a living body such as a protein or blood cell. A biocompatible material comprising a polymer obtained by polymerizing a monomer composition comprising an amino acid-type betaine monomer represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group; R2 is an alkylene group having 1 to 6 carbon atoms; each of R3 and R4 is independently an alkyl group having 1 to 4 carbon atoms; R5 is an alkylene group having 1 to 4 carbon atoms; and Z is an oxygen atom or an —NH group; and a polymerizable monomer represented by the formula (II): wherein R1 is as defined above; and R6 is a monovalent organic group, in a weight ratio, i.e. amino acid-type betaine monomer/polymerizable monomer, of from 1/99 to 100/1. The biocompatible material can be suitably used, for example, in food, a food additive, a medicament, a quasi-drug, a medical device, cosmetics, a toiletry article, or the like.Type: ApplicationFiled: May 18, 2005Publication date: October 23, 2008Applicant: OSKA ORGANIC CMEICAL IND., LTD.Inventors: Hiromi Kitano, Makoto Genmei, Yoshiyuki Saruwatari, Takahiro Mukaiyama