Abstract: The probe has a triple tube structure, in which an eluate from a liquid chromatograph flows through an innermost flow passage, a matrix solution flows through a flow passage outside the innermost flow passage, and the air or acetone flows through an outermost flow passage. Before analysis, acetone is flowed to rinse the matrix compound deposited in the previous analysis and clean the tip portion of the probe, and then the air is flowed to evaporate the rinsing solution.

Abstract: A tip portion of a probe has a triple tube structure in which a fused silica capillary on the innermost side, a capillary made of FEP outside the fused silica capillary, and a stainless pipe on the outermost side are disposed coaxially. An eluate from a liquid chromatograph flows through the innermost flow passage, a matrix solution flows through the flow passage between the fused silica capillary and the FEP capillary, and a rinsing solution or air flows through the flow passage between the FEP capillary and the pipe.

Abstract: A proximity sensor for measuring a distance between a probe and a sample plate is provided a sideway of the probe. The sample plate is mounted on a stage and moved vertically and horizontally. The stage is connected to a control unit for controlling the movement of the stage. The control unit makes a feedback control for the stage so that the measured value of the proximity sensor may be set to a preset value. When dropping a liquid droplet from the probe, the sample plate is moved upwards to shorten the distance between the probe and the sample plate and contact the liquid droplet with the sample plate, whereby the solution is fractionated.

Abstract: A distal end portion of a probe has a multi-pipe structure, in which an effluent solution from a high speed liquid chromatography passes through an innermost flow passage, a matrix solution through an outer flow passage, and the air through an outermost flow passage. A distal end of the outermost pipe extends 1.2 mm longer than the distal end of the inner duplex tube to form a liquid reservoir. When dropping a liquid droplet from the distal end of the probe, the air is blown out to expel the liquid gathered in the liquid reservoir to be dropped.

Abstract: In a preferred embodiment, a sample container storage part for storing a number of sample containers S, a nozzle for dropping a sample component separated and supplied by an LC and an additive liquid such as digestive fluid supplied from another liquid supplying part to the sample container S, a carrying mechanism for carrying and positioning the sample container at an arbitrary position under the nozzle, and a second nozzle, serving as a suction/injection mechanism, for sucking in the fractionated/collected sample component and injecting the sample component to another LC. The carrying mechanism provides a rotation mechanism. The carrying mechanism rotates over 180 degrees and carries the sample container S completed with fractionating/collecting to the position of the second nozzle, and the sample is sucked in by the second nozzle and injected to the LC of next stage.

Abstract: In a trap flow path, two diluents are supplied by solvent pumps that can respectively determine the flow rates independently. One of the diluents is allowed to pass through a fraction loop so as to direct a fractioned component(s) held in the fraction loop to a trap column together with a mobile phase. The other diluent is allowed to join with a flow path that has passed through the fraction loop on the downstream side of the fraction loop, and flows to the trap column while diluting the mobile phase from the flow path. In the trap column, the sample component(s) is condensed while being trapped therein.

Abstract: A sample solution is sent into a concentration column through a three-way joint and a three-way switching valve to trap and concentrate the sample components on the concentration column, followed by injecting the sample solution into an injector by operating a first dilution solvent pump. When a large volume of the sample solution is to be sent or when the sample solution has a high solvent strength, trapping and concentration on the concentration column may be facilitated by replacing the sample solvent with a second dilution solvent by allowing the second dilution solvent to flow into the three-way joint after setting the flow rate of the second dilution solvent from a second dilution solvent vessel to a prescribed flow rate using a second dilution solvent pump.

Abstract: An NMR device includes an NMR coil, and a sample flow path connected to a sample supply source and passing through the NMR coil. The NMR device can carry out an on-line measurement so that a portion passing through the NMR coil of the sample flow path functions as an NMR probe for measurement. A filler for absorbing a sample is provided at a position of the NMR probe in the sample flow path, and the NMR measurement is carried out in a state where the sample is absorbed by the filler. Thus, when the measurement is carried out, the sample is retained accurately at the NMR coil position while a very small quantity of sample is being concentrated.

Abstract: An NMR device includes an NMR coil, and a sample flow path connected to a sample supply source and passing through the NMR coil. The NMR device can carry out an on-line measurement so that a portion passing through the NMR coil of the sample flow path functions as an NMR probe for measurement. A filler for absorbing a sample is provided at a position of the NMR probe in the sample flow path, and the NMR measurement is carried out in a state where the sample is absorbed by the filler. Thus, when the measurement is carried out, the sample is retained accurately at the NMR coil position while a very small quantity of sample is being concentrated.

Abstract: A sample solution is sent into a concentration column through a three-way joint and a three-way switching valve to trap and concentrate the sample components on the concentration column, followed by injecting the sample solution into an injector by operating a first dilution solvent pump. When a large volume of the sample solution is to be sent or when the sample solution has a high solvent strength, trapping and concentration on the concentration column may be facilitated by replacing the sample solvent with a second dilution solvent by allowing the second dilution solvent to flow into the three-way joint after setting the flow rate of the second dilution solvent from a second dilution solvent vessel to a prescribed flow rate using a second dilution solvent pump.

Abstract: In order to irradiate a constant range of a separation passage of a microchip, light from a light source linearly extending along the separation passage is transmitted through a cylindrical lens and a bandpass filter and introduced into the separation passage. The light transmitted through the separation passage of the microchip is introduced into a photocell array through a cylindrical lens and detected. Measurement is repetitively performed and accumulated to determine migration patterns.