Abstract: An activator suitable for immune response in tumor immunotherapy using an immune checkpoint inhibitor. An agent suitable for potentiating an antitumor effect of an immune checkpoint inhibitor, may contain a probiotic and a prebiotic as active ingredients.

Abstract: An inverter device applies an excitation current to an excitation winding of a step-up transformer through a switching element, and outputs an output voltage with an alternating-current half-wave waveform from an output winding of the step-up transformer. The inverter device includes: an input-voltage detecting unit that detects a state of the input voltage, as a voltage; a current detecting unit that converts a current flowing through the switching element into a voltage to detects the current; and a comparing unit that compares a detected current value detected by the current detecting unit with a detected input voltage value detected by the input-voltage detecting unit, and detects a high-current period in which the detected current value exceeds the detected input voltage value. Based on information indicating the high-current period detected by the comparing unit, the control circuit adjusts a period in which the switching element is turned on.

Abstract: An inverter device applies an excitation current to an excitation winding of a step-up transformer through a switching element, and outputs an output voltage with an alternating-current half-wave waveform from an output winding of the step-up transformer. The inverter device includes: an input-voltage detecting unit that detects a state of the input voltage, as a voltage; a current detecting unit that converts a current flowing through the switching element into a voltage to detects the current; and a comparing unit that compares a detected current value detected by the current detecting unit with a detected input voltage value detected by the input-voltage detecting unit, and detects a high-current period in which the detected current value exceeds the detected input voltage value. Based on information indicating the high-current period detected by the comparing unit, the control circuit adjusts a period in which the switching element is turned on.

Abstract: An image-forming apparatus includes a head unit configured to include line-type recording heads for ejecting ink droplets, a transport mechanism disposed facing the recording head and configured to transport a sheet, a maintain-recovery mechanism disposed downstream from the transport mechanism in a direction in which the sheet is transported and configured to maintain and recover the line type recording heads, and a head drive mechanism configured to move the head unit between a position facing the transport mechanism and a position facing the maintain-recovery mechanism in the direction in which the sheet is transported.

Abstract: An image-forming apparatus includes a head unit configured to include line-type recording heads for ejecting ink droplets, a transport mechanism disposed facing the recording head and configured to transport a sheet, a maintain-recovery mechanism disposed downstream from the transport mechanism in a direction in which the sheet is transported and configured to maintain and recover the line type recording heads, and a head drive mechanism configured to move the head unit between a position facing the transport mechanism and a position facing the maintain-recovery mechanism in the direction in which the sheet is transported.

Abstract: A stencil printer of the present invention perforates, or cuts, a thermosensitive stencil with a thermal head to thereby make a master. The stencil printer includes a stencil distinguishing device for automatically identifying the kind of the stencil or a master setting device for allowing the operator of the printer to set the kind of the stencil. An adjusting device selects, among master making conditions experimentally determined beforehand, a master making condition matching with information output from the stencil distinguishing device or the stencil setting device. The operator can easily change the master making condition in accordance with the kind of a stencil to use.

Abstract: A stencil printer of the present invention perforates, or cuts, a thermosensitive stencil with a thermal head to thereby make a master. The stencil printer includes a stencil distinguishing device for automatically identifying the kind of the stencil or a master setting device for allowing the operator of the printer to set the kind of the stencil. An adjusting device selects, among master making conditions experimentally determined beforehand, a master making condition matching with information output from the stencil distinguishing device or the stencil setting device. The operator can easily change the master making condition in accordance with the kind of a stencil to use.

Abstract: A thermal master making device and a thermal printer including the same are disclosed. A thermistor senses ambient temperature around a thermal head. A correcting device corrects the amount of heat to be generated by the thermal head, i.e., the duration of energization at least two times during a single master making operation. This configuration reduces a change in the perforation conditions of a thermosensitive medium ascribable to the heat accumulation characteristic of the head. The printer achieves high resolution, high-speed master making and space saving.

Abstract: A stencil printer of the present invention perforates, or cuts, a thermosensitive stencil with a thermal head to thereby make a master. The stencil printer includes a stencil distinguishing device for automatically identifying the kind of the stencil or a master setting device for allowing the operator of the printer to set the kind of the stencil. An adjusting device selects, among master making conditions experimentally determined beforehand, a master making condition matching with information output from the stencil distinguishing device or the stencil setting device. The operator can easily change the master making condition in accordance with the kind of a stencil to use.

Abstract: A thermal master making device and a thermal printer including the same are disclosed. A thermistor senses ambient temperature around a thermal head. A correcting device corrects the amount of heat to be generated by the thermal head, i.e., the duration of energization at least two times during a single master making operation. This configuration reduces a change in the perforation conditions of a thermosensitive medium ascribable to the heat accumulation characteristic of the head. The printer achieves high resolution, high-speed master making and space saving.

Abstract: A master making device includes a thermal head with heat generating elements and a platen roller. While the head and platen roller convey a thermosensitive medium in a subscanning direction perpendicular to a main scanning direction, the heat generating elements selectively generate heat in order to perforate the medium in accordance with an image signal. The head includes a stepped portion formed at a medium outlet side in the subscanning direction. The edges of the heat generating elements adjoining the medium outside side are located at a distance of 0.018 mm to 0.5 mm from the end of the stepped portion adjoining the above edges. It is not necessary to position the head with respect to an effective nip between it and the platen roller by a troublesome procedure. Further, the distance over which the perforated medium is conveyed is reduced to obviate the reduction or contraction of an image ascribable to the sticking of the medium to the head.

Abstract: New peptides represented by the following general formula (wherein X is OH or NH2, R is an amino acid residue selected from Arg, His, Lys, Methyl-Arg or Methyl-Tyr, n is an integer of 1-4, and in the case that n is 2-4, R may be identical with or different from each other) and an anti-dementia drug which contains one or more of these new peptides and has a high blood brain barrier (BBB) permeability and furthermore is low in a side effect.

Abstract: A stencil printer of the present invention perforates, or cuts, a thermosensitive stencil with a thermal head to thereby make a master. The stencil printer includes a stencil distinguishing device for automatically identifying the kind of the stencil or a master setting device for allowing the operator of the printer to set the kind of the stencil. An adjusting device selects, among master making conditions experimentally determined beforehand, a master making condition matching with information output from the stencil distinguishing device or the stencil setting device. The operator can easily change the master making condition in accordance with the kind of a stencil to use.

Abstract: A thermal master making device and a thermal printer including the same are disclosed. A thermistor senses ambient temperature around a thermal head. A correcting device corrects the amount of heat to be generated by the thermal head, i.e., the duration of energization at least two times during a single master making operation. This configuration reduces a change in the perforation conditions of a thermosensitive medium ascribable to the heat accumulation characteristic of the head. The printer achieves high resolution, high-speed master making and space saving.

Abstract: A thermal master making device includes a thermal head having a plurality of heating elements arranged in an array in the main scanning direction. The thermal head is caused to contact a stencil including a thermoplastic resin film. While the master is fed at a preselected feed pitch in the subscanning direction perpendicular to the main scanning direction, the heating elements selectively heat and perforate the film of the stencil in accordance with image data to thereby form an image in the stencil in the form of a dot pattern. A pitch at which the heating elements are arranged and the feed pitch are substantially equal to each other. The heating elements each have a length in the subscanning direction smaller than one-half of the feed pitch inclusive and have a length in the main scanning direction greater than the length in the subscanning direction. The device is capable of stably forming desired perforations in the stencil and extending the life of the heating element and therefore the life of the head.

Abstract: A thermal master making device and a thermal recording device each including a thermal head and a platen roller. The master making device thermally perforates, or cuts, a thermosensitive stencil for making a master while the recording device thermally records an image on a thermosensitive recording medium. The devices each reduce the corrosion of an expensive thermal head in any environmental conditions while guaranteeing the conveyance of the stencil or the recording medium. The stencil and recording medium each contain a corrosive substance in an antistatic agent or adhesive or an overcoat layer thereof. The corrosion of the head would directly translate into defective images. With the above devices, it is possible to reduce a burden on the user and to extend the life of the head. Extending the life of the head is desirable from the environmental standpoint also.

Abstract: A control device for a thermosensitive stencil printer capable of perforating a stencil in an optimal configuration matching a desired resolution in the subscanning direction and thereby producing desirable images. The device allows perforations to be formed in a stencil in an adequate size in the subscanning direction. Heating portions included in a thermal head are each sized, in the subscanning direction, smaller than a feed pitch corresponding to the highest resolution available with a resolution setting device.

Abstract: A control device for a thermosensitive stencil printer which is capable of perforating a stencil in an optimal configuration matching a desired resolution in the subscanning direction and thereby producing desirable images. The device allows perforations to be formed in a stencil in an adequate size in the subscanning direction. Heating portions included in a thermal head are each sized, in the subscanning direction, smaller than a feed pitch corresponding to the highest resolution available with a resolution setting device.

Abstract: A thrombolytic peptide composed of 136 amino acids residues, which has little problems of antigenicity and is efficacious in only small doses as compared with staphylokinase (SAK). This peptide is obtained by cleaving amino acids or peptides which do not affect the activity of SAK by using a trypsin protease. In particular, SAK-11, which is obtained by cleaving a peptide composed of ten amino acid residues at the N-terminal of SAK, is superior to SAK in the fibrinolysis, plasminogen activation, and fibrin specificity.