Abstract: Provided is a cell culture system capable of detecting a proliferative property of cells in a culture vessel at a desired timing during a culture when the cells are statically cultured in the culture vessel formed of a gas permeable member. A cell culture system is a system for statically culturing cells with a culture vessel at least partially formed of a gas permeable member. The cell culture system includes an oxygen concentration sensor that measures an oxygen concentration in a vicinity of a culture surface inside the culture vessel, and a proliferation detection unit that detects a proliferative property of the cells based on an oxygen permeability of the gas permeable member, a measurement value of the oxygen concentration sensor, an oxygen concentration around the culture vessel, and an oxygen consumption per cell of the cells.

Abstract: Provided is a contact lens that can exhibit excellent breaking elongation and surface hydrophilicity even when produced using a hydrophobic mold made of polypropylene or the like without performing a surface hydrophilic treatment. Further provided are a monomer composition and a polymer that can be suitably used for obtaining the contact lens. This monomer composition contains (A) a siloxanyl group-containing itaconic acid diester monomer, (B) an amide group-containing monomer, (C) a hydroxy group-containing monomer, (D) a siloxanyl group-containing (meth)acrylate, and (E) a cross-linking agent in a specific ratio.

Abstract: Provided is a monomer suitable for application to an ophthalmic device, the monomer showing high surface hydrophilicity, a high oxygen transmissibility, and appropriate mechanical strength when copolymerized with a polymerizable monomer, such as a hydrophilic monomer. It has been recognized that a phosphorylcholine group-containing polysiloxane monomer can solve the problems.

Abstract: Provided is a cell culture vessel for culturing cells with a high density having excellent gas permeability and strength. A bag-shaped cell culture vessel of a closed system includes at least one port and mutually opposed planar substrates. At least one of the planar substrates is formed of a gas permeable film, the at least one gas permeable film has an outer surface provided with a protruding portion having a shape different from an inner surface shape of the gas permeable film, a culture space for culturing cells is provided in the inner surface side of the gas permeable film, and when the gas permeable film is brought in contact with a planar surface, a space enabling ventilation is formed between the gas permeable film and the planar surface by the protruding portion.

Abstract: The phosphorylcholine group-containing polysiloxane monomer of the present invention is represented by the formula (1). In the formula, a represents an integer of 20 to 500, b represents an integer of 1 to 70, c represents an integer of 1 to 70, d represents 0 or 1, p and q each represent 0 or 1, X represents —CH2— or —CH2CH2—, and R represents an alkyl group having 2 to 18 carbon atoms. The present invention provides the phosphorylcholine group-containing polysiloxane monomer which gives, when copolymerized with a polymerizable monomer such as methacrylic acid or a hydrophilic monomer other than methacrylic acid, a polymer that exhibits surface hydrophilicity and sufficient stability as ophthalmic devices.

Abstract: Provided is a culture vessel for adherent cells that has a large culture portion surface area and ensures easily dissociating and recovering cells without consuming a medium or a dissociation solution more than necessary. The bag-shaped adherent cell culture vessel made of flexible packaging material includes a vessel body portion having a first vessel wall and a second vessel wall and one or more injecting/ejecting ports. The vessel body portion has an intermediate culture wall between the first vessel wall and the second vessel wall. A culture chamber is disposed in each of between the first vessel wall and the intermediate culture wall and between the second vessel wall and the intermediate culture wall, and a flow passage communicating between the respective culture chambers is disposed.

Abstract: A culture container made of a flexible packaging material where the culture container includes a first side surface portion and a second side surface portion that are mutually opposed. The culture container also includes at least an inner surface side of the first side surface portion which has a surface treatment such that, when a contact angle hysteresis is defined as an advance contact angle—a retreat contact angle at a time when water slips, a contact angle hysteresis of a surface on the inner surface side of the first side surface portion becomes larger than a contact angle hysteresis of a surface on an inner surface side of the second side surface portion. The culture container further includes a membrane made of a cell adhesion inhibitor that is formed on the inner surface side of the first side surface portion.

Abstract: Provided is a monomer composition for contact lenses, which uses a polysiloxane monomer to produce a polymer that shows satisfactory surface hydrophilicity and oxygen permeability, and that is excellent in modulus and elongation at break. It has been found that a monomer composition containing a phosphorylcholine group-containing polysiloxane monomer, a monovinyl ether monomer, and the like can achieve the above-mentioned object.

Abstract: An adherent cell culture substrate, which is a sheet-shaped substrate used for producing a culture vessel for adherent cells, includes a groove including a crest-shaped portion and a valley-shaped portion on one surface side of the substrate, in which a distance from a top end portion of the crest-shaped portion to the other surface of the substrate is 1 mm or less. Further, it is preferable that a cross section of the groove perpendicular to a direction in which the groove extends is formed in a substantially V-shape and an inclination angle of a side surface of the substantially V-shape of the groove is 80 degrees or less. Further, it is preferable that a plurality of the grooves are linearly arranged in parallel and the top end portions of the crest-shaped portions are formed in a linear shape.

Abstract: The invention is a phosphorylcholine group-containing vinyl monomer represented by the following formula (1): in the formula (1) R represents an alkylene group having 1 to 6 carbon atoms, and n represents an integer of 1 to 6. The invention provides a phosphorylcholine group-containing vinyl monomer useful as a raw material for a hydrogel having a lowered water content while maintaining surface hydrophilicity.

Abstract: Provided is a contact lens that can exhibit excellent breaking elongation and surface hydrophilicity even when produced using a hydrophobic mold made of polypropylene or the like without performing a surface hydrophilic treatment. Further provided are a monomer composition and a polymer that can be suitably used for obtaining the contact lens. This monomer composition contains (A) a siloxanyl group-containing itaconic acid diester monomer, (B) an amide group-containing monomer, (C) a hydroxy group-containing monomer, (D) a siloxanyl group-containing (meth)acrylate, and (E) a cross-linking agent in a specific ratio.

Abstract: In the production of a culture vessel in which a low cell-adhesive polymer as a coating agent is applied to a culture surface having a plurality of concave parts formed thereon, a use amount of the coating agent can be reduced. The low cell-adhesive polymer as the coating agent is applied to a surface of a culture base material in advance, and subsequently the culture base material is subjected to processing to form the culture vessel having the surface of the culture base material coated with the coating agent as the culture surface.

Abstract: Provided is a monomer suitable for application to an ophthalmic device, the monomer showing high surface hydrophilicity, a high oxygen transmissibility, and appropriate mechanical strength when copolymerized with a polymerizable monomer, such as a hydrophilic monomer. It has been recognized that a phosphorylcholine group-containing polysiloxane monomer can solve the problems.

Abstract: Provided is a culture container base material made of a polyolefin material, capable of readily forming a culture container for culturing adherent cells. The culture container base material is for culturing the adherent cells and made of the polyolefin material. At least a part of a surface of the base material is subjected to a surface treatment, where the surface of the base material is a culture surface of the culture container, and the surface subjected to the surface treatment has a static water contact angle of greater than 80° and a receding contact angle of less than 53°.

Abstract: Provided is a silicone contact lens having surface hydrophilicity and surface lubricity. It has been confirmed that a silicone contact lens including, on its surface, a graft polymer chain derived from a polyoxyethylene compound having a plurality of hydroxyl groups at a terminal thereof has surface hydrophilicity and surface lubricity.

Abstract: Provided is a silicone contact lens having surface hydrophilicity and surface lubricity. The silicone contact lens includes, on its surface, a graft polymer chain derived from a branched polyoxyethylene compound represented by the formula (1): where n represents from 3 to 1,150, a represents 0 or 2, and R1 represents a hydrogen atom or a methyl group.

Abstract: To provide a brake piping structure for saddled vehicle which can reduce the number of restraining members used for brake piping and allow brake piping to avoid interfering with other parts. The brake piping structure for saddled vehicles includes a pair of left and right rear frames connected to a rear portion of a vehicle body frame of a saddled vehicle and supporting a seat, a swing arm swingably supported, via a pivot, by the vehicle body frame, and brake piping which conveys hydraulic pressure generated by an ABS modulator to a rear brake caliper for a rear wheel. The ABS modulator is disposed between the pair of left and right rear frames. The brake piping extends from the ABS modulator forward and downward of the vehicle body along the rear frame and is, by being curved rearward of the vehicle body in front of the pivot and then by being routed under the swing arm, connected to the rear brake caliper.

Abstract: A culture container made of a flexible packaging material where the culture container includes a first side surface portion and a second side surface portion that are mutually opposed. The culture container also includes at least an inner surface side of the first side surface portion which has a surface treatment such that, when a contact angle hysteresis is defined as an advance contact angle—a retreat contact angle at a time when water slips, a contact angle hysteresis of a surface on the inner surface side of the first side surface portion becomes larger than a contact angle hysteresis of a surface on an inner surface side of the second side surface portion. The culture container further includes a membrane made of a cell adhesion inhibitor that is formed on the inner surface side of the first side surface portion.

Abstract: Provided is a silicone contact lens having surface hydrophilicity and surface lubricity. It has been confirmed that a silicone contact lens including, on its surface, a graft polymer chain derived from a polyoxyethylene compound having a plurality of hydroxyl groups at a terminal thereof has surface hydrophilicity and surface lubricity.

Abstract: Provided is a silicone contact lens having surface hydrophilicity and surface lubricity. The silicone contact lens includes, on its surface, a graft polymer chain derived from a branched polyoxyethylene compound represented by the formula (1): where n represents from 3 to 1,150, a represents 0 or 2, and R1 represents a hydrogen atom or a methyl group.