Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Abstract: The present invention relates to a 1- or 3-lead oral ECG device, shaped and implemented like a household digital thermometer. The 3-lead device comprises three contact electrodes: two contact electrodes on a body of the device, configured for contact with the left and right hands; and one contact electrode on a metallic tip of the device—which may comprise a thermometer—configured for contact with the mouth. The 1-lead device comprises any two of these three contact electrodes and a temperature sensor disposed in the metallic tip. A novel transformation of the three leads from the 3-lead device enables the ECG signals to be processed like a standard ECG that comprises a contact electrode in contact with the leg instead of the mouth. An oral ECG device of the invention may comprise other sensors, such as a pulse-oximetry sensor, respiratory rate sensor, skin temperature sensor, body impedance sensor, galvanic skin response sensor, and/or blood-flow sensor.

Abstract: An oral ECG device in the shape of a digital thermometer for recording an ECG and temperature of an individual comprises: a mouthpiece further comprising a temperature sensor; the mouthpiece insertable into an individual's mouth; a body further comprising a proximal electrode and a distal electrode for recording Lead-I of an ECG, the proximal and distal electrodes are holdable by left and right hands of the individual; each hand being in an electric contact with one of the proximal and distal electrodes; and a microcontroller preprogrammed for processing electric signals from the temperature sensor, proximal electrode and distal electrode. The proximal and distal electrodes are holdable by left and right hands in either orientation and the temperature sensor is positioned within individual's mouth in a contemporaneous manner.

Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Abstract: Embodiments include a displacement-generating battery cell for driving a drug-delivery device. The cell includes at least one volume-changing element. The cell also includes a housing formed according to a concertina-shaped design with folds in the walls thereof and containing an internal chemical reaction system. The arrangement of the chemical reaction system is such that as the cell is discharged, the volume-changing element expands, thereby lengthening the battery and thus reducing the extent of said folds, such that the cell becomes taller to reflect the expansion of the volume-changing component.

Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.

Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.

Abstract: A controllable drug delivery device for delivering a liquid injectable drug, the device comprising a drug reservoir (22), a drug administration device (28), a displacement-generating battery (20), and a current-depletion circuit (85), wherein displacement generated by the battery as current is depleted from the battery by the current depletion circuit displaces a wall of the drug reservoir thereby causing the reservoir to expel liquid injectable drug contained therein via the drug administration device, and wherein the drug delivery device further includes a controller (78) that is responsive to a measured parameter indicative of displacement generated by the battery for applying a variable load (80) across the battery in order to provide a substantially constant-current depletion of the battery and thereby cause the drug delivery device to deliver a substantially constant drug delivery rate.

Abstract: A controllable drug delivery device for delivering a liquid injectable drug, said device comprising a drug reservoir (22), a drug administration device (28), a displacement-generating battery (20), and a current-depletion circuit (85), wherein displacement generated by said battery as current is depleted from the battery by the current depletion circuit displaces a wall of the drug reservoir thereby causing the reservoir to expel liquid injectable drug contained therein via said drug administration device, and wherein the drug delivery device further includes a controller (78) that is responsive to a measured parameter indicative of displacement generated by the battery for applying a variable load (80) across the battery in order to provide a substantially constant-current depletion of said battery and thereby cause said drug delivery device to deliver a substantially constant drug delivery rate.

Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.